1. Department of Pharmacology, School of Pharmacy, Harbin Medical University, Harbin 150081, China 2. Department of Biomedical Engineering, Indiana University Purdue University Indianapolis, Indianapolis, IN 46202, USA 3. Indiana Center for Musculoskeletal Health, Indiana University School of Medicine, Indianapolis, IN 46202, USA 4. Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, IN 46202, USA
✉ Corresponding author: Hiroki Yokota, Ph.D., Department of Biomedical Engineering, Indiana University Purdue University Indianapolis, 723 West Michigan Street, SL220, Indianapolis, IN 46202 USA. Phone: 317-278-5177; Fax: 317-278-2455; Email: hyokotaedu. Bai-Yan Li, MD/Ph.D., Department of Pharmacology, School of Pharmacy, Harbin Medical University, #157 Baojian Road, Harbin 150081, China. Phone/Fax: +86 451-8667-1354; E-mail: libyhrbmu.edu.cn
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Citation:
Li K, Huo Q, Li BY, Yokota H. Three unconventional maxims in the natural selection of cancer cells: Generation of induced tumor-suppressing cells (iTSCs). Int J Biol Sci 2023; 19(5):1403-1412. doi:10.7150/ijbs.79155. https://www.ijbs.com/v19p1403.htm
Induced tumor-suppressing cells (iTSCs) can be generated from cancer and non-cancer cells. Here, three paradoxical maxims for the action of iTSCs are reviewed: the secretion of tumor-suppressing proteins, their role as a “double-edged” sword, and the elimination of lesser-fit cancer cells. “Super-fit” cancer cells secrete an array of proteins, most of which contribute to enhancing their growth and removing “lesser-fit” cancer cells. These maxims explain the potential dilemma with therapeutic agents since the inhibitory agents tend to promote the synthesis of tumor-promoting proteins. The maxims suggest the possibility of a novel treatment option using cancer-guided evolutionary-fit iTSCs.
Keywords: natural selection, tumor proteome, iTSCs, conditioned medium, protein cocktail
Citation styles
APA
Li, K., Huo, Q., Li, B.Y., Yokota, H. (2023). Three unconventional maxims in the natural selection of cancer cells: Generation of induced tumor-suppressing cells (iTSCs). International Journal of Biological Sciences, 19(5), 1403-1412. https://doi.org/10.7150/ijbs.79155.
ACS
Li, K.; Huo, Q.; Li, B.Y.; Yokota, H. Three unconventional maxims in the natural selection of cancer cells: Generation of induced tumor-suppressing cells (iTSCs). Int. J. Biol. Sci. 2023, 19 (5), 1403-1412. DOI: 10.7150/ijbs.79155.
NLM
Li K, Huo Q, Li BY, Yokota H. Three unconventional maxims in the natural selection of cancer cells: Generation of induced tumor-suppressing cells (iTSCs). Int J Biol Sci 2023; 19(5):1403-1412. doi:10.7150/ijbs.79155. https://www.ijbs.com/v19p1403.htm
CSE
Li K, Huo Q, Li BY, Yokota H. 2023. Three unconventional maxims in the natural selection of cancer cells: Generation of induced tumor-suppressing cells (iTSCs). Int J Biol Sci. 19(5):1403-1412.
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