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Int J Biol Sci 2022; 18(4):1695-1705. doi:10.7150/ijbs.64982 This issue Cite

Review

Regulation of Ferroptosis by Amino Acid Metabolism in Cancer

Jian Yang*, Xinyu Dai*, Huanji Xu, Qiulin Tang, Feng Bi✉

Department of Medical Oncology, Cancer Center and Laboratory of Molecular Targeted Therapy in Oncology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, 610041, China.
*These authors contributed equally to this work.

✉ Corresponding author: E-mail: bifengedu.cn (F. Bi).

Citation:
Yang J, Dai X, Xu H, Tang Q, Bi F. Regulation of Ferroptosis by Amino Acid Metabolism in Cancer. Int J Biol Sci 2022; 18(4):1695-1705. doi:10.7150/ijbs.64982. https://www.ijbs.com/v18p1695.htm
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Abstract

Graphic abstract

Ferroptosis, a new form of programmed necrosis characterized by iron-dependent lethal accumulation of lipid hydroperoxides, is associated with many human diseases. Targeting amino acid (AA) availability can selectively suppress tumor growth and has been a promising therapeutic strategy for cancer therapy. Compelling studies have indicated that AA metabolism is also involved in ferroptosis, closely regulating its initiation and execution. This manuscript systematically summarizes the latest advances of AA metabolism in regulating ferroptosis and discusses the potential combination of therapeutic strategies that simultaneously target AA metabolism and ferroptosis in cancer to eliminate tumors or limit their invasiveness.

Keywords: amino acid metabolism, ferroptosis, cancer, combinatorial therapy

Citation styles

APA
Yang, J., Dai, X., Xu, H., Tang, Q., Bi, F. (2022). Regulation of Ferroptosis by Amino Acid Metabolism in Cancer. International Journal of Biological Sciences, 18(4), 1695-1705. https://doi.org/10.7150/ijbs.64982.

ACS
Yang, J.; Dai, X.; Xu, H.; Tang, Q.; Bi, F. Regulation of Ferroptosis by Amino Acid Metabolism in Cancer. Int. J. Biol. Sci. 2022, 18 (4), 1695-1705. DOI: 10.7150/ijbs.64982.

NLM
Yang J, Dai X, Xu H, Tang Q, Bi F. Regulation of Ferroptosis by Amino Acid Metabolism in Cancer. Int J Biol Sci 2022; 18(4):1695-1705. doi:10.7150/ijbs.64982. https://www.ijbs.com/v18p1695.htm

CSE
Yang J, Dai X, Xu H, Tang Q, Bi F. 2022. Regulation of Ferroptosis by Amino Acid Metabolism in Cancer. Int J Biol Sci. 18(4):1695-1705.

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