Int J Biol Sci 2020; 16(5):803-814. doi:10.7150/ijbs.39212

Review

Circular RNA in Lung Cancer Research: Biogenesis, Functions, and Roles

Congcong Zhang1,2*, Lifang Ma2*, Yongjie Niu1,2, Zhixian Wang1,2, Xin Xu1,2, Yan Li3✉, Yongchun Yu1,2✉

1. Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200071, P.R. China.
2. Institute for Thoracic Oncology, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, 200030, P.R. China.
3. Department of Oncology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai,200071, P.R. China.
* These authors contributed equally to this study.

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Citation:
Zhang C, Ma L, Niu Y, Wang Z, Xu X, Li Y, Yu Y. Circular RNA in Lung Cancer Research: Biogenesis, Functions, and Roles. Int J Biol Sci 2020; 16(5):803-814. doi:10.7150/ijbs.39212. Available from http://www.ijbs.com/v16p0803.htm

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Abstract

Lung cancer is one of the most common and deadly malignancies worldwide, in spite of advances in targeted therapy in recent years. An effective strategy for lung cancer prevention remains a major problem. Advances in next-generation sequencing have helped in understanding the RNA and identifying novel circular RNAs (circRNAs) that may have a broad impact on the early diagnosis and treatment of lung cancer. The circRNAs, exhibiting spatiotemporal-specific expression, are stable and conserved and present diverse biological functions in the normal and diseased states, including cancer. In this review, we summarize the recent advances in elucidating the functional role of circRNAs in lung cancer pathogenesis and discuss their potential mechanisms.

Keywords: Lung cancer, circRNA, diagnostic biomarker, therapeutic targets