Int J Biol Sci
2011; 7(6):762-768.
doi:10.7150/ijbs.7.762 This issueCite
Research Paper
Identification of MicroRNAs Involved in Hypoxia- and Serum Deprivation-Induced Apoptosis in Mesenchymal Stem Cells
Yu Nie, Bian-Mei Han, Xue-Bin Liu*, Jin-Jing Yang, Fang Wang, Xiang-Feng Cong✉, Xi Chen✉
Research Center for Cardiovascular Regenerative Medicine, Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P. R. China * This author now works in Department of Neural Stem Cell Transplantation, Armed Police General Hospital, Beijing, China.
✉ Corresponding author: Xi Chen & Xiang-Feng Cong, PhD, Research Center for Cardiovascular Regenerative Medicine, Fuwai Hospital, 167 Beishilu Street, Beijing, 100037, China. Tel: +86 010 88398584; Fax: +86 010 88398584; Email: chenxipumccom.cn & xiangfeng_congcom.cnMore
Citation:
Nie Y, Han BM, Liu XB, Yang JJ, Wang F, Cong XF, Chen X. Identification of MicroRNAs Involved in Hypoxia- and Serum Deprivation-Induced Apoptosis in Mesenchymal Stem Cells. Int J Biol Sci 2011; 7(6):762-768. doi:10.7150/ijbs.7.762. https://www.ijbs.com/v07p0762.htm
The use of bone marrow mesenchymal stem cell- (MSC) transplantation therapy for cardiac diseases is limited due to poor survival of implanted cells. MicroRNAs (miRNAs) have been reported to be involved in regulating almost all cellular processes, including apoptosis. In this study, we found that the miRNA profile was altered during apoptosis induced by hypoxia and serum deprivation (hypoxia/SD). We further revealed that over-expression of miR-21, miR-23a and miR-210 could promote the survival of MSCs exposed to hypoxia/SD. In contrast, down-regulation of miR-21, miR-23a and miR-503 aggravated apoptosis of MSCs. It was indicated that these miRNAs may play important roles during MSC apoptosis induced by hypoxia/SD.
Nie, Y., Han, B.M., Liu, X.B., Yang, J.J., Wang, F., Cong, X.F., Chen, X. (2011). Identification of MicroRNAs Involved in Hypoxia- and Serum Deprivation-Induced Apoptosis in Mesenchymal Stem Cells. International Journal of Biological Sciences, 7(6), 762-768. https://doi.org/10.7150/ijbs.7.762.
ACS
Nie, Y.; Han, B.M.; Liu, X.B.; Yang, J.J.; Wang, F.; Cong, X.F.; Chen, X. Identification of MicroRNAs Involved in Hypoxia- and Serum Deprivation-Induced Apoptosis in Mesenchymal Stem Cells. Int. J. Biol. Sci. 2011, 7 (6), 762-768. DOI: 10.7150/ijbs.7.762.
NLM
Nie Y, Han BM, Liu XB, Yang JJ, Wang F, Cong XF, Chen X. Identification of MicroRNAs Involved in Hypoxia- and Serum Deprivation-Induced Apoptosis in Mesenchymal Stem Cells. Int J Biol Sci 2011; 7(6):762-768. doi:10.7150/ijbs.7.762. https://www.ijbs.com/v07p0762.htm
CSE
Nie Y, Han BM, Liu XB, Yang JJ, Wang F, Cong XF, Chen X. 2011. Identification of MicroRNAs Involved in Hypoxia- and Serum Deprivation-Induced Apoptosis in Mesenchymal Stem Cells. Int J Biol Sci. 7(6):762-768.