Volume 22, Issue 14

open access Global reach, higher impact

Volume 22 (14); 2026

Research Papers

Bazedoxifene Targets gp130 Signaling to Suppress Fibroblast Activation in Pathological Cutaneous Fibrosis: Insights from Spatial Transcriptomics and scRNA-seq Data Zixin Wang, Hanrui Zhang, Liying Tu, Jingjing He, Rong Wang, Yinghong Su, Siwei Tang, Qingfeng Li, Wenzheng Xia, Yashan Gao, Yixuan Zhao, Xin Huang, Tao Zan Int. J. Biol. Sci. 2026; 22(14): 7491-7511. doi:10.7150/ijbs.137778 Full text PDF

Nomilin Rewires mTOR-Driven Immunometabolism via DDIT4 to Restrain Psoriasis Ha Eun Kim, Seung Taek Lee, Hee-Suk Park, Hyun-Su Lee, Jong Yeong Lee, Dae-Ki Kim, Si-Gyun Roh, Kyung-Hwa Nam, Sang-Hyun Kim, Jin Kyeong Choi Int. J. Biol. Sci. 2026; 22(14): 7512-7532. doi:10.7150/ijbs.133330 Full text PDF

Hyperglycemia in Diabetes Drives Hepatic Fibrosis Through the Non-Enzymatic Function of HK2 and AGEs-mediated Matrix Stiffening Chuxin Huang, Jiali Qian, Li Zhang, Ying Liu, Qiwen Zhou, Jiajun Li, Yingying Zhao, Hongmei Yu, Yawen Zhang, Jinya Huang, Miao Li, Ziyu Ren, Zihao Xu, Rui Liu, Xuanchun Wang, Jie Chen, Jiefeng Cui, Yehong Yang Int. J. Biol. Sci. 2026; 22(14): 7533-7556. doi:10.7150/ijbs.130351 Full text PDF

SH2B3 Promotes PD-L1-Mediated Immune Evasion in Glioblastoma via BRCC3-Dependent IGF2BP2 Stabilization Rongqing Li, Jiahui Wang, Xiangrui Meng, Jiahua Pan, Xin Chen, Xin Pan, Wei Li, Shigang Qiao, Li Qian Int. J. Biol. Sci. 2026; 22(14): 7557-7584. doi:10.7150/ijbs.134558 Full text PDF

The Microbial Metabolite IDA Sensitizes Tumor Cells to ARF1 Inhibition by Inducing SVIL-dependent Senescence Menglin Huang, Xuan Wang, Yanfeng Jiang, Jincheng Li, Binliu Hu, Yuetong Wang, Steven X. Hou Int. J. Biol. Sci. 2026; 22(14): 7585-7605. doi:10.7150/ijbs.133716 Full text PDF

Anlotinib enhances the sensitivity to docetaxel in lung cancer through inhibiting DDR1-mediated glycolytic pathway Xueqin Chen, Juan Shen, Zhifei Xu, Bo Xu, Jie Huang, Jingjing Jiang, Yidan Chen, Xin Li, Shaoyu Yang, Kan Wu, Jiaoli Wang, Peihua Luo, Qiaojun He, Shenglin Ma, Bing Xia, Bo Yang Int. J. Biol. Sci. 2026; 22(14): 7610-7627. doi:10.7150/ijbs.129604 Full text PDF

Sex-dependent protective responses of taurine in ameliorating radiation-induced intestinal injury: gut microbiota reprogramming in males and estrogen-dependent immunity in females Xudong Ding, Jia Du, Zhaoyu Wang, Lu Lu, Saijun Fan Int. J. Biol. Sci. 2026; 22(14): 7628-7643. doi:10.7150/ijbs.137118 Full text PDF

Dysregulation of the Upb1-3-ureidopropionate Pathway Impairs Fatty Acid Metabolism and Exacerbates Acute Kidney Injury Yu Zhang, Jia He, Runxin Zeng, Mingzhu Jiang, Shuang Xu, Yuxian Guo, Yue Zhang, Zhanjun Jia, Ran You, Mengqiu Wu, Aihua Zhang, Mi Bai Int. J. Biol. Sci. 2026; 22(14): 7644-7666. doi:10.7150/ijbs.135329 Full text PDF

Targeting tubular NAT10 ameliorates the renal Tubulointerstitial Fibrosis in Obstructive and Folic Acid-Induced Nephropathy Qin Kang, Lin Yin, Chenkai Wu, Wende Yan, Sai Peng, Jinfang Lu, Dongshan Zhang Int. J. Biol. Sci. 2026; 22(14): 7667-7685. doi:10.7150/ijbs.135844 Full text PDF

CAF-derived BHB modulates FXR1-Kbhb and NK-cell lipid metabolism in osteosarcoma Yihan Yu, Wei Wu, Anzhen Ju, Lei Zhao, Guohui Liang, Yun Liu, Zengwu Shao, Feifei Pu, Binlong Zhong, Fengxia Chen, Jianxiang Liu, Zhicai Zhang Int. J. Biol. Sci. 2026; 22(14): 7714-7736. doi:10.7150/ijbs.128764 Full text PDF

Tubular NAT10 Promotes the Secretion of TGF-β and Lactate to Drive Fibroblast Activation in Diabetic Kidney Disease Jinfang Lu, Yuqing Feng, Xujun Peng, Zijin He, Zhou Li, Ao Jia, Yaohui Bao, Lingui Xie, Renchun Wang, Wenbo Zhang, Qin Kang, Yanyan Zhou, Cheng Wang, Hongquan Peng, Huiling Li, Dongshan Zhang Int. J. Biol. Sci. 2026; 22(14): 7737-7759. doi:10.7150/ijbs.140281 Full text PDF

Functional Genomic Screening Identifies lncRNA CNPY2-AS1 as a Regulator of Redox Metabolism and Antiviral Immunity Carolina Khoury, Tahleel Ali-Nasser, Yuval Ben Eliahu, Haya Dahamshy Silawi, Liran Ben Yaakov, Simon Rousseau, Yvan Devaux, Nisrine Lahoud-Jeries, Assaf C. Bester Int. J. Biol. Sci. 2026; 22(14): 7760-7781. doi:10.7150/ijbs.132728 Full text PDF

Hippocampal NLRP3 Inflammasome Drives Anxiety- and Depressive-Like Behaviors Following Drug-Induced Liver Injury Hao Zhang, Jia-Lu Zhuang, Rui Ma, Sheng Wang, Jing Huang, Hui-Xia Yang, Ming-Ming Hu, Xiao-Li Wei, Hai-Yuan Shen, Hui Fang, Wen-Ning Wu, Hua Wang Int. J. Biol. Sci. 2026; 22(14): 7782-7799. doi:10.7150/ijbs.128620 Full text PDF

Histone demethylase KDM4A promotes endometrial cancer progression through an ERRγ-associated cell-cycle regulatory axis Junfeng Chen, Xiaoli Wen, Donghai Zhang, Mengyue Zhu, Hong Zhou, Yiran Li, Xiaoping Wan Int. J. Biol. Sci. 2026; 22(14): 7827-7844. doi:10.7150/ijbs.133986 Full text PDF

Glycolytic Reprogramming Mediated by the OTUD4-FXR1-HIF1A Axis Drives Gastric Cancer Progression Fulin Wang, Yu Shao, Xiaomei Zhuang, Xiumin Liu, Yu Hu, Chen Dai, Jia Chen, Yong Kuang, Gangqiang Wang, Zhenzhen Zhao, Nan Cai, Liang Gu, Guoying Zhou, Hongwu Chu, Huimin Zhao, Cuncan Deng, Changhua Zhang Int. J. Biol. Sci. 2026; 22(14): 7845-7861. doi:10.7150/ijbs.138384 Full text PDF

Integrated single-cell TCR analysis across tissue identifies GZMK⁺CD8⁺ T cells promoting fibrosis via TGF-β signalling in IPF Bingqing Yue, Shuliang Jing, Qiaxuan Li, Guoyu Xie, Juan Chen, Tao Yan, Ganggui Zhu, Bin Huang, Jin Zhao, Xiucheng Yang, Jian Huang, Pan Yin, Qifeng Yao, Huijing Yang, Fei Gao, Jun Yang, Man Huang, Jingyu Chen Int. J. Biol. Sci. 2026; 22(14): 7862-7886. doi:10.7150/ijbs.134974 Full text PDF

Ezrin Functions as a Key Mechanosensitive Effector to Preserve Cell Structure and Promote Survival and Metastasis of Lung Cancer Cells during Circulation Xiaoying Zhang, Muya Zhou, Koukou Li, Mingheng Yuan, Haibo Tong, Kathy Qian Luo Int. J. Biol. Sci. 2026; 22(14): 7887-7907. doi:10.7150/ijbs.127134 Full text PDF

Genomic and Transcriptomic Landscapes of MEN1-Wild-Type Low-Grade Metastatic Pancreatic NETs Uncover Key Oncogenic Drivers and Targetable Pathways Md. Hafiz Uddin, Zaid Mahdi, Irfana Muqbil, Brendon R. Herring, Bart Rose, Husain Y. Khan, Yiwei Li, Amro Aboukameel, Sahar F. Bannoura, Hugo Jimenez, Allan M. Johansen, Mohammad Najeeb Al-Hallak, Ibrahim Azar, Amr Mohamed, Tarik Hadid, Nitin Vaishampayan, Yang Shi, Yin Wan, Vy Ong, Gregory Dyson, Rafic Beydoun, Miguel Tobon, Eliza W. Beal, Herbert Chen, Anthony F. Shields, Philip A. Philip, Jennifer Beebe-Dimmer, Ramzi M. Mohammad, Boris C. Pasche, Bassel F. El-Rayes, Asfar S. Azmi Int. J. Biol. Sci. 2026; 22(14): 7908-7927. doi:10.7150/ijbs.134269 Full text PDF

Targeting Iron Regulatory Protein 2 in Tumor-associated Macrophages Activates Antitumor Immunity in NSCLC via Modulating SphK1-PD-L1 Axis Jiawen Ding, Qinpei Cheng, Chen Cheng, Ying Mei, Liu Yang, Peilin Chen, Lei Zheng, Suhua Zhu, Kaikai Shen, Kuanyu Li, Tangfeng Lv Int. J. Biol. Sci. 2026; 22(14): 7928-7947. doi:10.7150/ijbs.130591 Full text PDF

Human-Mouse Chimerism for Organogenesis Without Neural or Germline Contributions Sen Ye, Kailibinuer Kadier, Ye Yi, Guihui Qin, Borong Huang, Siyi Fu, Cantas Alev, Ren-He Xu Int. J. Biol. Sci. 2026; 22(14): 7948-7962. doi:10.7150/ijbs.119609 Full text PDF

Reviews

Decoding Vascular Senescence: Cellular Insights and Therapeutic Strategies Mengyuan Gao, Chongjin Zhong, Jiajia Shen, Sainan Peng, Xue Zhou, Qiuhong Shen, Cheng Qian, Xinming Yang, Yuxuan Gong, Kang Zhang, Yin Lu, Xiaodong Shu, Yang Zhao Int. J. Biol. Sci. 2026; 22(14): 7686-7713. doi:10.7150/ijbs.133661 Full text PDF

Bioactive Constituents of Ginseng in Cancer Therapy: Molecular Mechanisms, Translational Potential, and Advanced Delivery Strategies Jia-hui Li, Yan-fang Xian, De-wen Liu, Hong-yuan Li, Wei Li Int. J. Biol. Sci. 2026; 22(14): 7800-7826. doi:10.7150/ijbs.136955 Full text PDF

Protein Post-Translational Modifications in the Regulation of Ferroptosis: New Opportunities and Challenges for Cancer Immunotherapy Xin Xie, Lizhou Song, Zhaoyu Li, Jiahao Hu, Zhiheng Lin, Yadong Guo, Haoling Zhang, Wangzheqi Zhang, Zui Zou Int. J. Biol. Sci. 2026; 22(14): 7963-8007. doi:10.7150/ijbs.135689 Full text PDF

Commentary

Regenerative extracellular vesicles reshape systemic aging: lessons from antler stem cells Seung-Jae Lee, Jaehoon Bae, Ye Ji Cheon, Eun-Kyung Kim Int. J. Biol. Sci. 2026; 22(14): 7606-7609. doi:10.7150/ijbs.140033 Full text PDF