Int J Biol Sci 2020; 16(2):264-271. doi:10.7150/ijbs.38143

Review

Hydrogen Sulfide Plays an Important Protective Role through Influencing Endoplasmic Reticulum Stress in Diseases

Honggang Wang1✉, Xingzhuo Shi2, Mengyuan Qiu1, Shuangyu Lv1, Huiyang Liu1

1. Institute of Biomedical Informatics, Bioinformatics Center, School of Basic Medical Sciences, Henan University, Kaifeng, Henan, 475000, China.
2. School of Life Science, Henan University, Kaifeng, Henan, 475000, China.

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Citation:
Wang H, Shi X, Qiu M, Lv S, Liu H. Hydrogen Sulfide Plays an Important Protective Role through Influencing Endoplasmic Reticulum Stress in Diseases. Int J Biol Sci 2020; 16(2):264-271. doi:10.7150/ijbs.38143. Available from http://www.ijbs.com/v16p0264.htm

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Abstract

The endoplasmic reticulum is an important organelle responsible for protein synthesis, modification, folding, assembly and transport of new peptide chains. When the endoplasmic reticulum protein folding ability is impaired, the unfolded or misfolded proteins accumulate to lead to endoplasmic reticulum stress. Hydrogen sulfide is an important signaling molecule that regulates many physiological and pathological processes. Recent studies indicate that H2S plays an important protective role in many diseases through influencing endoplasmic reticulum stress, but its mechanism is not fully understood. This article reviewed the progress about the effect of H2S on endoplasmic reticulum stress and its mechanisms involved in diseases in recent years to provide theoretical basis for in-depth study.

Keywords: Hydrogen sulfide, endoplasmic reticulum stress, cardiomyopathy, neurological diseases, respiratory diseases, vascular diseases