Int J Biol Sci 2020; 16(8):1474-1480. doi:10.7150/ijbs.39958 This issue

Review

The role of WT1 in breast cancer: clinical implications, biological effects and molecular mechanism

Ye Zhang1*, Wen-Ting Yan1*, Ze-Yu Yang2*, Yan-Ling Li1, Xuan-Ni Tan1, Jun Jiang1, Yi Zhang1, Xiao-Wei Qi1✉

1. Breast and Thyroid Surgery, Southwest Hospital, Army Medical University, Chongqing 400038, China
2. Breast and Thyroid Surgery, Chongqing General Hospital, University of Chinese Academy of Sciences, Chongqing 400013, China
*Contributed equally

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Citation:
Zhang Y, Yan WT, Yang ZY, Li YL, Tan XN, Jiang J, Zhang Y, Qi XW. The role of WT1 in breast cancer: clinical implications, biological effects and molecular mechanism. Int J Biol Sci 2020; 16(8):1474-1480. doi:10.7150/ijbs.39958. Available from https://www.ijbs.com/v16p1474.htm

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Abstract

Graphic abstract

Although Wilms' tumor gene 1 (WT1) was first cloned and identified as a tumor suppressor gene in nephroblastoma, subsequent studies have demonstrated that it can also play an oncogenic role in leukemia and various solid tumors. WT1 exerts biological functions with high tissue- and cell-specificity. This article reviews the relationship between WT1 and breast cancer from two aspects: (1) clinical application of WT1, including the relationship between expression of WT1 and prognosis of breast cancer patients, and its effectiveness as a target for comprehensive therapy of breast cancer; (2) the biological effects and molecular mechanisms of WT1 in the development and progression of breast cancer, including proliferation, apoptosis, invasion, and metastasis of breast cancer cells.

Keywords: WT1, breast neoplasms, prognosis, carcinogenesis