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Int J Biol Sci 2011; 7(9):1239-1256. doi:10.7150/ijbs.7.1239 This issue Cite

Review

Macrophage Migration Inhibitory Factor (MIF): A Key Player in Protozoan Infections

Juan de Dios Rosado, Miriam Rodriguez-Sosa✉

Unidad de Biomedicina, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México (UNAM), 54090 Tlalnepantla, Estado de México, México.

✉ Corresponding author: Miriam Rodriguez-Sosa, Unidad de Biomedicina, FES-Iztacala, UNAM. Av. de los Barrios # 1, Los Reyes Iztacala, 54090 Tlalnepantla, Edo. de México. Mexico. Phone: (52-55) 5623-1333 ext. 39789. Fax: (52-55) 5623-1138. Email: More

Citation:
de Dios Rosado J, Rodriguez-Sosa M. Macrophage Migration Inhibitory Factor (MIF): A Key Player in Protozoan Infections. Int J Biol Sci 2011; 7(9):1239-1256. doi:10.7150/ijbs.7.1239. https://www.ijbs.com/v07p1239.htm
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Abstract

Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine produced by the pituitary gland and multiple cell types, including macrophages (Mø), dendritic cells (DC) and T-cells. Upon releases MIF modulates the expression of several inflammatory molecules, such as TNF-α, nitric oxide and cyclooxygenase 2 (COX-2). These important MIF characteristics have prompted investigators to study its role in parasite infections. Several reports have demonstrated that MIF plays either a protective or deleterious role in the immune response to different pathogens. Here, we review the role of MIF in the host defense response to some important protozoan infections.

Keywords: Macrophage migration inhibitory factor, Protozoan infections, Inflammatory response, Control of parasite infections, innate immune response.

Citation styles

APA
de Dios Rosado, J., Rodriguez-Sosa, M. (2011). Macrophage Migration Inhibitory Factor (MIF): A Key Player in Protozoan Infections. International Journal of Biological Sciences, 7(9), 1239-1256. https://doi.org/10.7150/ijbs.7.1239.

ACS
de Dios Rosado, J.; Rodriguez-Sosa, M. Macrophage Migration Inhibitory Factor (MIF): A Key Player in Protozoan Infections. Int. J. Biol. Sci. 2011, 7 (9), 1239-1256. DOI: 10.7150/ijbs.7.1239.

NLM
de Dios Rosado J, Rodriguez-Sosa M. Macrophage Migration Inhibitory Factor (MIF): A Key Player in Protozoan Infections. Int J Biol Sci 2011; 7(9):1239-1256. doi:10.7150/ijbs.7.1239. https://www.ijbs.com/v07p1239.htm

CSE
de Dios Rosado J, Rodriguez-Sosa M. 2011. Macrophage Migration Inhibitory Factor (MIF): A Key Player in Protozoan Infections. Int J Biol Sci. 7(9):1239-1256.

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