BRCA1, Hormone, and Tissue-Specific Tumor Suppression

Hu, Yanfen

doi:10.7150/ijbs.5.20

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Theranostics

International Journal of Medical Sciences

Nanotheranostics

Journal of Cancer

Journal of Genomics

Global reach, higher impact

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Int J Biol Sci 2009; 5(1):20-27. doi:10.7150/ijbs.5.20 This issue Cite

Review

BRCA1, Hormone, and Tissue-Specific Tumor Suppression

Yanfen Hu^✉

Department of Molecular Medicine/Institute of Biotechnology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78245, USA

Citation:

Hu Y. BRCA1, Hormone, and Tissue-Specific Tumor Suppression. Int J Biol Sci 2009; 5(1):20-27. doi:10.7150/ijbs.5.20. https://www.ijbs.com/v05p0020.htm

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Abstract

Germline mutations of BRCA1 predispose women to breast and ovarian cancers. Elucidating molecular mechanism of tissue- and gender-specific phenomena in BRCA1-related tumors is a key to our understanding of BRCA1 function in tumor suppression. This review summarizes studies in recent years on the link between BRCA1 and estrogen/progesterone signaling pathways, as well as discusses various models underscoring a triangle relationship among BRCA1, estrogen and genome instability.

Keywords: BRCA1, tumor suppression, estrogen, genome instability.

Citation styles

APA

Hu, Y. (2009). BRCA1, Hormone, and Tissue-Specific Tumor Suppression. International Journal of Biological Sciences, 5(1), 20-27. https://doi.org/10.7150/ijbs.5.20.

ACS

Hu, Y. BRCA1, Hormone, and Tissue-Specific Tumor Suppression. Int. J. Biol. Sci. 2009, 5 (1), 20-27. DOI: 10.7150/ijbs.5.20.

NLM

Hu Y. BRCA1, Hormone, and Tissue-Specific Tumor Suppression. Int J Biol Sci 2009; 5(1):20-27. doi:10.7150/ijbs.5.20. https://www.ijbs.com/v05p0020.htm

CSE

Hu Y. 2009. BRCA1, Hormone, and Tissue-Specific Tumor Suppression. Int J Biol Sci. 5(1):20-27.

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