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Volume 21 (2); 2025
Research Papers
S6K1 is a Targetable Vulnerability in Tumors Exhibiting Plasticity and Therapy Resistance Saptadwipa Ganguly, Ravshan Burikhanov, Vitaliy M. Sviripa, Sally Ellingson, Jieyun Jiang, Christian M. Gosser, David Orren, Eva M. Goellner, Gautham G. Shenoy, Mahadev Rao, John D'Orazio, Christine F. Brainson, Chang-Guo Zhan, Peter H. Spielmann, David S. Watt, Vivek M. Rangnekar
Int. J. Biol. Sci. 2025; 21(2): 454-472. doi:10.7150/ijbs.96672
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USP25 stabilizes STAT6 to promote IL-4-induced macrophage M2 polarization and fibrosis Yahan Xu, Jing Liu, Jingzeng Wang, Jiayao Wang, Peixiang Lan, Tao Wang
Int. J. Biol. Sci. 2025; 21(2): 475-489. doi:10.7150/ijbs.99345
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Caveolin-1 mitigates the advancement of metabolic dysfunction-associated steatotic liver disease by reducing endoplasmic reticulum stress and pyroptosis through the restoration of cholesterol homeostasis Hanlin Xu, Yu Li, Ning Guo, Shuai Wu, Can Liu, Zhongxuan Gui, Weiju Xue, Xiangfu Jiang, Mengjia Ye, Qianqian Geng, Xiaowen Feng, Chao Zhang, Lei Jin, Chengmu Hu
Int. J. Biol. Sci. 2025; 21(2): 490-506. doi:10.7150/ijbs.100794
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Smad2 Cooperating with TGIF2 Contributes to EMT and Cancer Stem Cells Properties in Pancreatic Cancer via Co-Targeting SOX2 Fuqiang Zu, ChuanPing Chen, Qilong Geng, Haoyu Li, Boyuan Chan, Guopei Luo, Mengcheng Wu, Matthias Ilmer, Bernhard W Renz, Lutterodt Bentum-Ennin, Hao Gu, Weiwei Sheng
Int. J. Biol. Sci. 2025; 21(2): 524-543. doi:10.7150/ijbs.102381
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TEAD1 Prevents Necroptosis and Inflammation in Cisplatin-Induced Acute Kidney Injury Through Maintaining Mitochondrial Function Melanie Tran, Baihai Jiao, Hao Du, Dong Zhou, Vijay Yechoor, Yanlin Wang
Int. J. Biol. Sci. 2025; 21(2): 565-578. doi:10.7150/ijbs.104335
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Lingo1 in the hippocampus contributes to cognitive dysfunction after anesthesia and surgery in aged mice Changliang Liu, Changteng Zhang, Ling Chen, Xin Liu, Jiahui Wu, Yalan Sun, Jin Liu, Chan Chen
Int. J. Biol. Sci. 2025; 21(2): 595-613. doi:10.7150/ijbs.98376
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HIF-2α/LPCAT1 orchestrates the reprogramming of lipid metabolism in ccRCC by modulating the FBXW7-mediated ubiquitination of ACLY Mintian Fei, Yi Zhang, Haolin Li, Qili Xu, Yu Gao, Cheng Yang, Weiyi Li, Chaozhao Liang, Baojun Wang, Haibing Xiao
Int. J. Biol. Sci. 2025; 21(2): 614-631. doi:10.7150/ijbs.103032
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TAGLN-RhoA/ROCK2-SLC2A3-mediated Mechano-metabolic Axis Promotes Skin Fibrosis Xinwei Cheng, Zhen Gao, Jin Zhang, Hongkun Zheng, Shengzhou Shan, Jia Zhou
Int. J. Biol. Sci. 2025; 21(2): 658-670. doi:10.7150/ijbs.104484
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FAT1 knockdown enhances the CSC properties of HNSCC through p-CaMKII-mediated inactivation of the IFN pathway Jingjing Wang, Yang Chen, Yunqing Sun, Hanzhe Liu, Ruixue Du, Xuewen Wang, Zhe Shao, Ke Liu, Zhengjun Shang
Int. J. Biol. Sci. 2025; 21(2): 671-684. doi:10.7150/ijbs.95723
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The Cyclin-Dependent Kinase 8 Inhibitor E966-0530-45418 Attenuates Pulmonary Fibrosis In Vitro and In Vivo Ching-Hsuan Chou, Wei-Jan Huang, Kai-Cheng Hsu, Jui-Yi Hsu, Tony Eight Lin, Chia-Ron Yang
Int. J. Biol. Sci. 2025; 21(2): 685-707. doi:10.7150/ijbs.105826
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Downregulated CCND3 Is a Key Event Driving Lung Adenocarcinoma Metastasis during Acquired Cisplatin Resistance Yun Su, Yuting Ma, Yubing Wang, Ping Xu, Miaoling Guo, Haolin Cao, Jianyang Xin, Xi Wu, Xiaoyan Liu, Shan Chen, Xingyu Tao, Huiling Yang, Chao Cheng, Rongquan Huang, Rongshuai Pan, Yuexin Pan, Beixian Zhou, Weiyi Fang, Zhen Liu
Int. J. Biol. Sci. 2025; 21(2): 708-724. doi:10.7150/ijbs.100921
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Mitochondrial SIRT2-mediated CPT2 deacetylation prevents diabetic cardiomyopathy by impeding cardiac fatty acid oxidation Yaoyao Guo, Ziyin Zhang, Zheng Wen, Xiaonan Kang, Dan Wang, Lu Zhang, Mengke Cheng, Gang Yuan, Huihui Ren
Int. J. Biol. Sci. 2025; 21(2): 725-744. doi:10.7150/ijbs.102834
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Deficiency of Epithelial PIEZO1 Alleviates Liver Steatosis Induced by High-Fat Diet in Mice Zhiyue Xu, Shu Xu, Xiaoming Liu, Lan Cheng, Xinghuang Liu, Xiaotian Xie, Dan Zhou, Dongke Wang, Jie Chen, Xiaoling Deng, Lei Zhang, Ruohang He, Ying Li, Mengmeng Cheng, Ling Yang, Xiaohua Hou, Tao Bai
Int. J. Biol. Sci. 2025; 21(2): 745-757. doi:10.7150/ijbs.102906
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FKBP10 Promotes the Muscle Invasion of Bladder Cancer via Lamin A Dysregulation Xupeng Zhao, Jichen Wang, Shuo Tian, Lu Tang, Shouqing Cao, Jiali Ye, Tianwei Cai, Yundong Xuan, Xu Zhang, Xiubin Li, Hongzhao Li
Int. J. Biol. Sci. 2025; 21(2): 758-771. doi:10.7150/ijbs.105265
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Glycine Decarboxylase Regulates Renal Carcinoma Progression via Interferon Stimulated Gene Factor 3-Mediated Pathway Thi Tuyet Mai Pham, Mikyung Kim, Thuy Quynh Nhu Nguyen, Jae-Hyung Park, Jee In Kim, Ji Hae Seo, Jin Young Kim, Eunyoung Ha
Int. J. Biol. Sci. 2025; 21(2): 772-788. doi:10.7150/ijbs.104458
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Tubulointerstitial nephritis antigen-like 1 promotes the progression of liver fibrosis after HCV eradication with direct-acting antivirals Lei Lei, Hu Li, Xue-Kai Wang, Jian-Rui Li, Han Sun, Hong-Ying Li, Jia-Yu Li, Mei Tang, Jing-Chen Xu, Biao Dong, Yue Gong, Dan-Qing Song, Jian-Dong Jiang, Zong-Gen Peng
Int. J. Biol. Sci. 2025; 21(2): 802-822. doi:10.7150/ijbs.103305
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Toll-like receptor adaptor protein TIRAP has specialized roles in signaling, metabolic control and leukocyte migration upon wounding in zebrafish larvae Li Liu, Wanbin Hu, Fatima Didar Kerman, Herman P. Spaink
Int. J. Biol. Sci. 2025; 21(2): 823-841. doi:10.7150/ijbs.101055
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BMSCs-derived small extracellular vesicles antagonize cerebral endothelial Caveolin-1 driven autophagic degradation of tight-junction proteins to protect blood-brain barrier post-stroke Yiyang Li, Xingping Quan, Jiacheng Hu, Yan Han, Jinfen Chen, Manfei Zhou, Fan Zhang, Yayue Yang, Mingchun Liao, Bin Wang, Yonghua Zhao
Int. J. Biol. Sci. 2025; 21(2): 842-859. doi:10.7150/ijbs.101937
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The positive feedback loop between SP1 and MAP2K2 significantly drives resistance to VEGFR inhibitors in clear cell renal cell carcinoma Zhinan Xia, Zitong Yang, Yu Dong, Xinyu Hao, Keliang Wang, Wenjiao Xia, Liangliang Ren, Tian Li, Min Xu, Guixin Zhu, Cheng Zhang
Int. J. Biol. Sci. 2025; 21(2): 860-873. doi:10.7150/ijbs.104591
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Cold atmospheric plasma potentiates ferroptosis via EGFR(Y1068)-mediated dual axes on GPX4 among triple negative breast cancer cells Xiaofeng Dai, Ziyao Xu, Xinyu Lv, Chao Li, Ruichen Jiang, Danjun Wang, Ming Xi, Tian Li
Int. J. Biol. Sci. 2025; 21(2): 874-892. doi:10.7150/ijbs.105455
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Reviews
New insights into mitochondrial quality control in anthracycline-induced cardiotoxicity: molecular mechanisms, therapeutic targets, and natural products Weili Li, Yuqin Zhang, Yan Wei, Guanjing Ling, Yawen Zhang, Yilin Li, Shujuan Guo, Nannan Tan, Lin Ma, Wei Li, Qianbin Sun, Wei Wang, Yong Wang
Int. J. Biol. Sci. 2025; 21(2): 507-523. doi:10.7150/ijbs.103810
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Fibroblasts in heterotopic ossification: mechanisms and therapeutic targets Jia-xin Li, Yan-miao Dang, Meng-chao Liu, Lin-qing Gao, Hui Lin
Int. J. Biol. Sci. 2025; 21(2): 544-564. doi:10.7150/ijbs.102297
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Regulation of INPP5E in Ciliogenesis, Development, and Disease Abdulaziz Hakeem, Shuying Yang
Int. J. Biol. Sci. 2025; 21(2): 579-594. doi:10.7150/ijbs.99010
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The Dual Role of Cellular Senescence in Macrophages: Unveiling the Hidden Driver of Age-Related Inflammation in Kidney Disease Yi-bing Wang, Tong Li, Feng-yu Wang, Xin Yao, Qiu-xiang Bai, Hong-wei Su, Jian Liu, Li Wang, Rui-zhi Tan
Int. J. Biol. Sci. 2025; 21(2): 632-657. doi:10.7150/ijbs.104404
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Involvement of Tim-3 in Maternal-fetal Tolerance: A Review of Current Understanding Xinhang Meng, Yujie Luo, Liyuan Cui, Songcun Wang
Int. J. Biol. Sci. 2025; 21(2): 789-801. doi:10.7150/ijbs.106115
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Erratum
Targeting BRD4 prevents acute gouty arthritis by regulating pyroptosis: Erratum Kun Hao, Wenjiao Jiang, Mengze Zhou, Hanwen Li, Yadong Chen, Fei Jiang, Qinghua Hu
Int. J. Biol. Sci. 2025; 21(2): 473-474. doi:10.7150/ijbs.107312
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