The Pro-angiogenesis Of Exosomes Derived From Umbilical Cord Blood Of Intrauterine Growth Restriction Pigs Was Repressed Associated With MiRNAs

Luo, Jia; Fan, Yuan; Shen, Linyuan; Niu, LiLi; Zhao, Ye; Jiang, Dongmei; Zhu, Lin; Jiang, An'an; Tang, Qianzi; Ma, Jideng; Jin, Long; Wang, Jinyong; Li, Xuewei; Zhang, Shunhua; Zhu, Li

doi:10.7150/ijbs.27029

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Int J Biol Sci 2018; 14(11):1426-1436. doi:10.7150/ijbs.27029 This issue Cite

Research Paper

The Pro-angiogenesis Of Exosomes Derived From Umbilical Cord Blood Of Intrauterine Growth Restriction Pigs Was Repressed Associated With MiRNAs

Jia Luo^1,†, Yuan Fan^1,†, Linyuan Shen¹, LiLi Niu¹, Ye Zhao¹, Dongmei Jiang¹, Lin Zhu², An'an Jiang¹, Qianzi Tang¹, Jideng Ma¹, Long Jin¹, Jinyong Wang³, Xuewei Li¹, Shunhua Zhang^1✉, Li Zhu^1✉

1. College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan, China.
2. Mianyang Ming Xing Agricultural Science and Technology Development Co., LTD, Mianyang, Sichuan, China.
3. Chongqing Academy of Animal Science, Rongchang 402460, China
† These authors contributed equally to this work.

Citation:

Luo J, Fan Y, Shen L, Niu L, Zhao Y, Jiang D, Zhu L, Jiang A, Tang Q, Ma J, Jin L, Wang J, Li X, Zhang S, Zhu L. The Pro-angiogenesis Of Exosomes Derived From Umbilical Cord Blood Of Intrauterine Growth Restriction Pigs Was Repressed Associated With MiRNAs. Int J Biol Sci 2018; 14(11):1426-1436. doi:10.7150/ijbs.27029. https://www.ijbs.com/v14p1426.htm

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Abstract

Dysfunctional umbilical cord blood (UCB) is a key factor for the development of intrauterine growth restriction (IUGR) in utero. Poor degrees of angiogenesis were observed during IUGR development. Here, it was demonstrated that NV-EXO (normal piglet's Umbilical Veins derived exosomes) promoted angiogenesis within the subdued pro-angiogenesis context of IV-EXO (IUGR piglet's Umbilical Veins derived exosomes). Investigation of the miRNA transcriptome of umbilical cord vein and artery exosomes between IUGR and normal littermates showed significant differences between umbilical veins from normal (NV) and IUGR (IV) piglets. Similar patterns were observed in normal (NA) and IUGR (IA) umbilical arteries as well. Moreover, the miRNAs expession level was more stable in NV. Further analysis revealed that miRNAs related to angiogenesis exhibited aberrant expression in IUGR pigs. The miRNA expression patterns between IUGR and normal piglets showed great difference. Expression of miR-150 in the tissues and UCB exosomes of IUGR pigs was significantly decreased. Up-regulation of miR-150 was able to increase proliferation, migration and tube formation of Human umbilical vein endothelial cells (HUVECs), suggesting a pro-angiogenic role. Furthermore, the data demonstrated that UCB derived miRNAs participate in fetal epigenetic regulation during pregnancy, suggesting a novel possible explanation for abnormal embryologic vascular development and several congenital cardiovascular diseases.

Keywords: IUGR, pig, umbilical cord blood, exosomes, angiogenesis, miRNA

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APA

Luo, J., Fan, Y., Shen, L., Niu, L., Zhao, Y., Jiang, D., Zhu, L., Jiang, A., Tang, Q., Ma, J., Jin, L., Wang, J., Li, X., Zhang, S., Zhu, L. (2018). The Pro-angiogenesis Of Exosomes Derived From Umbilical Cord Blood Of Intrauterine Growth Restriction Pigs Was Repressed Associated With MiRNAs. International Journal of Biological Sciences, 14(11), 1426-1436. https://doi.org/10.7150/ijbs.27029.

ACS

Luo, J.; Fan, Y.; Shen, L.; Niu, L.; Zhao, Y.; Jiang, D.; Zhu, L.; Jiang, A.; Tang, Q.; Ma, J.; Jin, L.; Wang, J.; Li, X.; Zhang, S.; Zhu, L. The Pro-angiogenesis Of Exosomes Derived From Umbilical Cord Blood Of Intrauterine Growth Restriction Pigs Was Repressed Associated With MiRNAs. Int. J. Biol. Sci. 2018, 14 (11), 1426-1436. DOI: 10.7150/ijbs.27029.

NLM

CSE

Luo J, Fan Y, Shen L, Niu L, Zhao Y, Jiang D, Zhu L, Jiang A, Tang Q, Ma J, Jin L, Wang J, Li X, Zhang S, Zhu L. 2018. The Pro-angiogenesis Of Exosomes Derived From Umbilical Cord Blood Of Intrauterine Growth Restriction Pigs Was Repressed Associated With MiRNAs. Int J Biol Sci. 14(11):1426-1436.

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