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Int J Biol Sci 2023; 19(10):2974-2998. doi:10.7150/ijbs.85259 This issue Cite

Review

Cracking Brain Diseases from Gut Microbes-Mediated Metabolites for Precise Treatment

Ying Gong1,3, Anmei Chen1, Guohui Zhang2, Qing Shen3, Liang Zou4, Jiahong Li3✉, Yang-Bao Miao1✉, Weixin Liu2✉

1. Department of Haematology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine of University of Electronic Science and Technology of China, No. 32, West Section 2, First Ring Road, Qingyang District, Chengdu 610000, China
2. Key Laboratory of reproductive medicine, Sichuan Provincial maternity and Child Health Care Hospital, Chengdu 610000, China.
3. School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610041, China
4. School of Food and Biological Engineering, Chengdu University, Chengdu 610106, Sichuan, China.

✉ Corresponding authors: Yang-Bao Miao, Jiahong Li and Weixin Liu. E-mail: miaoyangbaoedu.cn, jiahongljhcom and liuweixindcom.

Citation:
Gong Y, Chen A, Zhang G, Shen Q, Zou L, Li J, Miao YB, Liu W. Cracking Brain Diseases from Gut Microbes-Mediated Metabolites for Precise Treatment. Int J Biol Sci 2023; 19(10):2974-2998. doi:10.7150/ijbs.85259. https://www.ijbs.com/v19p2974.htm
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Abstract

Graphic abstract

The gut-brain axis has been a subject of significant interest in recent years. Understanding the link between the gut and brain axis is crucial for the treatment of disorders. Here, the intricate components and unique relationship between gut microbiota-derived metabolites and the brain are explained in detail. Additionally, the association between gut microbiota-derived metabolites and the integrity of the blood-brain barrier and brain health is emphasized. Meanwhile, gut microbiota-derived metabolites with their recent applications, challenges and opportunities their pathways on different disease treatment are focus discussed. The prospective strategy of gut microbiota-derived metabolites potential applies to the brain disease treatments, such as Parkinson's disease and Alzheimer's disease, is proposed. This review provides a broad perspective on gut microbiota-derived metabolites characteristics facilitate understand the connection between gut and brain and pave the way for the development of a new medication delivery system for gut microbiota-derived metabolites.

Keywords: Gut Microbes, Metabolites, Gut to Brain, Vagus Nerve, Immune System

Citation styles

APA
Gong, Y., Chen, A., Zhang, G., Shen, Q., Zou, L., Li, J., Miao, Y.B., Liu, W. (2023). Cracking Brain Diseases from Gut Microbes-Mediated Metabolites for Precise Treatment. International Journal of Biological Sciences, 19(10), 2974-2998. https://doi.org/10.7150/ijbs.85259.

ACS
Gong, Y.; Chen, A.; Zhang, G.; Shen, Q.; Zou, L.; Li, J.; Miao, Y.B.; Liu, W. Cracking Brain Diseases from Gut Microbes-Mediated Metabolites for Precise Treatment. Int. J. Biol. Sci. 2023, 19 (10), 2974-2998. DOI: 10.7150/ijbs.85259.

NLM
Gong Y, Chen A, Zhang G, Shen Q, Zou L, Li J, Miao YB, Liu W. Cracking Brain Diseases from Gut Microbes-Mediated Metabolites for Precise Treatment. Int J Biol Sci 2023; 19(10):2974-2998. doi:10.7150/ijbs.85259. https://www.ijbs.com/v19p2974.htm

CSE
Gong Y, Chen A, Zhang G, Shen Q, Zou L, Li J, Miao YB, Liu W. 2023. Cracking Brain Diseases from Gut Microbes-Mediated Metabolites for Precise Treatment. Int J Biol Sci. 19(10):2974-2998.

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