Int J Biol Sci 2021; 17(12):3173-3187. doi:10.7150/ijbs.62556 This issue

Research Paper

Berberine modulates deacetylation of PPARγ to promote adipose tissue remodeling and thermogenesis via AMPK/SIRT1 pathway

Yingxi Xu1,2, Tianhao Yu4, Guojing Ma2, Lixia Zheng2, Xuehan Jiang2, Fan Yang2, Zhuo Wang2, Na Li2, Zheng He5, Xiaoyu Song2, Deliang Wen3✉, Juan Kong1✉, Yang Yu2,3✉, Liu Cao2✉

1. Department of Clinical Nutrition, Shengjing Hospital of China Medical University, Shenyang, 110004, China.
2. College of Basic Medical Science, Institute of Translational Medicine, Key Laboratory of Medical Cell Biology, Ministry of Education, Key Laboratory of Liaoning Province, China Medical University, Shenyang, Liaoning Province, P.R. China, 110122.
3. Institute of Health Sciences, China Medical University, Shenyang 110122, Liaoning, China
4. The VIP Department, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Shenyang, 110002, China.
5. Department of Radiation Oncology, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China.

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Citation:
Xu Y, Yu T, Ma G, Zheng L, Jiang X, Yang F, Wang Z, Li N, He Z, Song X, Wen D, Kong J, Yu Y, Cao L. Berberine modulates deacetylation of PPARγ to promote adipose tissue remodeling and thermogenesis via AMPK/SIRT1 pathway. Int J Biol Sci 2021; 17(12):3173-3187. doi:10.7150/ijbs.62556. Available from https://www.ijbs.com/v17p3173.htm

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Abstract

Graphic abstract

Pharmacological stimulation of adipose tissue remodeling and thermogenesis to increase energy expenditure is expected to be a viable therapeutic strategy for obesity. Berberine has been reported to have pharmacological activity in adipose tissue to anti-obesity, while the mechanism remains unclear. Here, we observed that berberine significantly reduced the body weight and insulin resistance of high-fat diet mice by promoting the distribution of brown adipose tissue and thermogenesis. We have further demonstrated that berberine activated energy metabolic sensing pathway AMPK/SIRT1 axis to increase the level of PPARγ deacetylation, which leads to promoting adipose tissue remodeling and increasing the expression of the thermogenic protein UCP-1. These findings suggest that berberine that enhances the AMPK/SIRT1 pathway can act as a selective PPARγ activator to promote adipose tissue remodeling and thermogenesis. This study proposes a new mechanism for the regulation of berberine in adipose tissue and offers a great prospect for berberine in obesity treatment

Keywords: Berberine, Adipose tissue, Deacetylation, PPARγ, AMPK/SIRT1 axis