Int J Biol Sci 2021; 17(13):3441-3455. doi:10.7150/ijbs.58872 This issue

Review

The Function and related Diseases of Protein Crotonylation

Shuo Wang1, Guanqun Mu1, Bingquan Qiu1, Meng Wang1, Zunbo Yu2, Weibin Wang3, Jiadong Wang3, Yang Yang1✉

1. Department of Biochemistry and Molecular Biology, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, School of Basic Medical Sciences, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China.
2. China Institute of Veterinary Drugs Control, Beijing 100181, China.
3. Department of Radiation Medicine, Institute of Systems Biomedicine, School of Basic Medical Sciences, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China.

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
Citation:
Wang S, Mu G, Qiu B, Wang M, Yu Z, Wang W, Wang J, Yang Y. The Function and related Diseases of Protein Crotonylation. Int J Biol Sci 2021; 17(13):3441-3455. doi:10.7150/ijbs.58872. Available from https://www.ijbs.com/v17p3441.htm

File import instruction

Abstract

Graphic abstract

Crotonylation is a kind of newly discovered acylation modification. Thousands of crotonylation sites have been identified in histone and non-histone proteins over the past decade. As a modification closely related to acetylation, crotonylation was reported to share many universal enzymes with acetylation. Crotonylated proteins have important roles in the regulation of various biological processes, such as gene expression, process of spermatogenesis, cell cycle, and also in the pathogenesis of different diseases, which range from depression to cancer. In this review, we summarize the research processes of crotonylation and discuss the advances of regulation mechanism of both histone and non-histone proteins crotonylation in difference physiological processes. Also, we focus on the alteration of the crotonylation under certain pathological conditions and its role in the pathogenesis of each disease.

Keywords: crotonylation, histone crotonylation, non-histone crotonylation, disease