Int J Biol Sci 2020; 16(5):730-738. doi:10.7150/ijbs.40923
Multiple Roles of sFRP2 in Cardiac Development and Cardiovascular Disease
1. Department of Cardiology, Shunde hospital, Southern Medical University, Jiazi Road 1 Lunjiao Town, Shunde District, Foshan, Guangdong, 528308, China.
2. Department of Cardiology, The First Affiliated Hospital of Sun Yat-sen University, 510080, Guangzhou
3. The George Institute for Global Health, NSW 2042 Australia
Wu Y, Liu X, Zheng H, Zhu H, Mai W, Huang X, Huang Y. Multiple Roles of sFRP2 in Cardiac Development and Cardiovascular Disease. Int J Biol Sci 2020; 16(5):730-738. doi:10.7150/ijbs.40923. Available from http://www.ijbs.com/v16p0730.htm
The Wnt signaling pathway plays important roles in organ development and disease processes. Secreted frizzled-related protein 2 (sFRP2), a vital molecule of Wnt signaling, can regulate cardiac development and cardiovascular disease. Recent studies have suggested that sFRP2 is not only an antagonist of the canonical Wnt signaling pathway, but also has a more complex relationship in myocardial fibrosis, angiogenesis, cardiac hypertrophy and cardiac regeneration. Here, we review the role of sFRP2 and Wnt signaling in cardiac development and cardiovascular disease.
Keywords: Wnt Signaling, Secreted frizzled-related protein 2, Cardiac Fibrosis, Angiogenesis, Hypertrophy, Cardiac development