Int J Biol Sci 2019; 15(1):1-11. doi:10.7150/ijbs.27796
Current Progresses of Exosomes as Cancer Diagnostic and Prognostic Biomarkers
Faculty of Health Sciences, University of Macau, Macau SAR, China
Huang T, Deng CX. Current Progresses of Exosomes as Cancer Diagnostic and Prognostic Biomarkers. Int J Biol Sci 2019; 15(1):1-11. doi:10.7150/ijbs.27796. Available from http://www.ijbs.com/v15p0001.htm
Cancer related exosomes are nano-size membrane vesicles that play important roles in tumor microenvironment. Emerging evidence indicates that exosomes can load unique cargoes, including proteins and nucleic acids that reflect the condition of tumor. Therefore, exosomes are being used as diagnostic and prognostic biomarkers for various cancers. In this review, we describe the current progresses of cancer related exosomes, including their biogenesis, molecular contents, biological functions, sources where they are derived from, and methods for their detection. We will also discuss the current exosomal biomarkers and the utilization of them for early diagnosis and prognostics in cancer.
Keywords: exosomes, cancer, biomarkers, therapy, diagnosis, prognosis