Int J Biol Sci 2022; 18(3):1065-1078. doi:10.7150/ijbs.68591 This issue Cite

Review

Calcium and calcium-related proteins in endometrial cancer: opportunities for pharmacological intervention

Ting Huang, Jingyi Zhou, Jianliu Wang

Department of Obstetrics and Gynecology, Peking University People's Hospital, Beijing 100044, P.R. China.

Citation:
Huang T, Zhou J, Wang J. Calcium and calcium-related proteins in endometrial cancer: opportunities for pharmacological intervention. Int J Biol Sci 2022; 18(3):1065-1078. doi:10.7150/ijbs.68591. https://www.ijbs.com/v18p1065.htm
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Abstract

Graphic abstract

Intracellular calcium ions are key second messengers and play an important role in malignant transformation and cancer progression. Estrogen can evoke intracellular calcium increases through membrane-initiated effects and activate subsequent kinase cascades within minutes in normal and cancerous epithelial cells. Ca2+-related proteins are expressed in normal epithelial cells or endometrial cancer cells, some of which are upregulated by estrogen. Both estrogen-induced transient calcium increases and long-term changes in protein expression levels may be involved in regulating cancer initiation, progression and metastasis. Calcium channel blockers are reported to regulate both the rapid estrogen-induced intracellular Ca2+ increase and cell proliferation, apoptosis and migration, thus having the potential for pharmacological modulators to be repurposed for the treatment of endometrial cancer.

Keywords: Endometrial cancer, Calcium, Estrogen, Calcium channel blocker


Citation styles

APA
Huang, T., Zhou, J., Wang, J. (2022). Calcium and calcium-related proteins in endometrial cancer: opportunities for pharmacological intervention. International Journal of Biological Sciences, 18(3), 1065-1078. https://doi.org/10.7150/ijbs.68591.

ACS
Huang, T.; Zhou, J.; Wang, J. Calcium and calcium-related proteins in endometrial cancer: opportunities for pharmacological intervention. Int. J. Biol. Sci. 2022, 18 (3), 1065-1078. DOI: 10.7150/ijbs.68591.

NLM
Huang T, Zhou J, Wang J. Calcium and calcium-related proteins in endometrial cancer: opportunities for pharmacological intervention. Int J Biol Sci 2022; 18(3):1065-1078. doi:10.7150/ijbs.68591. https://www.ijbs.com/v18p1065.htm

CSE
Huang T, Zhou J, Wang J. 2022. Calcium and calcium-related proteins in endometrial cancer: opportunities for pharmacological intervention. Int J Biol Sci. 18(3):1065-1078.

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