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Volume 22 (13); 2026

Research Papers

Novel Phosphatase SSU72 Drives Malignant Progression in Colorectal Cancer via PERK^Thr982 Dephosphorylation Mediated Endoplasmic Reticulum Stress Inactivation Dongming Liu, Yuchao He, Wenshuai Chen, Zhonghao Sun, Wenchen Gong, Yu Wang, Jiaqi Ni, Yi Luo, Liwei Chen, Changfu Liu, Hua Li, Hua Guo Int. J. Biol. Sci. 2026; 22(13): 6876-6891. doi:10.7150/ijbs.129555 Full text PDF

Targeting Mitochondrial PD-L1 O-GlcNAcylation to Sensitize HBV-Related HCC to Immunotherapy: Modulating Golgi-mitochondrial Crosstalk and mTOR/PGC-1α-Driven Mitochondrial Biogenesis to Overcome Resistance Ze-Bang Du, Xin-Yu Ma, Han-Yu Zhang, Jia-Ming Lei, Xin-Xin He, Wen-Qi Xu, Wen-Dan Zhou, Xiao-Gang Xia, Ao-Bo Zhuang, Xiao-Xuan Chen, You-Liang Yao, Wen-Gang Li, Yu-Chun Lin, Zhong-Ning Lin Int. J. Biol. Sci. 2026; 22(13): 6892-6913. doi:10.7150/ijbs.126948 Full text PDF

DHA Targets RAB1B to Mediate the Driving Force Transmission of Copper Ion Vesicular Endocytosis Under Copper Overload for Promoting Cuproptosis and Ferroptosis in Hepatic Stellate Cells Xinran Qiu, Haoyuan Tian, Shujiang Sun, Ningyu Qiu, Biao Xu, Junrui Wang, Yuanyuan Gao, Zhengyang Bao, Xiang Han, Jie Zeng, Yuxin Lin, Feng Zhang, Shizhong Zheng, Jiangjuan Shao Int. J. Biol. Sci. 2026; 22(13): 6914-6944. doi:10.7150/ijbs.134520 Full text PDF

Interleukin-39 aggravates sepsis by inducing self-sustaining neutrophil activation in the lungs via the CXCL1-CXCR2 pathway Jinming Zhang, Jingting Liu, Yihui Wang, Yifan Xu, Robim M Rodrigues, Zihan Zhou, Jie Lu, Ziqiang Li, Xiaolin Wang, Jingjiao Li, Yong He, Fouad Lafdil, Ruidong Mo, Enqiang Mao, Qing Xie, Xiaogang Xiang Int. J. Biol. Sci. 2026; 22(13): 6945-6968. doi:10.7150/ijbs.124607 Full text PDF

Enhanced WWP2 Exacerbates Podocyte Injury in Lupus Nephritis through Monoubiquitylating H2A at K119 Ran You, Yuteng Jiang, Yingyi Xu, Qianying Liu, Menglei Gu, Yue Zhang, Zhanjun Jia, Mengqiu Wu, Mi Bai, Aihua Zhang Int. J. Biol. Sci. 2026; 22(13): 6969-6984. doi:10.7150/ijbs.131475 Full text PDF

Review

CAR T Cell Therapy in Lung Cancer: Overcoming Tumor Microenvironment-Mediated Barriers Lu Liu, Dandan Liang, Cui Wang, Jian Li, Jie Tang, Weimin Li, Xijie Yu Int. J. Biol. Sci. 2026; 22(13): 6985-7002. doi:10.7150/ijbs.131261 Full text PDF

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