Volume 22, Issue 12

open access Global reach, higher impact

Volume 22 (12); 2026

Research Papers

Intestine-specific Faf2 depletion ameliorates obesity and metabolic dysfunction-associated steatotic liver disease by impairing lipid absorption Jingjing Zhang, Norihiro Imai, Jinglei Cheng, Akiko Sugiyama, Hanna Kawecka, Dongming Liu, Michitaka Suzuki, Yuki Ohsaki, Shinya Yokoyama, Kenta Yamamoto, Takanori Ito, Keiko Maeda, Yoji Ishizu, Takashi Honda, Tetsuya Ishikawa, Michał Woźniak, Hiroaki Wake, David E. Cohen, Hiroki Kawashima Int. J. Biol. Sci. 2026; 22(12): 6261-6280. doi:10.7150/ijbs.134379 Full text PDF

Targeting Netrin-1 Mediates the Suppression of Osteolytic Bone Metastasis in Breast Cancer by Ugonin L Trung-Loc Ho, Wei-Cheng Chen, Chun-Lin Liu, Kuan-Ying Lai, Chih-Chuang Liaw, Lan-Yun Chang, Chih-Hao Lu, Hsiao-Chi Tsai, Yi-Chin Fong, Jeng-Hung Guo, Tzu-Min Huang, Chih-Ying Wu, Chih-Hsin Tang Int. J. Biol. Sci. 2026; 22(12): 6298-6315. doi:10.7150/ijbs.128973 Full text PDF

ALYREF-mediated m⁵C modification of CCNA1 drives escape from cell-cycle arrest and contributes to pazopanib resistance in Renal Cell Carcinoma Zeyi Lu, Yang Li, Ziwei Zhu, Fan Li, Yiming Ding, Lifeng Ding, Ruyue Wang, Yudong Lin, Wenqin Luo, Xudong Mao, Haohua Lu, Yejinpeng Wang, Mengxuan Li, Yuanlei Chen, Zhehao Xu, Yi Lu, Qiming Zheng, Haiyun Xie, Zhenwei Zhou, Liqun Xia, Gonghui Li, Mingchao Wang Int. J. Biol. Sci. 2026; 22(12): 6319-6337. doi:10.7150/ijbs.131368 Full text PDF

Glycosylation of B7-H3 Promotes CD8⁺ T Cell Exhaustion by Inhibiting the Endosome-Lysosome Pathway in HCC Yifan Yu, Jiaxing Liu, Zhixiong Hao, Yu Li, Guangpeng He, Xuzhe Wang, Liang Yang, Xiaodan Liu, Hangyu Li, Xueqiang Peng Int. J. Biol. Sci. 2026; 22(12): 6338-6362. doi:10.7150/ijbs.126547 Full text PDF

Oridonin targets PRDX1 to promote apoptosis by inducing ROS-mediated ER stress and modulating autophagy Ziyang Ding, Sisi Wang, Junhui Chen, Yali Song, Zhou Zhu, Haibo Tong, Ashok Iyaswamy, Peng Chen, Xu Wei, Wei Zhang, Jigang Wang, Chuanbin Yang, Yulin Feng Int. J. Biol. Sci. 2026; 22(12): 6363-6380. doi:10.7150/ijbs.110208 Full text PDF

Targeting Kupffer Cell CD44-Mediated Ammonia Death via the ELAVL1-GLS Metabolic Circuit in Radiation-Induced Liver Disease Yanyan Lin, Shuxuan Wang, Bufu Tang, Pan Zhou, Xiaojun Zhang, Huanliang Chen, Jiaoyang Yang, Shisuo Du, Qian-Qian Zhao, Zhao-Chong Zeng Int. J. Biol. Sci. 2026; 22(12): 6417-6433. doi:10.7150/ijbs.136823 Full text PDF

Mechanical stress-induced STAT3/YAP signaling in fibroblasts programs immunosuppressive lymph node remodeling in lung squamous carcinoma Jie Cai, Zhao An, Wei Gao, Ryan Li, Zhe-Sheng Chen, An Li, Lei Zhu, Yingran Shen Int. J. Biol. Sci. 2026; 22(12): 6434-6447. doi:10.7150/ijbs.132656 Full text PDF

Loss of Alkbh5 enhances AT2 cell differentiation and alveolar repair across diverse injury models via m⁶A-dependent Areg signaling Jie Lv, Kechen Chen, Xinlong Wang, Yuchen Liu, Lian Li, Shijun Chen, Weiqi Lv, Yanqun Zhang, Yonghao Xu, Qian Liu, Guodong Hu, Zhili Rong, Xin Zhang, Ying Lin Int. J. Biol. Sci. 2026; 22(12): 6465-6482. doi:10.7150/ijbs.130452 Full text PDF

C3G Downregulation Enhances Stemness in Glioblastoma Cells by Promoting PKM2 Upregulation Mateo Cueto-Remacha, Sara Manzano, Minerva Iniesta-González, Jaime Mancebo, Paula Martin-Serna, Nerea Palao, Cristina Baquero, Andrea R. López-Pastor, Cristina Peralbo-Avilés, Alvaro Gutierrez-Uzquiza, Ángel M Cuesta, Paloma Bragado, Carmen Guerrero, Almudena Porras Int. J. Biol. Sci. 2026; 22(12): 6500-6520. doi:10.7150/ijbs.126349 Full text PDF

High density-lipoprotein regulates liquid-liquid phase separation of heat shock protein β-1 by lncRNA HDRACA to affect vascular inflammation and atherosclerosis Zhi-Wei Mo, Yi-Fang Liu, Yi-Xin Zhang, Yan Li, Yang Cao, Chu-Yu Liu, Le Li, Yue-Ting Kang, Hong-Yu Cao, Zhen-Sheng Ma, Yue-Ming Peng, Zhi-Jun Ou, Guang-Qi Chang, Jing-Song Ou Int. J. Biol. Sci. 2026; 22(12): 6521-6538. doi:10.7150/ijbs.135145 Full text PDF

VASN Enhances IGF2BP3 Stability via USP10 Deubiquitination to Promote Triple-negative Breast Cancer Paclitaxel Resistance Hao Liu, Zexiu Lu, Maoshan Chen, Zhenghang Li, Jian Chen, Xingyu Yang, Xueying Wan, Gang Tu, Manran Liu, Lingfeng Tang Int. J. Biol. Sci. 2026; 22(12): 6583-6607. doi:10.7150/ijbs.136403 Full text PDF

Spinal glycine receptor alpha 1 coordinates startle behavior through a cell-type specific mechanism Shoupeng Wei, Jiyi Xu, Shao-Rui Chen, Yuying Huang, Zev Jarrett, Grzegorz Godlewski, Janos Paloczi, Pal Pacher, Hui-Lin Pan, Yan Xu, David M. Lovinger, Li Zhang Int. J. Biol. Sci. 2026; 22(12): 6631-6652. doi:10.7150/ijbs.132688 Full text PDF

Targeting Ash1L-STING Axis Restores NK Cell Function and Ameliorates Immune-Mediated Bone Marrow Failure Diseases Nan Song, Yi Cui, Li He, Xinrui Zhang, Yiyu Guo, Xinru Wu, Yu Gao, Chunyan Liu, Rong Fu Int. J. Biol. Sci. 2026; 22(12): 6653-6669. doi:10.7150/ijbs.131763 Full text PDF

SYNCRIP drives ferroptosis resistance and metabolic activation via SIRT1 and HK2 in glioblastoma Hyeon Ji Kim, Hyo-Jin Song, Yu Gyung Kim, Mingyu Kang, Tae-Jun Kim, Jin-Seok Byun, Do-Yeon Kim Int. J. Biol. Sci. 2026; 22(12): 6670-6688. doi:10.7150/ijbs.127096 Full text PDF

ACSL5 programs fatty acid metabolism and mitochondrial fitness to sustain pathogenic T cells and exacerbate Sjögren's syndrome Xinyi Ren, Junhao Yin, Xinyi Ma, Jiabao Xu, Changyu Chen, Lele He, Ruowen Zhao, Yucheng Xu, Yiping Pu, Baoli Wang, Jiayao Fu, Lingyan Zheng Int. J. Biol. Sci. 2026; 22(12): 6689-6708. doi:10.7150/ijbs.131033 Full text PDF

MTUS2-AS1 suppression promotes DDX5 protein degradation to enhance the sensitivity of PARP inhibitors in BRCA-wild triple negative breast cancer Tao Xu, Junjie Nie, Bei Pan, Qiwei Hong, Yujing Fan, Lei Dong, Jian Qin, Huiling Sun, Mu Xu, Yuqin Pan, Shukui Wang Int. J. Biol. Sci. 2026; 22(12): 6735-6751. doi:10.7150/ijbs.133410 Full text PDF

Butyrate enhances tumor immune evasion by increasing PD-L1 abundance Xue Sun, Yi Gao, Jiaxi Li, Yan Ma, Hongchen Li, Zhen Wang, Lei Lv, Yanping Xu Int. J. Biol. Sci. 2026; 22(12): 6752-6766. doi:10.7150/ijbs.131184 Full text PDF

Endothelial Senescence-Associated Secretory Signaling Promotes Macrophage Extracellular Traps Formation and Contributes to the Exacerbation of Combined Lung Injury Wentao Xie, Hongsen Liao, Yali Dai, Lin Chen, Yujie Li, Zhuo Cheng, Chunmeng Shi Int. J. Biol. Sci. 2026; 22(12): 6790-6813. doi:10.7150/ijbs.133943 Full text PDF

HLA class I-specific nucleolin peptides induce therapeutic T cells in triple-negative breast cancer patients Suyanee Thongchot, Niphat Jirapongwattana, Thaweesak Chieochansin, Jaturawitt Prasopsiri, Wannasiri Chiraphapphaiboon, Piriya Luangwattananun, Thanyada Rungrotmongkol, Kamonpan Sanachai, Nitchakan Darai, Doonyapat Sa-nguanraksa, Pornchai O-Charoenrat, Peti Thuwajit, Pa-thai Yenchitsomanus, Chanitra Thuwajit Int. J. Biol. Sci. 2026; 22(12): 6814-6835. doi:10.7150/ijbs.132389 Full text PDF

Single-cell atlas of rhesus monkey testis reveals aging- and season-dependent regulation of spermatogenesis and microenvironment homeostasis Shengnan Wang, Yichao Wang, Li Wu, Xiang Shi, Yaping Yan, Lei Zhang, Weizhi Ji, Naixue Yang, Wei Si Int. J. Biol. Sci. 2026; 22(12): 6858-6875. doi:10.7150/ijbs.134245 Full text PDF

Reviews

Complex Roles of Insect Cytochrome P450s in Chemical Adaptation Qi-Ren Chen, Timothy W. Moural, Fang Zhu Int. J. Biol. Sci. 2026; 22(12): 6281-6297. doi:10.7150/ijbs.135523 Full text PDF

Exploring Lipid Metabolic Reprogramming: Mechanistic Insights and Implications for Tumor Radiotherapy Ruiqiu Zhu, Ying Wan, Jinrong Wei, Limin Jin, Yuntian Shen, Yaqun Zhu, Qiliang Peng Int. J. Biol. Sci. 2026; 22(12): 6381-6416. doi:10.7150/ijbs.133227 Full text PDF

Nuclear Mechanotransduction at the Crossroads: How Membrane Receptors Remodel the Perinuclear Cytoskeleton to Drive Cancer and Disease Michela Sgarzi, Elisa Montacci, Martina Mazzeschi, Alessandra Morselli, Mattia Lauriola Int. J. Biol. Sci. 2026; 22(12): 6448-6464. doi:10.7150/ijbs.127556 Full text PDF

The Muscle-Liver Immunometabolic Axis in Liver Transplantation: A Decisive Role in Outcomes and Mechanisms Zhu Li, Jinyan Chen, Huigang Li, Yuhang Li, Peiru Zhang, Yiyu Chen, Rongsen Wang, Ke Yang, Ximing Wang, Xinjun Zhuang, Yiming Su, Jinxin Xu, Shusen Zheng, Xiao Xu, Di Lu Int. J. Biol. Sci. 2026; 22(12): 6483-6499. doi:10.7150/ijbs.132050 Full text PDF

In vivo delivery strategies for therapeutic CRISPR genome editing Leonardo Martin, Jure Bohinc, Alessandra Recchia, Stefano Gritti, Giorgia Santilli, Joanna Zeyland, Melita Vidaković, Nevena Grdović, Karim Benabdellah, María Ortiz-Bueno, Bilge Debelec Butuner, Luana Pisaniello, Roberta Stilhano, Daniela Benati, Fatma Zehra Hapil, Shariqa Khawaja, Rajeevkumar Raveendran Nair, Carla Giacomelli, Erden Atilla, Federica Zinghirino, Tommaso Ferrari, Federico Corradi, Tamas J. Laufer, Denis Khnykin, Gloria González Aseguinolaza, Mojca Skrbinek, Tjaša Mlakar, Tjaša Lapanja, Duško Lainšček Int. J. Biol. Sci. 2026; 22(12): 6539-6581. doi:10.7150/ijbs.133162 Full text PDF

Intracellular PD-L1: Functions, Regulation, and Therapeutic Implications Youliang Zhao, Yaqian Qu, Changfu Hao, Wu Yao Int. J. Biol. Sci. 2026; 22(12): 6608-6630. doi:10.7150/ijbs.133650 Full text PDF

From Host-Microbiome Symbiosis to Clinical Translation: A Gut Microbiome Perspective on Radiation Enteritis Jieru Zhuang, Yun Zhong, Zhongyao Lin, Yongjun Lu, Hui Wang, Lingming Chen, Keli Yang, Delin Tan, Yunyi Qiu, Yuanxin Zhang, Huaiming Wang, Zhenhuang Ge Int. J. Biol. Sci. 2026; 22(12): 6709-6734. doi:10.7150/ijbs.134169 Full text PDF

Cleaning, Chasing and Calming: Promising Paradigms of Senotherapy in Aging-Related Diseases Shasha Ran, Siyu Zhou, Haotian Ma, Fang Zhang, Yanrui Yang, Maiheliya Abulajiang, Xiujuan Yang, Shanshan Li, Qixiong Zhang Int. J. Biol. Sci. 2026; 22(12): 6767-6789. doi:10.7150/ijbs.138243 Full text PDF

The Metabolic-Immune Axis: Amino Acids and Immune Cell Dynamics in Mammary Gland Development and Remodeling Xiangyang Ye, Ziwei Xu, Yating Chen, Yusheng Lu, Li Wang, Hao Xiao Int. J. Biol. Sci. 2026; 22(12): 6836-6857. doi:10.7150/ijbs.138760 Full text PDF

Commentary

Immune Imprinting and Antigenic Drift as Determinants of SARS-CoV-2 Vaccine Performance Seung-Jae Lee, Jaehoon Bae, Sang Hoon Lee Int. J. Biol. Sci. 2026; 22(12): 6316-6318. doi:10.7150/ijbs.130233 Full text PDF