Int J Biol Sci 2019; 15(12):2576-2583. doi:10.7150/ijbs.33733

Review

Research Advances in CKLF-like MARVEL Transmembrane Domain-containing Family in Non-small Cell Lung Cancer

Keheng Wu1#, Xiaoman Li2#, Huadi Gu3, Qiao Yang1, Yingying Liu1, Liang Wang3✉

1. China Medical University-The Queen's University of Belfast Joint College, Shenyang, Liaoning, 110122, China
2. Institute of Translational Medicine, Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang, Liaoning, 110122, China
3. Department of Pathology, College of Basic Medical Sciences, China Medical University, Liaoning, 110122, China
#: These authors contributed equally to this study.

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Citation:
Wu K, Li X, Gu H, Yang Q, Liu Y, Wang L. Research Advances in CKLF-like MARVEL Transmembrane Domain-containing Family in Non-small Cell Lung Cancer. Int J Biol Sci 2019; 15(12):2576-2583. doi:10.7150/ijbs.33733. Available from http://www.ijbs.com/v15p2576.htm

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Abstract

CKLF-like MARVEL transmembrane domain-containing member (CMTM) is a new gene family first cloned and reported in 2001. The CMTM family consists of nine members including CKLF and CMTM1-CMTM8, which are located on different chromosomes. Besides exhibiting extensive chemotactic activity, the CMTM family plays an important role in the hematopoiesis system, the immune system, the cardiovascular system and the male reproductive system. Recent in-depth research has also revealed that CMTM is closely associated with the genesis, development and metastasis of tumors, displaying opposing activities in diverse human tumors. In this review, we discuss the structural and functional characteristics of the CMTM family and summarize latest research findings of the relationship between several CMTM members and non-small cell lung cancer.

Keywords: CMTM, CKLFSF, MARVEL, tumor suppressor gene, non-small cell lung cancer