Full Text | PDF

Share on tweeters Share on facebook Share on linkedin Share on googleplus

Int J Biol Sci 2020; 16(8):1463-1473. doi:10.7150/ijbs.40834 This issue Cite

Review

Transcription Factor RREB1: from Target Genes towards Biological Functions

Ya-Nan Deng1, Zijing Xia1,2, Peng Zhang3, Samina Ejaz4, Shufang Liang1✉

1. State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, No.17, 3rd Section of People's South Road, Chengdu, 610041, P.R. China.
2. Department of Rheumatology, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, P. R. China.
3. Department of Urinary Surgery, West China Hospital, West China Medical School, Sichuan University, Chengdu, 610041, P. R. China.
4. Department of Biochemistry and Biotechnology, Baghdad Campus, The Islamia University of Bahawalpur, Pakistan.

✉ Corresponding author: Dr. Shufang Liang, Department of Biotherapy, Caner Center, West China Hospital, Sichuan University, No.17, 3rd Section of People's South Road, Chengdu, 610041, P. R. China. E-mail: zizi2006edu.cn.

Citation:
Deng YN, Xia Z, Zhang P, Ejaz S, Liang S. Transcription Factor RREB1: from Target Genes towards Biological Functions. Int J Biol Sci 2020; 16(8):1463-1473. doi:10.7150/ijbs.40834. https://www.ijbs.com/v16p1463.htm
Other styles

File import instruction

Abstract

Graphic abstract

The Ras-responsive element binding protein 1(RREB1) is a member of zinc finger transcription factors, which is widely involved in biological processes including cell proliferation, transcriptional regulation and DNA damage repair. New findings reveal RREB1 functions as both transcriptional repressors and transcriptional activators for transcriptional regulation of target genes. The activation of RREB1 is regulated by MAPK pathway. We have summarized the target genes of RREB1 and discussed RREB1 roles in the cancer development. In addition, increasing evidences suggest that RREB1 is a potential risk gene for type 2 diabetes and obesity. We also review the current clinical application of RREB1 as a biomarker for melanoma detection. In conclusion, RREB1 is a promising diagnostic biomarker or new drug target for cancers and metabolic diseases.

Keywords: RREB1, cancer, metabolic disease, MAPK pathway

Citation styles

APA
Deng, Y.N., Xia, Z., Zhang, P., Ejaz, S., Liang, S. (2020). Transcription Factor RREB1: from Target Genes towards Biological Functions. International Journal of Biological Sciences, 16(8), 1463-1473. https://doi.org/10.7150/ijbs.40834.

ACS
Deng, Y.N.; Xia, Z.; Zhang, P.; Ejaz, S.; Liang, S. Transcription Factor RREB1: from Target Genes towards Biological Functions. Int. J. Biol. Sci. 2020, 16 (8), 1463-1473. DOI: 10.7150/ijbs.40834.

NLM
Deng YN, Xia Z, Zhang P, Ejaz S, Liang S. Transcription Factor RREB1: from Target Genes towards Biological Functions. Int J Biol Sci 2020; 16(8):1463-1473. doi:10.7150/ijbs.40834. https://www.ijbs.com/v16p1463.htm

CSE
Deng YN, Xia Z, Zhang P, Ejaz S, Liang S. 2020. Transcription Factor RREB1: from Target Genes towards Biological Functions. Int J Biol Sci. 16(8):1463-1473.

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
Popup Image

©2024 Ivyspring International Publisher. Terms of use