Role of mismatch repair in aging

Wen, Jie; Wang, Yangyang; Yuan, Minghao; Huang, Zhenting; Zou, Qian; Pu, Yinshuang; Zhao, Bin; Cai, Zhiyou

doi:10.7150/ijbs.64953

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Int J Biol Sci 2021; 17(14):3923-3935. doi:10.7150/ijbs.64953 This issue Cite

Review

Role of mismatch repair in aging

Jie Wen^1,2,3,4, Yangyang Wang^1,2, Minghao Yuan^1,2, Zhenting Huang^1,2, Qian Zou^1,2, Yinshuang Pu^1,2, Bin Zhao^3,4✉, Zhiyou Cai^1,2✉

1. Chongqing Key Laboratory of Neurodegenerative Diseases, Chongqing, 400013, China.
2. Department of Neurology, Chongqing General Hospital, University of Chinese Academy of Sciences, Chongqing, 400013, China.
3. Department and Institute of Neurology, Guangdong Medical University, Guangdong, 524001, China.
4. Guangdong Key Laboratory of aging related cardio cerebral diseases, Guangdong, 524001, China.

✉ Corresponding authors: Zhiyou Cai & Bin Zhao. Zhiyou Cai: Department of Neurology, Chongqing General Hospital, University of Chinese Academy of Sciences. No. 312 Zhongshan First Road, Yuzhong District, Chongqing, People's Republic of China, 4000 More

Citation:

Wen J, Wang Y, Yuan M, Huang Z, Zou Q, Pu Y, Zhao B, Cai Z. Role of mismatch repair in aging. Int J Biol Sci 2021; 17(14):3923-3935. doi:10.7150/ijbs.64953. https://www.ijbs.com/v17p3923.htm

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Abstract

A common feature of aging is the accumulation of genetic damage throughout life. DNA damage can lead to genomic instability. Many diseases associated with premature aging are a result of increased accumulation of DNA damage. In order to minimize these damages, organisms have evolved a complex network of DNA repair mechanisms, including mismatch repair (MMR). In this review, we detail the effects of MMR on genomic instability and its role in aging emphasizing on the association between MMR and the other hallmarks of aging, serving to drive or amplify these mechanisms. These hallmarks include telomere attrition, epigenetic alterations, mitochondrial dysfunction, altered nutrient sensing and cell senescence. The close relationship between MMR and these markers may provide prevention and treatment strategies, to reduce the incidence of age-related diseases and promote the healthy aging of human beings.

Keywords: aging, mismatch repair, genomic instability, telomere attrition, epigenetic alterations, mitochondrial dysfunction

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APA

Wen, J., Wang, Y., Yuan, M., Huang, Z., Zou, Q., Pu, Y., Zhao, B., Cai, Z. (2021). Role of mismatch repair in aging. International Journal of Biological Sciences, 17(14), 3923-3935. https://doi.org/10.7150/ijbs.64953.

ACS

Wen, J.; Wang, Y.; Yuan, M.; Huang, Z.; Zou, Q.; Pu, Y.; Zhao, B.; Cai, Z. Role of mismatch repair in aging. Int. J. Biol. Sci. 2021, 17 (14), 3923-3935. DOI: 10.7150/ijbs.64953.

NLM

Wen J, Wang Y, Yuan M, Huang Z, Zou Q, Pu Y, Zhao B, Cai Z. Role of mismatch repair in aging. Int J Biol Sci 2021; 17(14):3923-3935. doi:10.7150/ijbs.64953. https://www.ijbs.com/v17p3923.htm

CSE

Wen J, Wang Y, Yuan M, Huang Z, Zou Q, Pu Y, Zhao B, Cai Z. 2021. Role of mismatch repair in aging. Int J Biol Sci. 17(14):3923-3935.

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