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Int J Biol Sci 2018; 14(12):1636-1644. doi:10.7150/ijbs.28089 This issue Cite

Review

Role of canonical Hedgehog signaling pathway in liver

Lili Gao^1*, Zhenya Zhang^2*, Peng Zhang¹, Minghua Yu^3✉, Tao Yang^1✉

1. Center for Medical Research and Innovation, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, 201399, China
2. Department of general surgery, Hebei Medical University Fourth Hospital, Shijiazhuang, 050011, China
3. Department of Oncology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai 201399, China
*These two authors contributed equally to this work.

✉ Corresponding authors: Dr. Minghua Yu, Department of Oncology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai 201399, China. Phone: 86-21-68030812; E-mail: ymh3011com and Dr. Tao Yang, Center for Medical Research and Innovation, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, 2800 Gongwei Road, Shanghai 201399, China. Phone: 86-21-68036516; E-mail: taoyangedu.cn More

Abstract

Hedgehog (Hh) signaling pathway plays an important role in embryonic development. It becomes reactivated in many types of acute and chronic liver injuries. Hh signaling is required for liver regeneration, regulates capillarisation, controls the fates of hepatic stellate cells, promotes liver fibrosis and liver cancers. In this review, we summarize the current knowledge of the role of canonical Hh signaling pathway in adult liver. This help to understand the pathogenesis of liver diseases and find out the new effective targeted therapeutic strategies for liver diseases treatments.

Keywords: Hedgehog, liver, fibrosis, HCC

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