ISSN: 1449-2288International Journal of Biological Sciences
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Int J Biol Sci 2023; 19(15):4831-4832. doi:10.7150/ijbs.89237 This issue Cite
Commentary
p53 and MYC-regulated squalene epoxidase as Achilles heel in colorectal cancer
Computational Biology Group, Leibniz Institute on Aging - Fritz Lipmann Institute (FLI), Beutenbergstraße 11, 07745 Jena, Germany
Citation:
Fischer M. p53 and MYC-regulated squalene epoxidase as Achilles heel in colorectal cancer. Int J Biol Sci 2023; 19(15):4831-4832. doi:10.7150/ijbs.89237. https://www.ijbs.com/v19p4831.htm
Other stylesCommentary-article in Int J Biol Sci, Volume 19, 4103
Abstract
The transcription factors p53 and MYC are often considered non-druggable targets, but their dysregulation can generate new dependencies and treatment opportunities in cancer cells. The p53 and MYC-regulated squalene epoxidase (SQLE) has been identified as a potential Achilles heel in colorectal cancer. This is of great interest because the FDA-approved anti-fungal SQLE inhibitor Terbinafine could be repurposed to treat colorectal cancer patients.
Keywords: tumor suppressor p53, transcription factor MYC, SQLE, cholesterol synthesis, Terbinafine, colorectal cancer
Citation styles
APA
Fischer, M. (2023). p53 and MYC-regulated squalene epoxidase as Achilles heel in colorectal cancer. International Journal of Biological Sciences, 19(15), 4831-4832. https://doi.org/10.7150/ijbs.89237.
ACS
Fischer, M. p53 and MYC-regulated squalene epoxidase as Achilles heel in colorectal cancer. Int. J. Biol. Sci. 2023, 19 (15), 4831-4832. DOI: 10.7150/ijbs.89237.
NLM
Fischer M. p53 and MYC-regulated squalene epoxidase as Achilles heel in colorectal cancer. Int J Biol Sci 2023; 19(15):4831-4832. doi:10.7150/ijbs.89237. https://www.ijbs.com/v19p4831.htm
CSE
Fischer M. 2023. p53 and MYC-regulated squalene epoxidase as Achilles heel in colorectal cancer. Int J Biol Sci. 19(15):4831-4832.
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