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Volume 18 (16); 2022

Research Papers

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Tumor-associated macrophages in direct contact with prostate cancer cells promote malignant proliferation and metastasis through NOTCH1 pathway
Fei Shi, Meng-Hao Sun, Zheng Zhou, Lei Wu, Zheng Zhu, Shu-Jie Xia, Bang-Min Han, Yu-Yang Zhao, Yi-Feng Jing, Di Cui
Int. J. Biol. Sci. 2022; 18(16): 5994-6007. doi:10.7150/ijbs.73141
[Abstract] [Full text] [PDF]


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Endocytosis of Peptidase Inhibitor SerpinE2 promotes Myocardial Fibrosis through activating ERK1/2 and β-catenin Signaling Pathways
Chao Li, Li-fang Lv, Mu-ge Qi-Li, Rui Yang, Yu-jing Wang, Shuang-shuang Chen, Ming-xiu Zhang, Tian-yu Li, Tong Yu, Yu-hong Zhou, Hai-hai Liang, Hong-li Shan, Xue-lian Li
Int. J. Biol. Sci. 2022; 18(16): 6008-6019. doi:10.7150/ijbs.67726
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Downregulation of SEPTIN5 inhibits prostate cancer progression by increasing CD8+ T cell infiltration
Ming Chang, Yu He, Cong Liu, Risheng Lin, Xin Huang, Dongcuan Liang, Jian Zhang, Yi Lu
Int. J. Biol. Sci. 2022; 18(16): 6035-6051. doi:10.7150/ijbs.76573
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Intermittent Fasting Attenuates Hallmark Vascular and Neuronal Pathologies in a Mouse Model of Vascular Cognitive Impairment
Vismitha Rajeev, David Y. Fann, Quynh Nhu Dinh, Hyun Ah Kim, T. Michael De Silva, Dong-Gyu Jo, Grant R. Drummond, Christopher G. Sobey, Mitchell K.P. Lai, Christopher Li-Hsian Chen, Thiruma V. Arumugam
Int. J. Biol. Sci. 2022; 18(16): 6052-6067. doi:10.7150/ijbs.75188
[Abstract] [Full text] [PDF]


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GALNT1 Enhances Malignant Phenotype of Gastric Cancer via Modulating CD44 Glycosylation to Activate the Wnt/β-catenin Signaling Pathway
Junchang Zhang, Han Wang, Jing Wu, Cheng Yuan, Songyao Chen, Shuhao Liu, Mingyu Huo, Changhua Zhang, Yulong He
Int. J. Biol. Sci. 2022; 18(16): 6068-6083. doi:10.7150/ijbs.73431
[Abstract] [Full text] [PDF]


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HNRNPK/CLCN3 axis facilitates the progression of LUAD through CAF-tumor interaction
Yixin Li, Yang Yang, Qian Ma, Huifang Cheng, Hui Wang, Chao Ma, Feng Li, Song Zhao, Xiangnan Li, Yu Qi, Zhuoyu Gu
Int. J. Biol. Sci. 2022; 18(16): 6084-6101. doi:10.7150/ijbs.76083
[Abstract] [Full text] [PDF]


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Reversion of glucocorticoid-induced senescence and collagen synthesis decrease by LY294002 is mediated through p38 in skin
Quoc-Vu Le, Su-Ying Wen, Chih-Jung Chen, Chih-Yang Huang, Wei-Wen Kuo
Int. J. Biol. Sci. 2022; 18(16): 6102-6113. doi:10.7150/ijbs.73915
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Stearoyl-CoA Desaturase-1 dependent lipid droplets accumulation in cancer-associated fibroblasts facilitates the progression of lung cancer
Yana Zhang, Zhuoyu Gu, Jiajia Wan, Xiaohan Lou, Shuangqing Liu, Yuan Wang, Yangyang Bian, Fei Wang, Zhenzhen Li, Zhihai Qin
Int. J. Biol. Sci. 2022; 18(16): 6114-6128. doi:10.7150/ijbs.74924
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Down-regulation of BMAL1 by MiR-494-3p Promotes Hepatocellular Carcinoma Growth and Metastasis by Increasing GPAM-mediated Lipid Biosynthesis
Yi Yang, Tao Yang, Zifeng Zhao, Hongxin Zhang, Peng Yuan, Gang Wang, Zheng Zhao, Jiaze An, Zhuomin Lyu, Jinliang Xing, Jibin Li
Int. J. Biol. Sci. 2022; 18(16): 6129-6144. doi:10.7150/ijbs.74951
[Abstract] [Full text] [PDF]


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ELK1-mediated YTHDF1 drives prostate cancer progression by facilitating the translation of Polo-like kinase 1 in an m6A dependent manner
Peizhang Li, Yuanping Shi, Dajun Gao, Huan Xu, Yun Zou, Zhong Wang, Wenzhi Li
Int. J. Biol. Sci. 2022; 18(16): 6145-6162. doi:10.7150/ijbs.75063
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Identification of the mitochondrial protein ADCK2 as a therapeutic oncotarget of NSCLC
Jin-zhi Zhang, Jia Liu, Yi-xin Xu, Wang-yang Pu, Ming-jing Shen, Kan-qiu Jiang, Yi-ling Yang, Jingjing Lu, Zhengbo Deng, Yi Yang, Wei-hua Xu
Int. J. Biol. Sci. 2022; 18(16): 6163-6175. doi:10.7150/ijbs.78354
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4-Octyl itaconate regulates immune balance by activating Nrf2 and negatively regulating PD-L1 in a mouse model of sepsis
Peng Zhang, Yaxin Wang, Wengchang Yang, Yuping Yin, Chengguo Li, Xianxiong Ma, Liang Shi, Ruidong Li, Kaixiong Tao
Int. J. Biol. Sci. 2022; 18(16): 6189-6209. doi:10.7150/ijbs.74456
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Lactylation of PKM2 Suppresses Inflammatory Metabolic Adaptation in Pro-inflammatory Macrophages
Jizhuang Wang, Peilang Yang, Tianyi Yu, Min Gao, Dan Liu, Jie Zhang, Chenghao Lu, Xuelian Chen, Xiong Zhang, Yan Liu
Int. J. Biol. Sci. 2022; 18(16): 6210-6225. doi:10.7150/ijbs.75434
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Reviews

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Adding fuel to the fire: The lipid droplet and its associated proteins in cancer progression
Wenqin Luo, Huan Wang, Liangliang Ren, Zeyi Lu, Qiming Zheng, Lifeng Ding, Haiyun Xie, Ruyue Wang, Chenhao Yu, Yudong Lin, Zhenwei Zhou, Liqun Xia, Gonghui Li
Int. J. Biol. Sci. 2022; 18(16): 6020-6034. doi:10.7150/ijbs.74902
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Lipid Droplets: A Cellular Organelle Vital for Thermogenesis
Lupeng Chen, Yi Jin, Jian Wu, Zhuqing Ren
Int. J. Biol. Sci. 2022; 18(16): 6176-6188. doi:10.7150/ijbs.77051
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Errata

MUC3A promotes non-small cell lung cancer progression via activating the NFκB pathway and attenuates radiosensitivity
Yingming Sun, Xiaoge Sun, Chengcheng You, Shijing Ma, Yuan Luo, Shan Peng, Fang Tang, Xiaoli Tian, Feng Wang, Zhengrong Huang, Hongnv Yu, Yu Xiao, Xiaoyong Wang, Junhong Zhang, Yan Gong, Conghua Xie
Int. J. Biol. Sci. 2022; 18(16): 6226. doi:10.7150/ijbs.79140
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Identification and Characterization of Alcohol-related Hepatocellular Carcinoma Prognostic Subtypes based on an Integrative N6-methyladenosine methylation Model: Erratum
Yue Zhang, Fanhong Zeng, Min Zeng, Xu Han, Lei Cai, Jiajun Zhang, Jun Weng, Yi Gao
Int. J. Biol. Sci. 2022; 18(16): 6227-6228. doi:10.7150/ijbs.79940
[Abstract] [Full text] [PDF]


IRF7 inhibits the Warburg effect via transcriptional suppression of PKM2 in osteosarcoma: Erratum
Zhikun Li, Mei Geng, Xiaojian Ye, Yunhan Ji, Yifan Li, Xiangyang Zhang, Wei Xu
Int. J. Biol. Sci. 2022; 18(16): 6229-6230. doi:10.7150/ijbs.79598
[Abstract] [Full text] [PDF]