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Volume 12 (4); 2016

Research Paper


Vitamin K2 Prevents Glucocorticoid-induced Osteonecrosis of the Femoral Head in Rats
Yue-Lei Zhang, Jun-Hui Yin, Hao Ding, Wei Zhang, Chang-Qing Zhang, You-Shui Gao
Int. J. Biol. Sci. 2016; 12(4): 347-358. doi:10.7150/ijbs.13269
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Lyophilized Powder of Catalpol and Puerarin Protects Neurovascular Unit from Stroke
Qiang XUE, Yang LIU, Ran HE, Sheng YANG, Jie TONG, Xu LI, Yi CHEN, Xiaoyu XU
Int. J. Biol. Sci. 2016; 12(4): 367-380. doi:10.7150/ijbs.14059
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Targeting Oncogenes into a Defined Subset of Mammary Cells Demonstrates That the Initiating Oncogenic Mutation Defines the Resulting Tumor Phenotype
Kimberly R. Holloway, Vidya C. Sinha, Wen Bu, Michael Toneff, Jie Dong, Yi Peng, Yi Li
Int. J. Biol. Sci. 2016; 12(4): 381-388. doi:10.7150/ijbs.12947
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Proton-sensing GPCR-YAP Signalling Promotes Cancer-associated Fibroblast Activation of Mesenchymal Stem Cells
Hongyi Zhu, Shangchun Guo, Yuelei Zhang, Junhui Yin, Wenjing Yin, Shicong Tao, Yang Wang, Changqing Zhang
Int. J. Biol. Sci. 2016; 12(4): 389-396. doi:10.7150/ijbs.13688
[Abstract] [Full text] [PDF] [PubMed] [PMC]


MiR-487a Promotes TGF-β1-induced EMT, the Migration and Invasion of Breast Cancer Cells by Directly Targeting MAGI2
Mengtao Ma, Miao He, Qian Jiang, Yuanyuan Yan, Shu Guan, Jing Zhang, Zhaojin Yu, Qiuchen Chen, Mingli Sun, Weifan Yao, Haishan Zhao, Feng Jin, Minjie Wei
Int. J. Biol. Sci. 2016; 12(4): 397-408. doi:10.7150/ijbs.13475
[Abstract] [Full text] [PDF] [PubMed] [PMC]


MiRNA Transcriptome Profiling of Spheroid-Enriched Cells with Cancer Stem Cell Properties in Human Breast MCF-7 Cell Line
Lily Boo, Wan Yong Ho, Norlaily Mohd Ali, Swee Keong Yeap, Huynh Ky, Kok Gan Chan, Wai Fong Yin, Dilan Amila Satharasinghe, Woan Charn Liew, Sheau Wei Tan, Han Kiat Ong, Soon Keng Cheong
Int. J. Biol. Sci. 2016; 12(4): 427-445. doi:10.7150/ijbs.12777
[Abstract] [Full text] [PDF] [PubMed] [PMC]


A Phase II Clinical Trial of Concurrent Helical Tomotherapy plus Cetuximab Followed by Adjuvant Chemotherapy with Cisplatin and Docetaxel for Locally Advanced Nasopharyngeal Carcinoma
Xinxin Zhang, Lei Du, Feifang Zhao, Qiuju Wang, Shiming Yang, Lin Ma
Int. J. Biol. Sci. 2016; 12(4): 446-453. doi:10.7150/ijbs.12937
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Alternative Roles of STAT3 and MAPK Signaling Pathways in the MMPs Activation and Progression of Lung Injury Induced by Cigarette Smoke Exposure in ACE2 Knockout Mice
Yi-Han Hung, Wen-Yeh Hsieh, Jih-Sheng Hsieh, Fon-Chang Liu, Chin-Hung Tsai, Li-Che Lu, Chen-Yi Huang, Chien-Liang Wu, Chih-Sheng Lin
Int. J. Biol. Sci. 2016; 12(4): 454-465. doi:10.7150/ijbs.13379
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Hyperglycemia Differentially Affects Maternal and Fetal DNA Integrity and DNA Damage Response
Jusciele B. Moreli, Janine H. Santos, Aline Rodrigues Lorenzon-Ojea, Simone Corrêa-Silva, Rodrigo S. Fortunato, Clarissa Ribeiro Rocha, Marilza V. Rudge, Débora C. Damasceno, Estela Bevilacqua, Iracema M. Calderon
Int. J. Biol. Sci. 2016; 12(4): 466-477. doi:10.7150/ijbs.12815
[Abstract] [Full text] [PDF] [PubMed] [PMC]



CPT-cGMP Is A New Ligand of Epithelial Sodium Channels
Hong-Long Ji, Hong-Guang Nie, Yongchang Chang, Qizhou Lian, Shan-Lu Liu
Int. J. Biol. Sci. 2016; 12(4): 359-366. doi:10.7150/ijbs.13764
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Therapeutic Rationales, Progresses, Failures, and Future Directions for Advanced Prostate Cancer
Kristine M Wadosky, Shahriar Koochekpour
Int. J. Biol. Sci. 2016; 12(4): 409-426. doi:10.7150/ijbs.14090
[Abstract] [Full text] [PDF] [PubMed] [PMC]