Int J Biol Sci 2024; 20(7):2698-2726. doi:10.7150/ijbs.91832 This issue Cite

Review

LncRNAs as nodes for the cross-talk between autophagy and Wnt signaling in pancreatic cancer drug resistance

Yuhan Huang1, Rui Zhang1, Hao Lyu1, Shuai Xiao1, Dong Guo1, Xing-Zhen Chen2, Cefan Zhou1✉, Jingfeng Tang1✉

1. National "111" Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan, China, 430068.
2. Membrane Protein Disease Research Group, Department of Physiology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada, T6G2R3.

Citation:
Huang Y, Zhang R, Lyu H, Xiao S, Guo D, Chen XZ, Zhou C, Tang J. LncRNAs as nodes for the cross-talk between autophagy and Wnt signaling in pancreatic cancer drug resistance. Int J Biol Sci 2024; 20(7):2698-2726. doi:10.7150/ijbs.91832. https://www.ijbs.com/v20p2698.htm
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Abstract

Graphic abstract

Pancreatic cancer is a malignancy with high mortality. In addition to the few symptoms until the disease reaches an advanced stage, the high fatality rate is attributed to its rapid development, drug resistance and lack of appropriate treatment. In the selection and research of therapeutic drugs, gemcitabine is the first-line drug for pancreatic cancer. Solving the problem of gemcitabine resistance in pancreatic cancer will contribute to the progress of pancreatic cancer treatment. Long non coding RNAs (lncRNAs), which are RNA transcripts longer than 200 nucleotides, play vital roles in cellular physiological metabolic activities. Currently, our group and others have found that some lncRNAs are aberrantly expressed in pancreatic cancer cells, which can regulate the process of cancer through autophagy and Wnt/β-catenin pathways simultaneously and affect the sensitivity of cancer cells to therapeutic drugs. This review presents an overview of the recent evidence concerning the node of lncRNA for the cross-talk between autophagy and Wnt/β-catenin signaling in pancreatic cancer, together with the practicability of lncRNAs and the core regulatory factors as targets in therapeutic resistance.

Keywords: autophagy, drug resistance, lncRNA, pancreatic cancer, Wnt/β-catenin signaling


Citation styles

APA
Huang, Y., Zhang, R., Lyu, H., Xiao, S., Guo, D., Chen, X.Z., Zhou, C., Tang, J. (2024). LncRNAs as nodes for the cross-talk between autophagy and Wnt signaling in pancreatic cancer drug resistance. International Journal of Biological Sciences, 20(7), 2698-2726. https://doi.org/10.7150/ijbs.91832.

ACS
Huang, Y.; Zhang, R.; Lyu, H.; Xiao, S.; Guo, D.; Chen, X.Z.; Zhou, C.; Tang, J. LncRNAs as nodes for the cross-talk between autophagy and Wnt signaling in pancreatic cancer drug resistance. Int. J. Biol. Sci. 2024, 20 (7), 2698-2726. DOI: 10.7150/ijbs.91832.

NLM
Huang Y, Zhang R, Lyu H, Xiao S, Guo D, Chen XZ, Zhou C, Tang J. LncRNAs as nodes for the cross-talk between autophagy and Wnt signaling in pancreatic cancer drug resistance. Int J Biol Sci 2024; 20(7):2698-2726. doi:10.7150/ijbs.91832. https://www.ijbs.com/v20p2698.htm

CSE
Huang Y, Zhang R, Lyu H, Xiao S, Guo D, Chen XZ, Zhou C, Tang J. 2024. LncRNAs as nodes for the cross-talk between autophagy and Wnt signaling in pancreatic cancer drug resistance. Int J Biol Sci. 20(7):2698-2726.

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