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Int J Biol Sci 2020; 16(13):2454-2463. doi:10.7150/ijbs.47142 This issue Cite

Review

Role of Hippo-YAP1/TAZ pathway and its crosstalk in cardiac biology

Xiaoqing Chen^1*, Wenchang Yuan^2*, Yilang Li¹, Jiandong Luo^1✉, Ning Hou^1✉

1. Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou 511436, China;
2. KingMed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou 511436, China.
^*These authors contributed equally to this work.

✉ Corresponding authors: Ning Hou, Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou 511436, China. E-mail address: houningedu.cn. Jiandong Luo, Guangzhou Institute of Cardiovascular Disease, Guangzhou Key Laboratory of Cardiovascular Disease, and the Second Affiliated Hospital, Guangzhou Medical University, Guangzhou 510260, P.R. China. E-mail address: jiandongluocom. More

Abstract

The Hippo pathway undertakes a pivotal role in organ size control and the process of physiology and pathology in tissue. Its downstream effectors YAP1 and TAZ receive upstream stimuli and exert transcription activity to produce biological output. Studies have demonstrated that the Hippo pathway contributes to maintenance of cardiac homeostasis and occurrence of cardiac disease. And these cardiac biological events are affected by crosstalk among Hippo-YAP1/TAZ, Wnt/β-catenin, Bone morphogenetic protein (BMP) and G-protein-coupled receptor (GPCR) signaling, which provides new insights into the Hippo pathway in heart. This review delineates the interaction among Hippo, Wnt, BMP and GPCR pathways and discusses the effects of these pathways in cardiac biology.

Keywords: Hippo pathway, Wnt signaling, BMP signaling, GPCR signaling, cardiac biology

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