Int J Biol Sci 2022; 18(13):4950-4962. doi:10.7150/ijbs.75488 This issue Cite

Review

Regulation of Adipose Thermogenesis and its Critical Role in Glucose and Lipid Metabolism

Linghui Wang1,2*, Yanhao Qiu1,2*, Hao Gu1,2*, Mailin Gan1,2, Yan Zhu3, Kangping Zhu4, Lei Chen1,2, Ye Zhao1,2, Lili Niu1,2, Shunhua Zhang1,2, Xuewei Li1,2, Li Zhu1,2✉, Linyuan Shen1,2✉

1. Department of Animal Science, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.
2. Farm Animal Genetic Resource Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, China.
3. College of Life Science, China West Normal University, Nanchong 637009, Sichuan, PR China.
4. Sichuan Dekon Livestock Foodstuff Group, Chengdu 610200, China.
* These authors contributed equally to this work.

Citation:
Wang L, Qiu Y, Gu H, Gan M, Zhu Y, Zhu K, Chen L, Zhao Y, Niu L, Zhang S, Li X, Zhu L, Shen L. Regulation of Adipose Thermogenesis and its Critical Role in Glucose and Lipid Metabolism. Int J Biol Sci 2022; 18(13):4950-4962. doi:10.7150/ijbs.75488. https://www.ijbs.com/v18p4950.htm
Other styles

File import instruction

Abstract

Graphic abstract

The function of the adipose tissue is influenced by complex interactions between genetics, epigenetics, and the environment, and its dysfunction can cause a variety of metabolic diseases, such as obesity or type 2 diabetes (T2D). The beige/brown adipose tissue plays a crucial role in regulating glucose and lipid metabolism by increasing energy metabolism to generate heat. The adipose tissue thermogenic program is a complex network that involves many signaling pathways regulated by coding RNAs (cRNAs) that encode transcription factor, and non-coding RNAs (ncRNAs) including microRNAs (miRNAs) and long noncoding RNAs (lncRNAs). This article discusses factors that regulate adipose tissue thermogenesis, including cRNAs and ncRNAs, and the important role of thermogenic adipose tissue in obesity-related metabolic syndrome. Several studies have shown that some cRNAs and ncRNAs can modulate the thermogenic function of adipose tissue in different ways. This article reviews the roles of cRNAs and ncRNAs in regulating thermogenesis in the beige/brown adipose tissue and the important role of the beige/brown adipose tissue in maintaining the balance of glucose and lipid metabolism in the body.

Keywords: Brown adipose, Beige adipose, Coding RNA, Non-coding RNA, thermogenesis, Obesity, metabolic syndrome


Citation styles

APA
Wang, L., Qiu, Y., Gu, H., Gan, M., Zhu, Y., Zhu, K., Chen, L., Zhao, Y., Niu, L., Zhang, S., Li, X., Zhu, L., Shen, L. (2022). Regulation of Adipose Thermogenesis and its Critical Role in Glucose and Lipid Metabolism. International Journal of Biological Sciences, 18(13), 4950-4962. https://doi.org/10.7150/ijbs.75488.

ACS
Wang, L.; Qiu, Y.; Gu, H.; Gan, M.; Zhu, Y.; Zhu, K.; Chen, L.; Zhao, Y.; Niu, L.; Zhang, S.; Li, X.; Zhu, L.; Shen, L. Regulation of Adipose Thermogenesis and its Critical Role in Glucose and Lipid Metabolism. Int. J. Biol. Sci. 2022, 18 (13), 4950-4962. DOI: 10.7150/ijbs.75488.

NLM
Wang L, Qiu Y, Gu H, Gan M, Zhu Y, Zhu K, Chen L, Zhao Y, Niu L, Zhang S, Li X, Zhu L, Shen L. Regulation of Adipose Thermogenesis and its Critical Role in Glucose and Lipid Metabolism. Int J Biol Sci 2022; 18(13):4950-4962. doi:10.7150/ijbs.75488. https://www.ijbs.com/v18p4950.htm

CSE
Wang L, Qiu Y, Gu H, Gan M, Zhu Y, Zhu K, Chen L, Zhao Y, Niu L, Zhang S, Li X, Zhu L, Shen L. 2022. Regulation of Adipose Thermogenesis and its Critical Role in Glucose and Lipid Metabolism. Int J Biol Sci. 18(13):4950-4962.

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.