Int J Biol Sci 2024; 20(6):2151-2167. doi:10.7150/ijbs.92525 This issue Cite

Review

Advancements in technology for characterizing the tumor immune microenvironment

Honglin Yan, Xianli Ju, Aoling Huang, Jingping Yuan

Department of Pathology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China.

Citation:
Yan H, Ju X, Huang A, Yuan J. Advancements in technology for characterizing the tumor immune microenvironment. Int J Biol Sci 2024; 20(6):2151-2167. doi:10.7150/ijbs.92525. https://www.ijbs.com/v20p2151.htm
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Abstract

Graphic abstract

Immunotherapy plays a key role in cancer treatment, however, responses are limited to a small number of patients. The biological basis for the success of immunotherapy is the complex interaction between tumor cells and tumor immune microenvironment (TIME). Historically, research on tumor immune constitution was limited to the analysis of one or two markers, more novel technologies are needed to interpret the complex interactions between tumor cells and TIME. In recent years, major advances have already been made in depicting TIME at a considerably elevated degree of throughput, dimensionality and resolution, allowing dozens of markers to be labeled simultaneously, and analyzing the heterogeneity of tumour-immune infiltrates in detail at the single cell level, depicting the spatial landscape of the entire microenvironment, as well as applying artificial intelligence (AI) to interpret a large amount of complex data from TIME. In this review, we summarized emerging technologies that have made contributions to the field of TIME, and provided prospects for future research.

Keywords: Tumor immune microenvironment, Cytometry-based techniques, Multiplexing imaging techniques, RNA sequencing, Artificial intelligence


Citation styles

APA
Yan, H., Ju, X., Huang, A., Yuan, J. (2024). Advancements in technology for characterizing the tumor immune microenvironment. International Journal of Biological Sciences, 20(6), 2151-2167. https://doi.org/10.7150/ijbs.92525.

ACS
Yan, H.; Ju, X.; Huang, A.; Yuan, J. Advancements in technology for characterizing the tumor immune microenvironment. Int. J. Biol. Sci. 2024, 20 (6), 2151-2167. DOI: 10.7150/ijbs.92525.

NLM
Yan H, Ju X, Huang A, Yuan J. Advancements in technology for characterizing the tumor immune microenvironment. Int J Biol Sci 2024; 20(6):2151-2167. doi:10.7150/ijbs.92525. https://www.ijbs.com/v20p2151.htm

CSE
Yan H, Ju X, Huang A, Yuan J. 2024. Advancements in technology for characterizing the tumor immune microenvironment. Int J Biol Sci. 20(6):2151-2167.

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
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