Int J Biol Sci 2024; 20(8):3236-3256. doi:10.7150/ijbs.93875 This issue Cite

Review

Polyphenols as Therapeutics in Respiratory Diseases: Moving from Preclinical Evidence to Potential Clinical Applications

Talha Bin Emran1,2,3✉*, Taslima Akter Eva4, Mehrukh Zehravi5✉*, Fahadul Islam3, Jishan Khan6, Shaik Kareemulla7, Uppuluri Varuna Naga Venkata Arjun8, Anitha Balakrishnan9, Poonam Popatrao Taru10, Firzan Nainu11, Emil Salim12, Safia Obaidur Rab13, Mohamed H. Nafady14, Polrat Wilairatana15, Moon Nyeo Park16, Bonglee Kim16✉

1. Department of Pathology and Laboratory Medicine, Warren Alpert Medical School, Brown University, Providence, RI 02912, USA.
2. Legorreta Cancer Center, Brown University, Providence, RI 02912, USA.
3. Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka 1207, Bangladesh.
4. Department of Pharmacy, Faculty of Biological Sciences, University of Chittagong, Chittagong 4331, Bangladesh.
5. Department of Clinical Pharmacy, College of Dentistry & Pharmacy, Buraydah Private Colleges, Buraydah 51418, Saudi Arabia.
6. Department of Pharmacy, International Islamic University Chittagong, Chittagong 4318, Bangladesh.
7. Department of Pharmacy Practice, M. M. College of Pharmacy (Maharishi Markandeshwar Deemed University), Mullana-Ambala, Haryana 133207, India.
8. Department of Pharmaceutics, School of Pharmaceutical Sciences, Vels Institute of Science, Technology, and Advanced Studies (VISTAS), Tamil Nadu, India.
9. Department of Pharmaceutics, GRT Institute of Pharmaceutical Education and Research, Tiruttani, India.
10. Department of Pharmacognosy, School of Pharmacy, Vishwakarma University, Kondhwa, Pune, India.
11. Department of Pharmacy, Faculty of Pharmacy, Hasanuddin University, Makassar 90245, Indonesia.
12. Department of Pharmacology and Clinical/Community Pharmacy, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, 20155, Indonesia.
13. Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia.
14. Faculty of Applied Health Science Technology, Misr University for Science and Technology, Giza 12568, Egypt.
15. Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand.
16. Department of Pathology, College of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul, 02453, Republic of Korea.
* These authors contributed equally.

Citation:
Emran TB, Eva TA, Zehravi M, Islam F, Khan J, Kareemulla S, Arjun UVNV, Balakrishnan A, Taru PP, Nainu F, Salim E, Rab SO, Nafady MH, Wilairatana P, Park MN, Kim B. Polyphenols as Therapeutics in Respiratory Diseases: Moving from Preclinical Evidence to Potential Clinical Applications. Int J Biol Sci 2024; 20(8):3236-3256. doi:10.7150/ijbs.93875. https://www.ijbs.com/v20p3236.htm
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Abstract

Graphic abstract

Respiratory diseases are the most common and severe health complication and a leading cause of death worldwide. Despite breakthroughs in diagnosis and treatment, few safe and effective therapeutics have been reported. Phytochemicals are gaining popularity due to their beneficial effects and low toxicity. Polyphenols are secondary metabolites with high molecular weights found at high levels in natural food sources such as fruits, vegetables, grains, and citrus seeds. Over recent decades, polyphenols and their beneficial effects on human health have been the subject of intense research, with notable successes in preventing major chronic non-communicable diseases. Many respiratory syndromes can be treated effectively with polyphenolic supplements, including acute lung damage, pulmonary fibrosis, asthma, pulmonary hypertension, and lung cancer. This review summarizes the role of polyphenols in respiratory conditions with sufficient experimental data, highlights polyphenols with beneficial effects for each, and identifies those with therapeutic potential and their underlying mechanisms. Moreover, clinical studies and future research opportunities in this area are discussed.

Keywords: Polyphenols, Respiratory diseases, Lung cancer, Asthma, ARDS, Tuberculosis


Citation styles

APA
Emran, T.B., Eva, T.A., Zehravi, M., Islam, F., Khan, J., Kareemulla, S., Arjun, U.V.N.V., Balakrishnan, A., Taru, P.P., Nainu, F., Salim, E., Rab, S.O., Nafady, M.H., Wilairatana, P., Park, M.N., Kim, B. (2024). Polyphenols as Therapeutics in Respiratory Diseases: Moving from Preclinical Evidence to Potential Clinical Applications. International Journal of Biological Sciences, 20(8), 3236-3256. https://doi.org/10.7150/ijbs.93875.

ACS
Emran, T.B.; Eva, T.A.; Zehravi, M.; Islam, F.; Khan, J.; Kareemulla, S.; Arjun, U.V.N.V.; Balakrishnan, A.; Taru, P.P.; Nainu, F.; Salim, E.; Rab, S.O.; Nafady, M.H.; Wilairatana, P.; Park, M.N.; Kim, B. Polyphenols as Therapeutics in Respiratory Diseases: Moving from Preclinical Evidence to Potential Clinical Applications. Int. J. Biol. Sci. 2024, 20 (8), 3236-3256. DOI: 10.7150/ijbs.93875.

NLM
Emran TB, Eva TA, Zehravi M, Islam F, Khan J, Kareemulla S, Arjun UVNV, Balakrishnan A, Taru PP, Nainu F, Salim E, Rab SO, Nafady MH, Wilairatana P, Park MN, Kim B. Polyphenols as Therapeutics in Respiratory Diseases: Moving from Preclinical Evidence to Potential Clinical Applications. Int J Biol Sci 2024; 20(8):3236-3256. doi:10.7150/ijbs.93875. https://www.ijbs.com/v20p3236.htm

CSE
Emran TB, Eva TA, Zehravi M, Islam F, Khan J, Kareemulla S, Arjun UVNV, Balakrishnan A, Taru PP, Nainu F, Salim E, Rab SO, Nafady MH, Wilairatana P, Park MN, Kim B. 2024. Polyphenols as Therapeutics in Respiratory Diseases: Moving from Preclinical Evidence to Potential Clinical Applications. Int J Biol Sci. 20(8):3236-3256.

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