Int J Biol Sci 2021; 17(9):2308-2322. doi:10.7150/ijbs.59876 This issue


miR-223: An Effective Regulator of Immune Cell Differentiation and Inflammation

Peng Jiao1,2#, Xing-Ping Wang1,2#, Zhuo-Ma Luoreng1,2✉, Jian Yang1,2, Li Jia1,2, Yun Ma1,2, Da-Wei Wei1,2

1. School of Agriculture, Ningxia University, Yinchuan 750021, China.
2. Key Laboratory of Ruminant Molecular Cell Breeding, Ningxia Hui Autonomous Region, Yinchuan 750021, China.
#These authors contributed equally to this work.

This is an open access article distributed under the terms of the Creative Commons Attribution License ( See for full terms and conditions.
Jiao P, Wang XP, Luoreng ZM, Yang J, Jia L, Ma Y, Wei DW. miR-223: An Effective Regulator of Immune Cell Differentiation and Inflammation. Int J Biol Sci 2021; 17(9):2308-2322. doi:10.7150/ijbs.59876. Available from

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Graphic abstract

MicroRNAs (miRNAs) play a critical role in regulating various biological processes, such as cell differentiation and immune modulation by binding to their target genes. miR-223 is a miRNA with important functions and has been widely investigated in recent years. Under certain physiological conditions, miR-223 is regulated by different transcription factors, including sirtuin1 (Sirt1), PU.1 and Mef2c, and its biological functions are mediated through changes in its cellular or tissue expression. This review paper summarizes miR-223 biosynthesis and its regulatory role in the differentiation of granulocytes, dendritic cells (DCs) and lymphocytes, macrophage polarization, and endothelial and epithelial inflammation. In addition, it describes the molecular mechanisms of miR-223 in regulating lung inflammation, rheumatoid arthritis, enteritis, neuroinflammation and mastitis to provide insights into the existing molecular regulatory networks and therapies for inflammatory diseases in humans and animals.

Keywords: miR-223, Cellular inflammation, Inflammatory diseases, Immunity, Molecular regulatory network