Int J Biol Sci
2020; 16(9):1575-1585.
doi:10.7150/ijbs.41852 This issueCite
Review
STAT4: an immunoregulator contributing to diverse human diseases
Chou Yang, Haoming Mai, Jinxin Peng, Bin Zhou, Jinlin Hou, Deke Jiang✉
State Key Laboratory of Organ Failure Research, Guangdong Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases and Hepatology Unit, Nanfang Hospital, Southern Medical University, GuangZhou, China.
✉ Corresponding author: Deke Jiang, PhD, Department of Infectious Diseases and Hepatology Unit, Nanfang Hospital, Southern Medical University, GuangZhou 510515, China. Phone: (86) 20-62786533; Email: dekejiang17edu.cn
Citation:
Yang C, Mai H, Peng J, Zhou B, Hou J, Jiang D. STAT4: an immunoregulator contributing to diverse human diseases. Int J Biol Sci 2020; 16(9):1575-1585. doi:10.7150/ijbs.41852. https://www.ijbs.com/v16p1575.htm
Signal transducer and activator of transcription 4 (STAT4) is a member of the STAT family and localizes to the cytoplasm. STAT4 is phosphorylated after a variety of cytokines bind to the membrane, and then dimerized STAT4 translocates to the nucleus to regulate gene expression. We reviewed the essential role played by STAT4 in a wide variety of cells and the pathogenesis of diverse human diseases, especially many kinds of autoimmune and inflammatory diseases, via activation by different cytokines through the Janus kinase (JAK)-STAT signaling pathway.
Citation styles
APA
Yang, C., Mai, H., Peng, J., Zhou, B., Hou, J., Jiang, D. (2020). STAT4: an immunoregulator contributing to diverse human diseases. International Journal of Biological Sciences, 16(9), 1575-1585. https://doi.org/10.7150/ijbs.41852.
ACS
Yang, C.; Mai, H.; Peng, J.; Zhou, B.; Hou, J.; Jiang, D. STAT4: an immunoregulator contributing to diverse human diseases. Int. J. Biol. Sci. 2020, 16 (9), 1575-1585. DOI: 10.7150/ijbs.41852.
NLM
Yang C, Mai H, Peng J, Zhou B, Hou J, Jiang D. STAT4: an immunoregulator contributing to diverse human diseases. Int J Biol Sci 2020; 16(9):1575-1585. doi:10.7150/ijbs.41852. https://www.ijbs.com/v16p1575.htm
CSE
Yang C, Mai H, Peng J, Zhou B, Hou J, Jiang D. 2020. STAT4: an immunoregulator contributing to diverse human diseases. Int J Biol Sci. 16(9):1575-1585.
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