Volume 21, Issue 5

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Volume 21 (5); 2025

Research Papers

Impact of Parental Time-Restricted Feeding on Offspring Metabolic Phenotypic Traits
Yibo Fan, Xiangyuan Peng, Nishat I. Tabassum, Xiangru Cheng, Sharmelee Selvaraji, Vivian Tran, Tayla A. Gibson Hughes, Buddhila Wickramasinghe, Abdulsatar Jamal, Quynh Nhu Dinh, Mathias Gelderblom, Grant R. Drummond, Christopher G. Sobey, Jim Penman, Terrance G. Johns, Raghu Vemuganti, Jayantha Gunaratne, Mark P. Mattson, Dong-Gyu Jo, Maria Jelinic, Thiruma V. Arumugam
Int. J. Biol. Sci. 2025; 21(5): 1852-1862. doi:10.7150/ijbs.107469
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Mitochondrial Localization and Function of Adenosine Receptors
Alejandro Sánchez-Melgar, Valentina Vultaggio-Poma, Simoneta Falzoni, Clara Fructuoso, José Luis Albasanz, Francesco Di Virgilio, Mairena Martín
Int. J. Biol. Sci. 2025; 21(5): 1874-1893. doi:10.7150/ijbs.101930
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Targeting ALG3/FOXD1/BNIP3 Axis Prevents Mitophagy and Gemcitabine Resistance of Nasopharyngeal Carcinoma
Zhanwang Wang, Yi Jin, Dong He, Yuxing Zhu, Mengqing Xiao, Xiaoming Liu, Yaxin Cheng, Ke Cao
Int. J. Biol. Sci. 2025; 21(5): 1894-1913. doi:10.7150/ijbs.101585
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BRD7 Inhibited Immune Escape in Nasopharyngeal Carcinoma via Inhibiting PD-L1 Expression
Yilin Guo, Jiaxue Lu, Xiaoxu Li, Shiqi Yan, Jieyu Zhou, Ziying Tian, Ying Liu, Nan Li, Qing Zhou, Xiayu Li, Lei Shi, Su Jiang, Mengna Li, Xiao Zhou, Donghai Huang, Zhaoyang Zeng, Songqing Fan, Wei Xiong, Ming Zhou, Guiyuan Li, Wenling Zhang
Int. J. Biol. Sci. 2025; 21(5): 1914-1931. doi:10.7150/ijbs.103703
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TMEM105 modulates disulfidptosis and tumor growth in pancreatic cancer via the β-catenin-c-MYC-GLUT1 axis
Yifan Yin, Yixuan Sun, Hongfei Yao, Feng Yu, Qinyuan Jia, Chengyu Hu, Yuheng Zhu, Zonghao Duan, Dejun Liu, Yongwei Sun, Yanmiao Huo, Minwei Yang, Wei Liu
Int. J. Biol. Sci. 2025; 21(5): 1932-1948. doi:10.7150/ijbs.104598
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BAP1 Represses Sequential Activation of IRAKs and NF-κB Signaling in Pancreatic Cancer
Yuhan Zhao, Xueyi Liang, Ruozheng Wei, Feng Guo, Gengdu Qin, Haixin Yu, Jiaying Liu, Wentao Xia, Shanmiao Gou, Heshui Wu, Yingke Zhou
Int. J. Biol. Sci. 2025; 21(5): 1949-1965. doi:10.7150/ijbs.104977
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Core transcriptional regulatory circuitry molecule ZNF217 promotes AML cell proliferation by up-regulating MYB
Bi Zhou, Fang Fang, YongPing Zhang, ZhiHeng Li, YiXin Hu, Yan Li, WanYan Jiao, YuMeng Wu, XiaoMei Wan, Ying Yang, FenLi Zhang, Ling Xu, TongTing Ji, Jian Pan, ShaoYan Hu
Int. J. Biol. Sci. 2025; 21(5): 1966-1983. doi:10.7150/ijbs.103211
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Inhibition of Cyclin D1 by Novel Biguanide Derivative YB-004 Increases the Sensitivity of Bladder Cancer to Olaparib via Causing G0 / G1 Arrest
Di Xiao, Xuetong Chu, Weifan Wang, Mei Peng, Qi Lv, Cangcang Xu, Huaxin Duan, Xiaoping Yang
Int. J. Biol. Sci. 2025; 21(5): 1984-1998. doi:10.7150/ijbs.105072
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Cyclin Y interacts with Chk1 to activate RRM2/STAT3 signaling and promotes radioresistance in non-small cell lung cancer
Zhiwei Liu, Huichan Xue, Zhi Wang, Ye Zhao, Shuangbing Xu, Xiaorong Dong
Int. J. Biol. Sci. 2025; 21(5): 1999-2011. doi:10.7150/ijbs.106925
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eNAMPT/Ac-STAT3/DIRAS2 Axis Promotes Development and Cancer Stemness in Triple-Negative Breast Cancer by Enhancing Cytokine Crosstalk Between Tumor-Associated Macrophages and Cancer Cells
Lifen Zhang, Lu Wang, Ziyao Xu, Xingmei Zhang, Shaoyu Guan, Zhe Liu, Shanzhi Gu, Lin Zhao, Weichao Bai, Tian Li, Xinhan Zhao
Int. J. Biol. Sci. 2025; 21(5): 2027-2047. doi:10.7150/ijbs.103723
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IGF2BP3 promotes the proliferation and cisplatin resistance of bladder cancer by enhancing the mRNA stability of CDK6 in an m6A dependent manner
Qiang Song, Wei Wang, Hao Yu, Zijian Zhou, Juntao Zhuang, Jiancheng Lv, Linjing Jiang, Xiao Yang, Qiang Lu, Haiwei Yang
Int. J. Biol. Sci. 2025; 21(5): 2048-2066. doi:10.7150/ijbs.103522
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Contact Cooling-Induced ELOVL4 Enhances Skin Wound Healing by Promoting the Inflammation-to-Proliferation Phase Transition
Siyi Zhou, Zeming Li, Ke Li, Yuanli Ye, Huan Liang, Nian'Ou Wang, Weiwei Liu, Jingwei Jiang, Martin Y M Chiang, Aijun Chen, Xiao Xiang, Mingxing Lei
Int. J. Biol. Sci. 2025; 21(5): 2067-2082. doi:10.7150/ijbs.107871
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Thrombospondin 1 Promotes Cytoskeleton Remodeling, Dedifferentiation, and Pulmonary Metastasis through ITGA1 and ITGA6 in Osteosarcoma
Enjie Xu, Zhen Huang, Kunpeng Zhu, Jianping Hu, Xiaolong Ma, Yongjie Wang, Jiazhuang Zhu, Chunlin Zhang
Int. J. Biol. Sci. 2025; 21(5): 2083-2100. doi:10.7150/ijbs.93678
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Accelerating Ligand Discovery for Insect Odorant Receptors
Arthur Comte, Maxence Lalis, Ludvine Brajon, Riccardo Moracci, Nicolas Montagné, Jérémie Topin, Emmanuelle Jacquin Joly, Sébastien Fiorucci
Int. J. Biol. Sci. 2025; 21(5): 2101-2117. doi:10.7150/ijbs.105648
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YBX1/CD36 positive feedback loop-mediated lipid accumulation drives metabolic dysfunction-associated steatotic liver disease
Qingqing Zhang, Fei Li, Qichao Ge, Yihui Wang, Zhenyang Shen, Yuecheng Guo, Junjun Wang, Hanjing Zhangdi, Jingyi Lu, Jiaqi Gao, Guangwen Chen, Qidi Zhang, Xingpeng Wang, Hui Dong, Lungen Lu
Int. J. Biol. Sci. 2025; 21(5): 2118-2134. doi:10.7150/ijbs.105798
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FAT1 functions as an oncogenic driver in triple negative breast cancer through AKT pathway-driven effects on the matrisome
Panpan Zhao, Yuanyuan Zhang, Yang Yu, Qing Zhang, Xiaoying Liu, Xu Dong Zhang, Song Chen, Charles E. de Bock, Rick F. Thorne, Yujie Shi
Int. J. Biol. Sci. 2025; 21(5): 2201-2222. doi:10.7150/ijbs.104921
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PSMC6 regulation of ovarian cancer cisplatin resistance unravels a new mode for proteasome targeting
Matteo Costantino, Luca Mirra, Padraig D'arcy, Cristina Corno, Nives Carenini, Elisabetta Corna, Johannes Gubat, Chiara M. Ciniselli, Pietro Pratesi, Paolo Verderio, Stig Linder, Giovanni L. Beretta, Paola Perego
Int. J. Biol. Sci. 2025; 21(5): 2258-2274. doi:10.7150/ijbs.104612
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OLFML3 Promotes IRG1 Mitochondrial Localization and Modulates Mitochondrial Function in Macrophages
Qijun Yu, Hong Mei, Qian Gu, Ran Zeng, Yanan Li, Junjie Zhang, Chenxu Gao, Hai Fang, Jieming Qu, Jia Liu
Int. J. Biol. Sci. 2025; 21(5): 2275-2295. doi:10.7150/ijbs.103859
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Identification of the LCOR-PLCL1 pathway that restrains lipid accumulation and tumor progression in clear cell renal cell carcinoma
Wen Li, Jian Shi, Qingyang Lv, Daojia Miao, Diaoyi Tan, Xiaojun Lu, Hairong Xiong, Qianqian Luo, Yaru Xia, Yuqi Han, Xuejiao Dong, Guixiao Huang, Xiaoping Zhang, Hongmei Yang
Int. J. Biol. Sci. 2025; 21(5): 2296-2312. doi:10.7150/ijbs.107981
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Remote Ischemic Preconditioning Attenuates Mitochondrial Dysfunction and Ferroptosis of Tubular Epithelial Cells by Inhibiting NOX4-ROS Signaling in Acute Kidney Injury
Wei Wei, Letian Yang, Bo Wang, Lei Tang, Jian Li, Caihong Liu, Yongxiu Huang, Zhuyun Zhang, Dingkun Zhang, Ling Zhang, Liang Ma, Ping Fu, Yuliang Zhao
Int. J. Biol. Sci. 2025; 21(5): 2313-2329. doi:10.7150/ijbs.105667
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Dysregulation of N-glycosylation by Rpn1 knockout in spermatocytes induces male infertility via endoplasmic reticulum stress in mice
Mingyu Zhang, Mengjing Li, Hanzhen Li, Yanling Wan, Shuang Yang, Shuhui Ji, Haobo Zhang, Chao Liu, Gang Lu, Xiaohua Jiang, Hongbin Liu
Int. J. Biol. Sci. 2025; 21(5): 2360-2379. doi:10.7150/ijbs.106468
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Reviews

Fatty Acid Trafficking Between Lipid Droplets and Mitochondria: An Emerging Perspective
Katarína Smolková, Klára Gotvaldová
Int. J. Biol. Sci. 2025; 21(5): 1863-1873. doi:10.7150/ijbs.105361
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Regulated Cell Death in Lenvatinib Resistance of Hepatocellular Carcinoma: from Molecular Mechanisms to Therapeutic Strategies
Ronggao Chen, Xin Hu, Yingchen Huang, Yao Jiang, Guanrong Chen, Qiaonan Shan, Xiao Xu, Shusen Zheng
Int. J. Biol. Sci. 2025; 21(5): 2012-2026. doi:10.7150/ijbs.107195
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Molecular Mechanisms of Ischemia/Reperfusion Injury and Graft Dysfunction in Liver Transplantation: Insights from Multi-Omics Studies in Rodent Animal Models
Zhengtao Liu, Jun Xu, Ting Que, Shuping Que, Luca Valenti, Shusen Zheng
Int. J. Biol. Sci. 2025; 21(5): 2135-2154. doi:10.7150/ijbs.109449
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What is the Impact of Endothelial-to-Mesenchymal Transition in Solid Tumours: A Qualitative Systematic Review and Quantitative Meta-Analysis
Pablo Hernández-Camarero, Belén Toledo, Ana Belén Diaz-Ruano, Aitor González-Titos, María Belén García-Ortega, Macarena Perán
Int. J. Biol. Sci. 2025; 21(5): 2155-2178. doi:10.7150/ijbs.107045
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Mitochondrial Regulation of Ferroptosis in Cancer Cells
Zilin Ding, Zhiyu Li, Kai Sun, Yi Liu, Zhou Fang, Shengrong Sun, Chenyuan Li, Zhong Wang
Int. J. Biol. Sci. 2025; 21(5): 2179-2200. doi:10.7150/ijbs.105446
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Neutrophils in tumor- and inflammation-induced lymphangiogenesis
Xinyu Li, Xiaoxin Liu, Haotian Wei, Yanyan Liu, Gang Xu
Int. J. Biol. Sci. 2025; 21(5): 2223-2234. doi:10.7150/ijbs.103458
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Harnessing Macrophages in Cancer Therapy: from Immune Modulators to Therapeutic Targets
Huabing Tan, Meihe Cai, Jincheng Wang, Tao Yu, Houjun Xia, Huanbin Zhao, Xiaoyu Zhang
Int. J. Biol. Sci. 2025; 21(5): 2235-2257. doi:10.7150/ijbs.106275
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Functions and Clinical Applications of Exosomes in Gastric Cancer
Zhi Zheng, Yuhao Zhai, Xiaosheng Yan, Zimeng Wang, Haiqiao Zhang, Rui Xu, Xiaoye Liu, Jun Cai, Zhongtao Zhang, Yuxi Shang, Jun Zhang, Jie Yin
Int. J. Biol. Sci. 2025; 21(5): 2330-2345. doi:10.7150/ijbs.98087
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The Role of Thrombospondins in Osteoarthritis: from Molecular Mechanisms to Therapeutic Potential
Yirixiati Aihaiti, Hui Yu, Peng Xu
Int. J. Biol. Sci. 2025; 21(5): 2346-2359. doi:10.7150/ijbs.103343
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