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Int J Biol Sci 2012; 8(6):811-818. doi:10.7150/ijbs.4439 This issue Cite

Research Paper

Human Circulating MicroRNA-1 and MicroRNA-126 as Potential Novel Indicators for Acute Myocardial Infarction

Guangwen Long*, Feng Wang*, Quanlu Duan, Fuqiong Chen, Shenglan Yang, Wei Gong, Yan Wang, Chen Chen✉, Dao Wen Wang✉

Department of Internal Medicine and the Institute of Hypertension, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, People's Republic of China.
* contributed equally to this study.

✉ Corresponding author: Dao Wen Wang, MD, PhD or Chen Chen, MD, PhD. Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095# Jiefang Ave., Wuhan, 430030, P. R. China. Tel and Fax: More

Citation:
Long G, Wang F, Duan Q, Chen F, Yang S, Gong W, Wang Y, Chen C, Wang DW. Human Circulating MicroRNA-1 and MicroRNA-126 as Potential Novel Indicators for Acute Myocardial Infarction. Int J Biol Sci 2012; 8(6):811-818. doi:10.7150/ijbs.4439. https://www.ijbs.com/v08p0811.htm
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Abstract

Circulating miRNAs have been shown as promising biomarkers for various pathologic conditions. The aim of this study was to clarify that circulating miR-1 and miR-126 in human plasma might be useful as biomarkers in acute myocardial infarction (AMI). In our study, after pre-test, two candidate miRNAs were detected by using real-time RT-PCR. Cardiac troponin I (cTnI) concentrations were measured by ELISA assay in plasma from patients with AMI (n=17) and healthy subjects (n=25), simultaneously. Increased miR-1 and decreased miR-126 in plasma from patients with AMI after the onset of symptoms compared with healthy subjects were found. A remarkable finding in this study is that miR-1, miR-126 and cTnI expression levels exhibited the same trend. Our results suggest that the plasma concentrations of miR-1 and miR-126 may be useful indicators for AMI.

Keywords: circulating miRNA, biomarker, AMI.

Citation styles

APA
Long, G., Wang, F., Duan, Q., Chen, F., Yang, S., Gong, W., Wang, Y., Chen, C., Wang, D.W. (2012). Human Circulating MicroRNA-1 and MicroRNA-126 as Potential Novel Indicators for Acute Myocardial Infarction. International Journal of Biological Sciences, 8(6), 811-818. https://doi.org/10.7150/ijbs.4439.

ACS
Long, G.; Wang, F.; Duan, Q.; Chen, F.; Yang, S.; Gong, W.; Wang, Y.; Chen, C.; Wang, D.W. Human Circulating MicroRNA-1 and MicroRNA-126 as Potential Novel Indicators for Acute Myocardial Infarction. Int. J. Biol. Sci. 2012, 8 (6), 811-818. DOI: 10.7150/ijbs.4439.

NLM
Long G, Wang F, Duan Q, Chen F, Yang S, Gong W, Wang Y, Chen C, Wang DW. Human Circulating MicroRNA-1 and MicroRNA-126 as Potential Novel Indicators for Acute Myocardial Infarction. Int J Biol Sci 2012; 8(6):811-818. doi:10.7150/ijbs.4439. https://www.ijbs.com/v08p0811.htm

CSE
Long G, Wang F, Duan Q, Chen F, Yang S, Gong W, Wang Y, Chen C, Wang DW. 2012. Human Circulating MicroRNA-1 and MicroRNA-126 as Potential Novel Indicators for Acute Myocardial Infarction. Int J Biol Sci. 8(6):811-818.

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