Volume 23, Issue 1

Volume 23 (1); 2027

Research Papers

An RGD-Dependent ROBO1-Integrin αvβ1 Axis Promotes Liver Fibrosis in Metabolic Dysfunction-Associated Steatohepatitis Tian Tian, Martin Nzegwu, Alexander Mrozek, Yuhua Xue, Chunbao Sun, Arina Zhirkova, Mahfuza Mannan, Rineetha Tandra, Hua Lu, Heewon Park, Liya Pi Int. J. Biol. Sci. 2027; 23(1): 1-18. doi:10.7150/ijbs.125549 Full text PDF

Mitochondria-encoded circRNA mecciRNR2 promotes hepatocellular carcinoma progression by stabilizing HNRNPA1 and suppressing IGFBP3 expression Juzheng Sui, Jingxin Li, Kang Xie, Liang Shi, Ge Shan, Xu Liu Int. J. Biol. Sci. 2027; 23(1): 19-41. doi:10.7150/ijbs.133788 Full text PDF

Targeting PYCR2-PP2Ac-eIF2α Axis Enhances the Efficacy of KRAS^G12D Inhibition in Cholangiocarcinoma Huibo Feng, Mengmiao Pei, Mengyou Xu, Xinhao Xing, Zhongning Yu, Xinzhu Quan, Lu Chen, Yunkai Lin, Yufei Pan, Taiyu Shang, Yuanyuan Zhang, Liwei Dong, Tianyi Jiang, Hongyang Wang Int. J. Biol. Sci. 2027; 23(1): 42-58. doi:10.7150/ijbs.136334 Full text PDF

TRPP2 Drives Anti-PD-1 Resistance in Head and Neck Cancer by Stabilizing PD-L1 and Promoting Its Exosomal Export Ziqi Meng, Xu Huang, Jinjie Wang, Jiyuan Shi, Yuxin Zhang, Suwen Bai, Xinyue Zhang, Minghua Wang, Zhenye Yang, Xiaoqiang Yao, Xu Ji, Juan Du Int. J. Biol. Sci. 2027; 23(1): 59-76. doi:10.7150/ijbs.136182 Full text PDF

FAT1 Promotes EGFR-TKI Resistance in Non-Small Cell Lung Cancer Cells by Inducing Mitophagy Chen Ding, Hua Huang, Zexia Zhao, Wenhao Zhao, Xuanguang Li, Hongbing Zhang, Minghui Liu, Chen Chen, Yongwen Li, Hongyu Liu, Jun Chen Int. J. Biol. Sci. 2027; 23(1): 99-118. doi:10.7150/ijbs.139485 Full text PDF

Functional Genomic Screening Identifies FOXP1 as a Tumor-Intrinsic Mediator of Immune Evasion in Pancreatic Cancer Bao Yingying, Li Yini, Zhao Yang, Li Ting, Huang Junming, Yang Ze, Li Xiangyang, Yang Yixiao, Zhao Shijun, Lin Jian, Li Shuaifeng Int. J. Biol. Sci. 2027; 23(1): 119-136. doi:10.7150/ijbs.135841 Full text PDF

Dual Targeting of the FOXM1-ELF3 Reciprocal Transcriptional Circuit as a Promising Therapeutic Strategy for Refractory NSCLC Jeon-Soo Lee, Young Eun Choi, Jungho Kim, Yongdoo Choi, Sung-Ho Goh Int. J. Biol. Sci. 2027; 23(1): 137-159. doi:10.7150/ijbs.138349 Full text PDF

Single-cell RNA-seq Combined with Spatial Transcriptomics Reveals Intrinsic Drug Resistance Mechanisms Associated with SENP6-Regulated AR SUMOylation in Prostate Cancer Xin'an Wang, Chang Lu, Hanchu Ye, Chengdang Xu, Wei Wu, Yicong Yao, Wei Jiang, Qiang Wu, Denglong Wu, Licheng Wang Int. J. Biol. Sci. 2027; 23(1): 160-181. doi:10.7150/ijbs.130088 Full text PDF

tRNA-Derived Fragment tRF-1^ArgACG Drives HCC Osteolytic Bone Metastasis via ALKBH5-Mediated INPP4B Destabilization and PI3K/AKT Activation Jinyan Feng, Long Chen, Xianfu Wei, Houzhi Yang, Xiuxin Han, Qingqian Zhao, Qian Li, Xin Chen, Chao Zhang, Yafei Wang, Bowen Liu, Guowen Wang Int. J. Biol. Sci. 2027; 23(1): 182-206. doi:10.7150/ijbs.127457 Full text PDF

Activin A directs porcine embryonic stem cell commitment to extraembryonic endoderm lineage Hanning Wang, Liang Zhong, Xiaofeng Yan, Kaipeng Wang, Chengchen Zhao, Jinzhu Xiang, Duanqing Pei Int. J. Biol. Sci. 2027; 23(1): 255-269. doi:10.7150/ijbs.133831 Full text PDF

A CBS3-targeting direct AMPK activator ameliorates Alzheimer's disease pathology and cognitive decline Kyung-Hwa Jeon, Hyunji Jo, Soyeon Cho, Jae-Ho Shin, Seojeong Park, Kyu-Yeon Jun, Seojeong Kim, Seung Hee Seo, Soo-Yeon Hwang, Dabin Song, Yumi Son, Zhi Zheng, Hyunjeong Kim, Younghwa Na, Eosu Kim, Youngjoo Kwon Int. J. Biol. Sci. 2027; 23(1): 270-287. doi:10.7150/ijbs.138139 Full text PDF

In-Depth Interaction Proteomics Defines Global GABA_A Receptor Interactome and Reveals Novel Receptor Associated Proteins Miao Chen, Frank Koopmans, Miguel Angel Gonzalez-Lozano, August Benjamin Smit, Ka Wan Li Int. J. Biol. Sci. 2027; 23(1): 341-357. doi:10.7150/ijbs.132239 Full text PDF

Personalized Colorectal Cancer Therapy Guided by Patient-Derived Organoids for Different Gene Mutations Jinghong Chen, Jing-Bo Zhou, Fangyuan Shao, Yangyang Feng, Xiangpeng Chu, Ling Li, Kai Miao, Duo Liu, Weihao Deng, Wen-Li Zhu, Guang-Hui Luo, Kin-Iong Chan, Zheyu Cai, Jinbao Liu, Jian Cai, Chu-Xia Deng Int. J. Biol. Sci. 2027; 23(1): 358-375. doi:10.7150/ijbs.142563 Full text PDF

PNRC1 drives self-reinforcing activation of p53 in colorectal cancer Chen Xiong, Qinghua Zhang, Tengfei Chao, Bangxiang Xie, Jing Tong, Yu Gan, Ruiwen Ruan, Jun Deng, Jianchun Chen, Tao Han, Xiang Zhou, Chunmeng Wang, Qian Hao Int. J. Biol. Sci. 2027; 23(1): 376-390. doi:10.7150/ijbs.138648 Full text PDF

Eupalinolide B induces ferroptosis in activated HSCs to attenuate hepatic fibrosis via targeting peroxiredoxin 1 Yin-Kwan Wong, Qian Zhang, Min Zou, Yu Chen, Weiyi He, Yehai An, Dandan Liu, Ting Cao, Xiaoqin He, Juyi Tian, Qiwei Zhang, Yao Liang, Xuan Xiong, Xiaoyong Zhang, Wei Xiao, Jigang Wang, Ye Chen, Piao Luo Int. J. Biol. Sci. 2027; 23(1): 391-406. doi:10.7150/ijbs.136441 Full text PDF

The Foxo4/Tcf12/TGF-β signaling pathway promotes senescence and fibrosis after cisplatin nephrotoxicity Fang Xu, Honglin Li, Yu Xiang, Yuqing Zeng, Yun Han, Wenwen Wu, Ying Fu, Juan Cai, Fanghua Li, Dongshan Zhang, Yu Liu, Zheng Dong Int. J. Biol. Sci. 2027; 23(1): 427-443. doi:10.7150/ijbs.139696 Full text PDF

Morc4 suppresses breast cancer lung metastasis by restricting Tslp-driven Naïve T cell accumulation Xin Zhang, Min Deng, Sek Man Su, Yuqing Wang, Haipeng Lei, Tingting An, Jianjie Li, Jun Xu, Kai Miao, Xiaoling Xu Int. J. Biol. Sci. 2027; 23(1): 444-461. doi:10.7150/ijbs.142712 Full text PDF

Biochemical and Immunological Properties of Engineered Low-Immunogenic Staphylokinases for Next-Generation Thrombolytic Therapy Alan Strunga, Michaela Peskova, Michal Krupka, Katerina Zachova, Lenka Sindlerova, Nikola Neumeisterova, Jan Mican, Jan Vitecek, David Bednar, Stanislav Mazurenko, Lukas Kubala, Milan Raska, Jiri Damborsky, Zbynek Prokop Int. J. Biol. Sci. 2027; 23(1): 489-506. doi:10.7150/ijbs.138723 Full text PDF

Reviews

The Crucial Roles of the Lysine Acetyltransferases KAT6A and KAT6B in Development and Neurodevelopmental Disorders Naama Wiesel-Motiuk, Yehuda G. Assaraf Int. J. Biol. Sci. 2027; 23(1): 77-98. doi:10.7150/ijbs.140131 Full text PDF

Emerging roles of deep learning in cancer diagnosis, therapy, and risk prediction Shuiqing Liu, Xingyu Wan, Nan Li, Wuchen Yang, Jingya Liu, Shengwang Wu, Jing Zhang, Dezhi Huang, Yang Gou, Ping Wang, Tinglu Tao, Hao Wang, Siyin Chen, Yongjie Tang, Cheng Yang, Cheng Zhang, Xiangui Peng, Xi Zhang Int. J. Biol. Sci. 2027; 23(1): 207-254. doi:10.7150/ijbs.130783 Full text PDF

Extracellular Vesicle Heterogeneity in Colorectal Cancer: From Biological Diversity to Therapeutic Translation and Precision Intervention Yining Sun, Xian Zhang, Feifan Chen, Binyang Luo, JinLin Yang, Zhu Wang Int. J. Biol. Sci. 2027; 23(1): 288-320. doi:10.7150/ijbs.140085 Full text PDF

Vascularization of Endometrial Organoids: From Basic Biology to Clinical Translation in Reproductive Medicine Dan Mo, Zhonghong Zeng, Dezhi Mao, Jiayi Ma, Haiyan Huang, Jizhou Li, Xi Cheng, Yandong Chen, Yueqi Leng, Mengqing Gu, Yang Yu, Xunsi Qin, Rong Li Int. J. Biol. Sci. 2027; 23(1): 321-340. doi:10.7150/ijbs.134435 Full text PDF

Metabolic Syndrome-Associated Osteoarthritis: Linking Systemic Metabolic Dysregulation to Disease Pathogenesis and Therapeutic Perspectives Xinyu Zhang, Guangyu Ding, Bowei Ni, Liyuan Jia, Liu Yang Int. J. Biol. Sci. 2027; 23(1): 407-426. doi:10.7150/ijbs.130487 Full text PDF

Advances in T Cell - B Cell Interaction Networks in Idiopathic Membranous Nephropathy: From Immunological Mechanisms to Precision Therapeutics Lin Wang, Qin Tian, Ao Xu, Lianli Shen, Yue Xing, Tianxingjian Ke, Yuling Liang, Jinjie Gao, Hongtao Yang, Jinxiang Wang, Yifei Zhong Int. J. Biol. Sci. 2027; 23(1): 462-488. doi:10.7150/ijbs.131542 Full text PDF