Int J Biol Sci 2011; 7(5):664-672. doi:10.7150/ijbs.7.664
SRC-3 Has a Role in Cancer Other Than as a Nuclear Receptor Coactivator
Department of Surgical Oncology, the First Affiliated Hospital, Medical School, Xi'an Jiaotong University, Xi'an, Shaanxi Province, 710061, P. R. China
Ma G, Ren Y, Wang K, He J. SRC-3 Has a Role in Cancer Other Than as a Nuclear Receptor Coactivator. Int J Biol Sci 2011; 7(5):664-672. doi:10.7150/ijbs.7.664. Available from http://www.ijbs.com/v07p0664.htm
Steroid receptor coactivator-3 (SRC-3), also known as AIB1, is a member of the p160 steroid receptor coactivator family. Since SRC-3 was found to be amplified in breast cancer in 1997, the role of SRC-3 in cancer has been broadly investigated. SRC-3 initially was identified as a transcriptional coactivator for nuclear receptors such as the estrogen receptor (ER), involved in the proliferation of hormone-dependent cancers. However, increasing clinical evidence shows that dysregulation of SRC-3 expression in several human hormone-independent cancers is correlated with pathological factors and clinical prognosis. Recently, both in vivo and in vitro studies demonstrate that SRC-3 may influence a number of cancer cellular processes in several ways independent of nuclear receptor signaling. In addition, an SRC-3 transgenic mice model shows that SRC-3 induces tumors in several mouse tissues. These results indicate that the role of SRC-3 in cancer is not just as a nuclear receptor coactivator. The focus of this review is to examine possible SRC-3 roles in cancer, other than as a nuclear receptor coactivator.
Keywords: Steroid receptor coactivator-3, mice model, tumorigenesis, cell cycle, apoptosis, invasion and metastasis