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Int J Biol Sci 2023; 19(4):1178-1191. doi:10.7150/ijbs.79430 This issue Cite

Review

The role of gut microbiota in T cell immunity and immune mediated disorders

Ju A Shim1, Jeong Ha Ryu1,2, Yuna Jo1, Changwan Hong1,2✉

1. Department of Anatomy, Pusan National University School of Medicine, Yangsan 50612, Republic of Korea
2. PNU GRAND Convergence Medical Science Education Research Center, Pusan National University School of Medicine, Yangsan 50612, Republic of Korea

✉ Corresponding author: Changwan Hong, Department of Anatomy, Pusan National University School of Medicine Room 504, 49 Busandaehak-ro, Yangsan, Gyeongsangnam-do, 50612, South Korea. Tel: +82-51-510-8041; Fax.: +82-51-510 -8049; E-mail: chongac More

Citation:
Shim JA, Ryu JH, Jo Y, Hong C. The role of gut microbiota in T cell immunity and immune mediated disorders. Int J Biol Sci 2023; 19(4):1178-1191. doi:10.7150/ijbs.79430. https://www.ijbs.com/v19p1178.htm
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Abstract

Graphic abstract

Gut microbiota was only considered as a commensal organism that aids in digestion, but recent studies revealed that the microbiome play a critical role in both physiological and pathological immune system. The gut microbiome composition is altered by environmental factors such as diet and hygiene, and the alteration affects immune cells, especially T cells. Advanced genomic techniques in microbiome research defined that specific microbes regulate T cell responses and the pathogenesis of immune-mediated disorders. Here, we review features of specific microbes-T cell crosstalk and relationship between the microbes and immunopathogenesis of diseases including in cancers, autoimmune disorders and allergic inflammations. We also discuss the limitations of current experimental animal models, cutting-edge developments and current challenges to overcome in the field, and the possibility of considering gut microbiome in the development of new drug.

Keywords: microbiome, T cell, immune system, autoimmune disease, fecal microbiota transplant

Citation styles

APA
Shim, J.A., Ryu, J.H., Jo, Y., Hong, C. (2023). The role of gut microbiota in T cell immunity and immune mediated disorders. International Journal of Biological Sciences, 19(4), 1178-1191. https://doi.org/10.7150/ijbs.79430.

ACS
Shim, J.A.; Ryu, J.H.; Jo, Y.; Hong, C. The role of gut microbiota in T cell immunity and immune mediated disorders. Int. J. Biol. Sci. 2023, 19 (4), 1178-1191. DOI: 10.7150/ijbs.79430.

NLM
Shim JA, Ryu JH, Jo Y, Hong C. The role of gut microbiota in T cell immunity and immune mediated disorders. Int J Biol Sci 2023; 19(4):1178-1191. doi:10.7150/ijbs.79430. https://www.ijbs.com/v19p1178.htm

CSE
Shim JA, Ryu JH, Jo Y, Hong C. 2023. The role of gut microbiota in T cell immunity and immune mediated disorders. Int J Biol Sci. 19(4):1178-1191.

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