Int J Biol Sci
2020; 16(8):1474-1480.
doi:10.7150/ijbs.39958 This issueCite
Review
The role of WT1 in breast cancer: clinical implications, biological effects and molecular mechanism
Ye Zhang1*, Wen-Ting Yan1*, Ze-Yu Yang2*, Yan-Ling Li1, Xuan-Ni Tan1, Jun Jiang1, Yi Zhang1, Xiao-Wei Qi1✉
1. Breast and Thyroid Surgery, Southwest Hospital, Army Medical University, Chongqing 400038, China 2. Breast and Thyroid Surgery, Chongqing General Hospital, University of Chinese Academy of Sciences, Chongqing 400013, China *Contributed equally
✉ Corresponding author: Dr. Xiao-Wei Qi, Breast and Thyroid Surgery, Southwest Hospital, Army Medical University, Gaotanyan Street 29, Chongqing 400038, China. Tel.: 86-23-68754160, Fax.: 86-23-68754160, E-mail: qxw9908com
Citation:
Zhang Y, Yan WT, Yang ZY, Li YL, Tan XN, Jiang J, Zhang Y, Qi XW. The role of WT1 in breast cancer: clinical implications, biological effects and molecular mechanism. Int J Biol Sci 2020; 16(8):1474-1480. doi:10.7150/ijbs.39958. https://www.ijbs.com/v16p1474.htm
Although Wilms' tumor gene 1 (WT1) was first cloned and identified as a tumor suppressor gene in nephroblastoma, subsequent studies have demonstrated that it can also play an oncogenic role in leukemia and various solid tumors. WT1 exerts biological functions with high tissue- and cell-specificity. This article reviews the relationship between WT1 and breast cancer from two aspects: (1) clinical application of WT1, including the relationship between expression of WT1 and prognosis of breast cancer patients, and its effectiveness as a target for comprehensive therapy of breast cancer; (2) the biological effects and molecular mechanisms of WT1 in the development and progression of breast cancer, including proliferation, apoptosis, invasion, and metastasis of breast cancer cells.
Keywords: WT1, breast neoplasms, prognosis, carcinogenesis
Citation styles
APA
Zhang, Y., Yan, W.T., Yang, Z.Y., Li, Y.L., Tan, X.N., Jiang, J., Zhang, Y., Qi, X.W. (2020). The role of WT1 in breast cancer: clinical implications, biological effects and molecular mechanism. International Journal of Biological Sciences, 16(8), 1474-1480. https://doi.org/10.7150/ijbs.39958.
ACS
Zhang, Y.; Yan, W.T.; Yang, Z.Y.; Li, Y.L.; Tan, X.N.; Jiang, J.; Zhang, Y.; Qi, X.W. The role of WT1 in breast cancer: clinical implications, biological effects and molecular mechanism. Int. J. Biol. Sci. 2020, 16 (8), 1474-1480. DOI: 10.7150/ijbs.39958.
NLM
Zhang Y, Yan WT, Yang ZY, Li YL, Tan XN, Jiang J, Zhang Y, Qi XW. The role of WT1 in breast cancer: clinical implications, biological effects and molecular mechanism. Int J Biol Sci 2020; 16(8):1474-1480. doi:10.7150/ijbs.39958. https://www.ijbs.com/v16p1474.htm
CSE
Zhang Y, Yan WT, Yang ZY, Li YL, Tan XN, Jiang J, Zhang Y, Qi XW. 2020. The role of WT1 in breast cancer: clinical implications, biological effects and molecular mechanism. Int J Biol Sci. 16(8):1474-1480.
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