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Int J Biol Sci 2020; 16(15):2883-2894. doi:10.7150/ijbs.45710 This issue Cite

Research Paper

Dioscin facilitates ROS-induced apoptosis via the p38-MAPK/HSP27-mediated pathways in lung squamous cell carcinoma

Yinan Yao#, Luyun Cui#, Jiani Ye, Guangdie Yang, Guohua Lu, Xiaomei Fang, Zhu Zeng, Jianying Zhou✉

Department of Respiratory Medicine, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
#These authors contributed equally to this work.

✉ Corresponding author: Jianying Zhou, E-mail: zjyhzedu.cn; Department of Respiratory Medicine, The First Affiliated Hospital, College of Medicine, Zhejiang University, Qingchun Road 79, Xiacheng District, Hangzhou, China.

Citation:
Yao Y, Cui L, Ye J, Yang G, Lu G, Fang X, Zeng Z, Zhou J. Dioscin facilitates ROS-induced apoptosis via the p38-MAPK/HSP27-mediated pathways in lung squamous cell carcinoma. Int J Biol Sci 2020; 16(15):2883-2894. doi:10.7150/ijbs.45710. https://www.ijbs.com/v16p2883.htm
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Abstract

Graphic abstract

Lung squamous cell carcinoma (SCC) is one of the deadliest cancers both in China and worldwide. To date, the efficacy of lung SCC treatments is limited. Recent studies have elucidated the powerful anti-tumour role of dioscin in different human cancers. Here, our study aims to investigate the effect of dioscin on lung SCC and its underlying mechanism. First, we found that dioscin not only inhibited cell proliferation and cell migration and induced cell apoptosis in lung SCC cells but also suppressed tumour growth in tumour-bearing mice. Furthermore, we noted that the accumulation of intracellular reactive oxygen species (ROS) was triggered by dioscin in lung SCC cells, leading to the phosphorylation of HSP27 through p38-MAPK and consequent cell apoptosis. The activation of p38-MAPK/HSP27 induced by the p38-MAPK activator Anisomycin enhanced the apoptosis of lung SCC cells, while the ROS inhibitor N-acetyl-L-cysteine (NAC) and the p38-MAPK inhibitor SB203580 both attenuated dioscin-mediated cell apoptosis. Moreover, NAC suppressed the activation of p38-MAPK/HSP27 that induced by dioscin. In conclusion, these results confirm that dioscin facilitates ROS-induced apoptosis via the p38-MAPK/HSP27-mediated pathway in lung SCC.

Keywords: lung SCC, dioscin, cell apoptosis, ROS, p38-MAPK

Citation styles

APA
Yao, Y., Cui, L., Ye, J., Yang, G., Lu, G., Fang, X., Zeng, Z., Zhou, J. (2020). Dioscin facilitates ROS-induced apoptosis via the p38-MAPK/HSP27-mediated pathways in lung squamous cell carcinoma. International Journal of Biological Sciences, 16(15), 2883-2894. https://doi.org/10.7150/ijbs.45710.

ACS
Yao, Y.; Cui, L.; Ye, J.; Yang, G.; Lu, G.; Fang, X.; Zeng, Z.; Zhou, J. Dioscin facilitates ROS-induced apoptosis via the p38-MAPK/HSP27-mediated pathways in lung squamous cell carcinoma. Int. J. Biol. Sci. 2020, 16 (15), 2883-2894. DOI: 10.7150/ijbs.45710.

NLM
Yao Y, Cui L, Ye J, Yang G, Lu G, Fang X, Zeng Z, Zhou J. Dioscin facilitates ROS-induced apoptosis via the p38-MAPK/HSP27-mediated pathways in lung squamous cell carcinoma. Int J Biol Sci 2020; 16(15):2883-2894. doi:10.7150/ijbs.45710. https://www.ijbs.com/v16p2883.htm

CSE
Yao Y, Cui L, Ye J, Yang G, Lu G, Fang X, Zeng Z, Zhou J. 2020. Dioscin facilitates ROS-induced apoptosis via the p38-MAPK/HSP27-mediated pathways in lung squamous cell carcinoma. Int J Biol Sci. 16(15):2883-2894.

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