Int J Biol Sci 2021; 17(1):368-378. doi:10.7150/ijbs.52169 This issue


Niche Cells Crosstalk In Neuroinflammation After Traumatic Brain Injury

Yibin Jia1#, Guanyi Wang1#, Yuqing Ye1,2#, Enming Kang1, Huijun Chen1, Zishuo Guo3, Xiaosheng He1✉

1. Department of Neurosurgery, Xijing Hospital, Airforce Military Medical University (Fourth Military Medical University), Xi'an 710032, China
2. Department of Neurosurgery, PLA 163rd Hospital (Second Affiliated Hospital of Hunan Normal University), Changsha 410000, China
3. State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, AMMS, Beijing 100071, China
# These authors contributed equally to this work

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Jia Y, Wang G, Ye Y, Kang E, Chen H, Guo Z, He X. Niche Cells Crosstalk In Neuroinflammation After Traumatic Brain Injury. Int J Biol Sci 2021; 17(1):368-378. doi:10.7150/ijbs.52169. Available from

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Graphic abstract

Traumatic brain injury (TBI) is recognized as the disease with high morbidity and disability around world in spite of the work ongoing in neural protection. Due to heterogeneity among the patients, it's still hard to acquire satisfying achievements in clinic. Neuroinflammation, which exists since primary injury occurs, with elusive duality, appear to be of significance from recovery of injury to neurogenesis. In recent years, studied have revealed that communication in neurogenic niche is more than “cell to cell” communication, and study on NSCs represent it as central role in the progress of neural regeneration. Hence, the neuroinflammation-affecting crosstalk after TBI, and clarifying definitive role of NSCs in the course of regeneration is a promising subject for researchers, for its great potential in overcoming the frustrating status quo in clinic, promoting welfare of TBI patient.

Keywords: Traumatic brain injury, Neuroinflammation, Nerve regeneration, Extracellular vesicles, Microglia, Astrocytes, Neural stem cell (NSC)