Identification of MicroRNAs Involved in Hypoxia- and Serum Deprivation-Induced Apoptosis in Mesenchymal Stem Cells

Nie, Yu; Han, Bian-Mei; Liu, Xue-Bin; Yang, Jin-Jing; Wang, Fang; Cong, Xiang-Feng; Chen, Xi

doi:10.7150/ijbs.7.762

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Int J Biol Sci 2011; 7(6):762-768. doi:10.7150/ijbs.7.762 This issue Cite

Research Paper

Identification of MicroRNAs Involved in Hypoxia- and Serum Deprivation-Induced Apoptosis in Mesenchymal Stem Cells

Yu Nie, Bian-Mei Han, Xue-Bin Liu^*, Jin-Jing Yang, Fang Wang, Xiang-Feng Cong^✉, Xi Chen^✉

Research Center for Cardiovascular Regenerative Medicine, Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P. R. China
^* This author now works in Department of Neural Stem Cell Transplantation, Armed Police General Hospital, Beijing, China.

Citation:

Nie Y, Han BM, Liu XB, Yang JJ, Wang F, Cong XF, Chen X. Identification of MicroRNAs Involved in Hypoxia- and Serum Deprivation-Induced Apoptosis in Mesenchymal Stem Cells. Int J Biol Sci 2011; 7(6):762-768. doi:10.7150/ijbs.7.762. https://www.ijbs.com/v07p0762.htm

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Abstract

The use of bone marrow mesenchymal stem cell- (MSC) transplantation therapy for cardiac diseases is limited due to poor survival of implanted cells. MicroRNAs (miRNAs) have been reported to be involved in regulating almost all cellular processes, including apoptosis. In this study, we found that the miRNA profile was altered during apoptosis induced by hypoxia and serum deprivation (hypoxia/SD). We further revealed that over-expression of miR-21, miR-23a and miR-210 could promote the survival of MSCs exposed to hypoxia/SD. In contrast, down-regulation of miR-21, miR-23a and miR-503 aggravated apoptosis of MSCs. It was indicated that these miRNAs may play important roles during MSC apoptosis induced by hypoxia/SD.

Keywords: Mesenchymal stem cells, MicroRNA, Hypoxia/serum deprivation, Apoptosis

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APA

Nie, Y., Han, B.M., Liu, X.B., Yang, J.J., Wang, F., Cong, X.F., Chen, X. (2011). Identification of MicroRNAs Involved in Hypoxia- and Serum Deprivation-Induced Apoptosis in Mesenchymal Stem Cells. International Journal of Biological Sciences, 7(6), 762-768. https://doi.org/10.7150/ijbs.7.762.

ACS

Nie, Y.; Han, B.M.; Liu, X.B.; Yang, J.J.; Wang, F.; Cong, X.F.; Chen, X. Identification of MicroRNAs Involved in Hypoxia- and Serum Deprivation-Induced Apoptosis in Mesenchymal Stem Cells. Int. J. Biol. Sci. 2011, 7 (6), 762-768. DOI: 10.7150/ijbs.7.762.

NLM

CSE

Nie Y, Han BM, Liu XB, Yang JJ, Wang F, Cong XF, Chen X. 2011. Identification of MicroRNAs Involved in Hypoxia- and Serum Deprivation-Induced Apoptosis in Mesenchymal Stem Cells. Int J Biol Sci. 7(6):762-768.

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