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Volume 17 (10); 2021

Research Papers

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Cx43 deficiency confers EMT-mediated tamoxifen resistance to breast cancer via c-Src/PI3K/Akt pathway
Deng-Pan Wu, Yan Zhou, Li-Xiang Hou, Xiao-Xiao Zhu, Wen Yi, Si-Man Yang, Tian-Yu Lin, Jin-Lan Huang, Bei Zhang, Xiao-Xing Yin
Int. J. Biol. Sci. 2021; 17(10): 2380-2398. doi:10.7150/ijbs.55453
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Soluble Receptor for Advanced Glycation End-products regulates age-associated Cardiac Fibrosis
Francesco Scavello, Filippo Zeni, Giuseppina Milano, Federica Macrì, Stefania Castiglione, Estella Zuccolo, Alessandro Scopece, Giovanni Pezone, Calogero C. Tedesco, Patrizia Nigro, Genny Degani, Elisa Gambini, Fabrizio Veglia, Laura Popolo, Giulio Pompilio, Gualtiero I. Colombo, Marco E. Bianchi, Angela Raucci
Int. J. Biol. Sci. 2021; 17(10): 2399-2416. doi:10.7150/ijbs.56379
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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USP24-GSDMB complex promotes bladder cancer proliferation via activation of the STAT3 pathway
Haiqing He, Lu Yi, Bin Zhang, Bin Yan, Ming Xiao, Jiannan Ren, Dong Zi, Liang Zhu, Zhaohui Zhong, Xiaokun Zhao, Xin Jin, Wei Xiong
Int. J. Biol. Sci. 2021; 17(10): 2417-2429. doi:10.7150/ijbs.54442
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Osteocytes but not osteoblasts directly build mineralized bone structures
Ke Wang, Yinshi Ren, Shuxian Lin, Yan Jing, Chi Ma, Jun Wang, X. Baozhi Yuan, Xianglong Han, Hu Zhao, Zheng Wang, Minghao Zheng, Yin Xiao, Lin Chen, Bjorn Reino Olsen, Jian Q. Feng
Int. J. Biol. Sci. 2021; 17(10): 2430-2448. doi:10.7150/ijbs.61012
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Combination of Ferulic Acid, Ligustrazine and Tetrahydropalmatine attenuates Epithelial-mesenchymal Transformation via Wnt/β-catenin Pathway in Endometriosis
Chengling Zhang, Ying Zhang, Haiying Pan, Yi Tan, Qinghua Wei, Xueshan Dai, Jiahui Wei, Yi Chen
Int. J. Biol. Sci. 2021; 17(10): 2449-2460. doi:10.7150/ijbs.60167
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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BCAR1 plays critical roles in the formation and immunoevasion of invasive circulating tumor cells in lung adenocarcinoma
Chun-Guo Mao, Sha-sha Jiang, Xiao-yang Wang, Shao-Lin Tao, Bin Jiang, Cheng-Yi Mao, Yan-Lian Yang, Zhi-Yuan Hu, Tan Long, Hua Jin, Qun-You Tan, Yi Huang, Bo Deng
Int. J. Biol. Sci. 2021; 17(10): 2461-2475. doi:10.7150/ijbs.61790
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Cantharidin inhibits osteosarcoma proliferation and metastasis by directly targeting miR-214-3p/DKK3 axis to inactivate β-catenin nuclear translocation and LEF1 translation
Shaopu Hu, Junli Chang, Hongfeng Ruan, Wenlan Zhi, Xiaobo Wang, Fulai Zhao, Xiaoping Ma, Xingyuan Sun, Qianqian Liang, Hao Xu, Yongjun Wang, Yanping Yang
Int. J. Biol. Sci. 2021; 17(10): 2504-2522. doi:10.7150/ijbs.51638
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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MUC3A promotes non-small cell lung cancer progression via activating the NFκB pathway and attenuates radiosensitivity
Yingming Sun, Xiaoge Sun, Chengcheng You, Shijing Ma, Yuan Luo, Shan Peng, Fang Tang, Xiaoli Tian, Feng Wang, Zhengrong Huang, Hongnv Yu, Yu Xiao, Xiaoyong Wang, Junhong Zhang, Yan Gong, Conghua Xie
Int. J. Biol. Sci. 2021; 17(10): 2523-2536. doi:10.7150/ijbs.59430
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Celastrol ameliorates vascular neointimal hyperplasia through Wnt5a-involved autophagy
Ya-Ning Shi, Le-Ping Liu, Chang-Feng Deng, Tan-Jun Zhao, Zhe Shi, Jian-Ye Yan, Yong-Zhen Gong, Duan-Fang Liao, Li Qin
Int. J. Biol. Sci. 2021; 17(10): 2561-2575. doi:10.7150/ijbs.58715
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Aberrant FGFR4 signaling worsens nonalcoholic steatohepatitis in FGF21KO mice
Youxi Yu, Xiaoju Shi, Qianqian Zheng, Xingtong Wang, Xingkai Liu, Min Tan, Guoyue Lv, Ping Zhang, Robert C. Martin, Yan Li
Int. J. Biol. Sci. 2021; 17(10): 2576-2589. doi:10.7150/ijbs.58776
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Single-cell transcriptomics reveals heterogeneous progression and EGFR activation in pancreatic adenosquamous carcinoma
Xin Zhao, Han Li, Shaocheng Lyu, Jialei Zhai, Zhiwei Ji, Zhigang Zhang, Xinxue Zhang, Zhe Liu, Huaguang Wang, Junming Xu, Hua Fan, Jiantao Kou, Lixin Li, Ren Lang, Qiang He
Int. J. Biol. Sci. 2021; 17(10): 2590-2605. doi:10.7150/ijbs.58886
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Cisplatin Induces Pyroptosis via Activation of MEG3/NLRP3/caspase-1/GSDMD Pathway in Triple-Negative Breast Cancer
Honglin Yan, Bin Luo, Xiaoyan Wu, Feng Guan, Xinxin Yu, Lina Zhao, Xiaokang Ke, Juan Wu, Jingping Yuan
Int. J. Biol. Sci. 2021; 17(10): 2606-2621. doi:10.7150/ijbs.60292
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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RHOV promotes lung adenocarcinoma cell growth and metastasis through JNK/c-Jun pathway
Deyu Zhang, Qiwei Jiang, Xiangwei Ge, Yanzhu Shi, Tianxing Ye, Yue Mi, Tian Xie, Qihong Li, Qinong Ye
Int. J. Biol. Sci. 2021; 17(10): 2622-2632. doi:10.7150/ijbs.59939
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Downregulation of m6A Reader YTHDC2 Promotes the Proliferation and Migration of Malignant Lung Cells via CYLD/NF-κB Pathway
Jin Wang, Lirong Tan, Beibei Jia, Xiaofan Yu, Ruixin Yao, Nan OUYang, Xueting Yu, Xiyuan Cao, Jian Tong, Tao Chen, Rui Chen, Jianxiang Li
Int. J. Biol. Sci. 2021; 17(10): 2633-2651. doi:10.7150/ijbs.58514
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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The Spleen Tyrosine Kinase Inhibitor, Entospletinib (GS-9973) Restores Chemosensitivity in Lung Cancer Cells by Modulating ABCG2-mediated Multidrug Resistance
Silpa Narayanan, Zhuo-Xun Wu, Jing-Quan Wang, Hansu Ma, Nikita Acharekar, Jagadish Koya, Sabesan Yoganathan, Shuo Fang, Zhe-Sheng Chen, Yihang Pan
Int. J. Biol. Sci. 2021; 17(10): 2652-2665. doi:10.7150/ijbs.61229
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Reviews

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Emerging Significance and Therapeutic Potential of Extracellular vesicles
Ruhua Luo, Mengmeng Liu, Tiantian Tan, Qian Yang, Yue Wang, Lianhui Men, Liping Zhao, Honghua Zhang, Shuling Wang, Tian Xie, Qingchang Tian
Int. J. Biol. Sci. 2021; 17(10): 2476-2486. doi:10.7150/ijbs.59296
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Towards Post-Meiotic Sperm Production: Genetic Insight into Human Infertility from Mouse Models
Muhammad Azhar, Saba Altaf, Islam Uddin, Jinbao Cheng, Limin Wu, Xianhong Tong, Weibing Qin, Jianqiang Bao
Int. J. Biol. Sci. 2021; 17(10): 2487-2503. doi:10.7150/ijbs.60384
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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New insights into the important roles of tumor cell-intrinsic PD-1
Hongmei Zheng, Yue Ning, Yuting Zhan, Sile Liu, Qiuyuan Wen, Songqing Fan
Int. J. Biol. Sci. 2021; 17(10): 2537-2547. doi:10.7150/ijbs.60114
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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The Role of Cyclophilins in Inflammatory Bowel Disease and Colorectal Cancer
Lifang Liang, Rongxiao Lin, Ying Xie, Huaqing Lin, Fangyuan Shao, Wen Rui, Hongyuan Chen
Int. J. Biol. Sci. 2021; 17(10): 2548-2560. doi:10.7150/ijbs.58671
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Microorganisms in chemotherapy for pancreatic cancer: An overview of current research and future directions
Si-Yuan Lu, Jie Hua, Jin Xu, Miao-Yan Wei, Chen Liang, Qing-Cai Meng, Jiang Liu, Bo Zhang, Wei Wang, Xian-Jun Yu, Si Shi
Int. J. Biol. Sci. 2021; 17(10): 2666-2682. doi:10.7150/ijbs.59117
[Abstract] [Full text] [PDF] [PubMed] [PMC]