Int J Biol Sci 2015; 11(2):168-175. doi:10.7150/ijbs.10464 This issue


Biology of IL-27 and its Role in the Host Immunity against Mycobacterium Tuberculosis

Abualgasim Elgaili Abdalla1, 2, Qiming Li1, Longxiang Xie1, Jianping Xie1✉

1. Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, Key Laboratory of Eco-environments in Three Gorges Reservoir Region, Ministry of Education, School of Life Sciences, Southwest University, Beibei, Chongqing 400715, China.
2. Department of Clinical Microbiology, College of Medical Laboratory Sciences, Omdurman Islamic University, Omdurman, Khartoum, Sudan.

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Abdalla AE, Li Q, Xie L, Xie J. Biology of IL-27 and its Role in the Host Immunity against Mycobacterium Tuberculosis. Int J Biol Sci 2015; 11(2):168-175. doi:10.7150/ijbs.10464. Available from

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Graphic abstract

IL-27, a heterodimeric cytokine of IL-12 family, regulates both innate and adaptive immunity largely via Jak-Stat signaling. IL-27 can induce IFN-γ and inflammatory mediators from T lymphocytes and innate immune cells. IL-27 has unique anti-inflammatory properties via both Tr1 cells dependent and independent mechanisms. Here the role and biology of IL-27 in innate and adaptive immunity are summarized, with special interest with immunity against Mycobacterium tuberculosis.

Keywords: IL-27, IL-27Rα, IL-12 family, Mycobacterium tuberculosis, Immunity