Role of Co-stimulation in Leishmaniasis

Tuladhar, Rashmi; Natarajan, Gayathri; Satoskar, Abhay R

doi:10.7150/ijbs.7.1382

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Int J Biol Sci 2011; 7(9):1382-1390. doi:10.7150/ijbs.7.1382 This issue Cite

Review

Role of Co-stimulation in Leishmaniasis

Rashmi Tuladhar^1,2, Gayathri Natarajan^1,2, Abhay R Satoskar^{1,2 ✉}

1. Department of Microbiology, The Ohio State University, Columbus, Ohio 43221, USA.
2. Department of Pathology, The Ohio State University, Columbus, Ohio 43221, USA.

Citation:

Tuladhar R, Natarajan G, Satoskar AR. Role of Co-stimulation in Leishmaniasis. Int J Biol Sci 2011; 7(9):1382-1390. doi:10.7150/ijbs.7.1382. https://www.ijbs.com/v07p1382.htm

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Abstract

Leishmania are obligate intracellular parasites that cause a wide spectrum of diseases ranging from cutaneous, mucocutaneous and the visceral kind. Persistence or resolution of leishmaniasis is governed by host immune response. Co-stimulation is an important secondary signal that governs the extent, strength and direction of the immune response that follows. Co-stimulation by CD40, B7 and OX40 family has been shown to influence the outcome following Leishmania infection and manipulation of these pathways has shown promise for use in immune therapy of leishmaniasis. In this review, we discuss the roles of CD40, B7 and OX40 co-stimulatory pathways in regulating immunity to Leishmania and their implications in the treatment of this disease.

Keywords: Leishmaniasis, Leishmania, co-stimulatory pathways, immunity

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APA

Tuladhar, R., Natarajan, G., Satoskar, A.R. (2011). Role of Co-stimulation in Leishmaniasis. International Journal of Biological Sciences, 7(9), 1382-1390. https://doi.org/10.7150/ijbs.7.1382.

ACS

Tuladhar, R.; Natarajan, G.; Satoskar, A.R. Role of Co-stimulation in Leishmaniasis. Int. J. Biol. Sci. 2011, 7 (9), 1382-1390. DOI: 10.7150/ijbs.7.1382.

NLM

Tuladhar R, Natarajan G, Satoskar AR. Role of Co-stimulation in Leishmaniasis. Int J Biol Sci 2011; 7(9):1382-1390. doi:10.7150/ijbs.7.1382. https://www.ijbs.com/v07p1382.htm

CSE

Tuladhar R, Natarajan G, Satoskar AR. 2011. Role of Co-stimulation in Leishmaniasis. Int J Biol Sci. 7(9):1382-1390.

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