International Journal of Biological Sciences
ISSN: 1449-2288
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Int J Biol Sci 2024; 20(8):3219-3235. doi:10.7150/ijbs.96885 This issue Cite
Review
Unlocking the Nexus of Sirtuins: A Comprehensive Review of Their Role in Skeletal Muscle Metabolism, Development, and Disorders
Jiangxi Provincial Key Laboratory of Poultry Genetic Improvement, Institute of Biological Technology, Nanchang Normal University, Nanchang, 330032, China.
Citation:
Gibril BAA, Xiong X, Chai X, Xu Q, Gong J, Xu J. Unlocking the Nexus of Sirtuins: A Comprehensive Review of Their Role in Skeletal Muscle Metabolism, Development, and Disorders. Int J Biol Sci 2024; 20(8):3219-3235. doi:10.7150/ijbs.96885. https://www.ijbs.com/v20p3219.htm
Other stylesAbstract
The sirtuins constitute a group of histone deacetylases reliant on NAD+ for their activity that have gained recognition for their critical roles as regulators of numerous biological processes. These enzymes have various functions in skeletal muscle biology, including development, metabolism, and the body's response to disease. This comprehensive review seeks to clarify sirtuins' complex role in skeletal muscle metabolism, including glucose uptake, fatty acid oxidation, mitochondrial dynamics, autophagy regulation, and exercise adaptations. It also examines their critical roles in developing skeletal muscle, including myogenesis, the determination of muscle fiber type, regeneration, and hypertrophic responses. Moreover, it sheds light on the therapeutic potential of sirtuins by examining their impact on a range of skeletal muscle disorders. By integrating findings from various studies, this review outlines the context of sirtuin-mediated regulation in skeletal muscle, highlighting their importance and possible consequences for health and disease.
Keywords: sirtuins, skeletal muscle metabolism, development, disorders
Citation styles
APA
Gibril, B.A.A., Xiong, X., Chai, X., Xu, Q., Gong, J., Xu, J. (2024). Unlocking the Nexus of Sirtuins: A Comprehensive Review of Their Role in Skeletal Muscle Metabolism, Development, and Disorders. International Journal of Biological Sciences, 20(8), 3219-3235. https://doi.org/10.7150/ijbs.96885.
ACS
Gibril, B.A.A.; Xiong, X.; Chai, X.; Xu, Q.; Gong, J.; Xu, J. Unlocking the Nexus of Sirtuins: A Comprehensive Review of Their Role in Skeletal Muscle Metabolism, Development, and Disorders. Int. J. Biol. Sci. 2024, 20 (8), 3219-3235. DOI: 10.7150/ijbs.96885.
NLM
Gibril BAA, Xiong X, Chai X, Xu Q, Gong J, Xu J. Unlocking the Nexus of Sirtuins: A Comprehensive Review of Their Role in Skeletal Muscle Metabolism, Development, and Disorders. Int J Biol Sci 2024; 20(8):3219-3235. doi:10.7150/ijbs.96885. https://www.ijbs.com/v20p3219.htm
CSE
Gibril BAA, Xiong X, Chai X, Xu Q, Gong J, Xu J. 2024. Unlocking the Nexus of Sirtuins: A Comprehensive Review of Their Role in Skeletal Muscle Metabolism, Development, and Disorders. Int J Biol Sci. 20(8):3219-3235.
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