1. State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou 510006, China; 2. Laboratory of Animal Fat Deposition and Muscle Development, College of Animal Science and Technology, Northwest A&F University, Yangling, China.
✉ Corresponding author: Delin Mo. Address: State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou 510006, China. Email: modelinsysu.edu.cn; Tel: (86) 20-39332991; Fax: (86) 20-39332940.
Citation:
Wu M, Yang G, Chen Y, Zhou X, Chen H, Li M, Yu K, Zhang X, Xie S, Zhang Y, Chu G, Mo D. CEP2 Attenuates Myoblast Differentiation But Does Not Affect Proliferation. Int J Biol Sci 2015; 11(1):99-108. doi:10.7150/ijbs.8621. https://www.ijbs.com/v11p0099.htm
CEP2 (CDC42EP2) is a member of the CDC42 subfamily that belongs to the Rho family. The Rho family plays an important role in a variety of cellular processes including skeletal myogenesis. Here, we find the expression of CEP2 increased significantly during C2C12 myogenesis. Overexpression of CEP2 could attenuate myoblast differentiation, while knockdown of CEP2 by siRNA results in enhancing myogenesis. Furthermore, we demonstrate for the first time that CEP2 attenuates myoblast differentiation via suppression of muscle regulatory factors (MRFs) rather than influencing myoblast proliferation. These results indicate that CEP2 acts as a repressor during myogenesis, which provides new insights into the role of CEP2 in muscle development.
Wu, M., Yang, G., Chen, Y., Zhou, X., Chen, H., Li, M., Yu, K., Zhang, X., Xie, S., Zhang, Y., Chu, G., Mo, D. (2015). CEP2 Attenuates Myoblast Differentiation But Does Not Affect Proliferation. International Journal of Biological Sciences, 11(1), 99-108. https://doi.org/10.7150/ijbs.8621.
ACS
Wu, M.; Yang, G.; Chen, Y.; Zhou, X.; Chen, H.; Li, M.; Yu, K.; Zhang, X.; Xie, S.; Zhang, Y.; Chu, G.; Mo, D. CEP2 Attenuates Myoblast Differentiation But Does Not Affect Proliferation. Int. J. Biol. Sci. 2015, 11 (1), 99-108. DOI: 10.7150/ijbs.8621.
NLM
Wu M, Yang G, Chen Y, Zhou X, Chen H, Li M, Yu K, Zhang X, Xie S, Zhang Y, Chu G, Mo D. CEP2 Attenuates Myoblast Differentiation But Does Not Affect Proliferation. Int J Biol Sci 2015; 11(1):99-108. doi:10.7150/ijbs.8621. https://www.ijbs.com/v11p0099.htm
CSE
Wu M, Yang G, Chen Y, Zhou X, Chen H, Li M, Yu K, Zhang X, Xie S, Zhang Y, Chu G, Mo D. 2015. CEP2 Attenuates Myoblast Differentiation But Does Not Affect Proliferation. Int J Biol Sci. 11(1):99-108.
Global reach, higher impact
