Particulate matter facilitates amphiregulin-dependent lung cancer proliferation through glutamine metabolism

Jiang, Ya-Jing; Ho, Trung-Loc; Chao, Chia-Chia; He, Xiu-Yuan; Chen, Po-Chun; Cheng, Fang-Ju; Huang, Wei-Chien; Huang, Chang-Lun; Liu, Po-I; Tang, Chih-Hsin

doi:10.7150/ijbs.96210

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Int J Biol Sci 2024; 20(8):3126-3139. doi:10.7150/ijbs.96210 This issue Cite

Research Paper

Particulate matter facilitates amphiregulin-dependent lung cancer proliferation through glutamine metabolism

Ya-Jing Jiang¹, Trung-Loc Ho¹, Chia-Chia Chao², Xiu-Yuan He¹, Po-Chun Chen³, Fang-Ju Cheng^1,4, Wei-Chien Huang^1,4,5,6, Chang-Lun Huang⁷, Po-I Liu^8,9✉, Chih-Hsin Tang^{1,5,6,10,11✉}

1. Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.
2. Department of Respiratory Therapy, Fu-Jen Catholic University, New Taipei City, Taiwan.
3. Department of Life Science, National Taiwan Normal University, Taipei, Taiwan.
4. Center for Molecular Medicine, China Medical University Hospital, Taichung, Taiwan.
5. Department of Medical Research, China Medical University Hsinchu Hospital, Hsinchu, Taiwan.
6. Department of Medical Laboratory Science and Biotechnology, Asia University, Taichung, Taiwan.
7. Division of General Thoracic Surgery, Department of Surgery, Changhua Christian Hospital, Changhua, Taiwan.
8. Department of Physical Therapy, Asia University, Taichung, Taiwan.
9. Department of General Thoracic Surgery, Asia University Hospital, Taichung, Taiwan.
10. Department of Pharmacology, School of Medicine, China Medical University, Taichung, Taiwan.
11. Chinese Medicine Research Center, China Medical University, Taichung, Taiwan.

Citation:

Jiang YJ, Ho TL, Chao CC, He XY, Chen PC, Cheng FJ, Huang WC, Huang CL, Liu PI, Tang CH. Particulate matter facilitates amphiregulin-dependent lung cancer proliferation through glutamine metabolism. Int J Biol Sci 2024; 20(8):3126-3139. doi:10.7150/ijbs.96210. https://www.ijbs.com/v20p3126.htm

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Abstract

Although many cohort studies have reported that long-term exposure to particulate matter (PM) causes lung cancer, the molecular mechanisms underlying the PM-induced increases in lung cancer progression remain unclear. We applied the lung cancer cell line A549 (Parental; A549.Par) to PM for an extended period to establish a mimic PM-exposed lung cancer cell line, A549.PM. Our results indicate that A549.PM exhibits higher cell growth and proliferation abilities compared to A549.Par cells in vitro and in vivo. The RNA sequencing analysis found amphiregulin (AREG) plays a critical role in PM-induced cell proliferation. We observed that PM increases AREG-dependent lung cancer proliferation through glutamine metabolism. In addition, the EGFR/PI3K/AKT/mTOR signaling pathway is involved in PM-induced solute carrier family A1 member 5 (SLC1A5) expression and glutamine metabolism. Our findings offer important insights into how lung cancer proliferation develops upon exposure to PM.

Keywords: Lung cancer, Particulate matter, Glutamine metabolism, Amphiregulin, SLC1A5

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APA

Jiang, Y.J., Ho, T.L., Chao, C.C., He, X.Y., Chen, P.C., Cheng, F.J., Huang, W.C., Huang, C.L., Liu, P.I., Tang, C.H. (2024). Particulate matter facilitates amphiregulin-dependent lung cancer proliferation through glutamine metabolism. International Journal of Biological Sciences, 20(8), 3126-3139. https://doi.org/10.7150/ijbs.96210.

ACS

Jiang, Y.J.; Ho, T.L.; Chao, C.C.; He, X.Y.; Chen, P.C.; Cheng, F.J.; Huang, W.C.; Huang, C.L.; Liu, P.I.; Tang, C.H. Particulate matter facilitates amphiregulin-dependent lung cancer proliferation through glutamine metabolism. Int. J. Biol. Sci. 2024, 20 (8), 3126-3139. DOI: 10.7150/ijbs.96210.

NLM

CSE

Jiang YJ, Ho TL, Chao CC, He XY, Chen PC, Cheng FJ, Huang WC, Huang CL, Liu PI, Tang CH. 2024. Particulate matter facilitates amphiregulin-dependent lung cancer proliferation through glutamine metabolism. Int J Biol Sci. 20(8):3126-3139.

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