Int J Biol Sci 2022; 18(2):675-692. doi:10.7150/ijbs.63721 This issue

Review

Overview of follicle stimulating hormone and its receptors in reproduction and in stem cells and cancer stem cells

Swati Haldar1,2, Himanshu Agrawal1, Sarama Saha3, Alex R. Straughn4, Partha Roy1, Sham S. Kakar4✉

1. Molecular Endocrinology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Roorkee, Uttarakhand 247667, India.
2. Current address: Drug Discovery and Development Division, Patanjali Research Institute, Haridwar, Uttarakhand 249405.
3. Department of Biochemistry, All India Institute of Medical Sciences Rishikesh, Uttarakhand 249203, India.
4. Department of Physiology, James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA.

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Citation:
Haldar S, Agrawal H, Saha S, Straughn AR, Roy P, Kakar SS. Overview of follicle stimulating hormone and its receptors in reproduction and in stem cells and cancer stem cells. Int J Biol Sci 2022; 18(2):675-692. doi:10.7150/ijbs.63721. Available from https://www.ijbs.com/v18p0675.htm

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Abstract

Graphic abstract

Follicle stimulating hormone (FSH) and its receptor (FSHR) have been reported to be responsible for several physiological functions and cancers. The responsiveness of stem cells and cancer stem cells towards the FSH-FSHR system make the function of FSH and its receptors more interesting in the context of cancer biology. This review is comprised of comprehensive information on FSH-FSHR signaling in normal physiology, gonadal stem cells, cancer cells, and potential options of utilizing FSH-FSHR system as an anti-cancer therapeutic target.