Int J Biol Sci
2022; 18(3):1065-1078.
doi:10.7150/ijbs.68591 This issueCite
Review
Calcium and calcium-related proteins in endometrial cancer: opportunities for pharmacological intervention
Ting Huang, Jingyi Zhou✉, Jianliu Wang✉
Department of Obstetrics and Gynecology, Peking University People's Hospital, Beijing 100044, P.R. China.
✉ Corresponding authors: Jianliu Wang, MD, Department of Gynecology and Obstetrics, Peking University People's Hospital, Beijing, China; Tel: 86-10-88324278; E-mail address: wangjianliuedu.cn; Jingyi Zhou, PhD, Department of Gynecology and Obstetrics, Peking University People's Hospital, Beijing, China; Phone: +86 15210829207; E-mail address: sy_zhoujingyipku.edu.cn.More
Citation:
Huang T, Zhou J, Wang J. Calcium and calcium-related proteins in endometrial cancer: opportunities for pharmacological intervention. Int J Biol Sci 2022; 18(3):1065-1078. doi:10.7150/ijbs.68591. https://www.ijbs.com/v18p1065.htm
Intracellular calcium ions are key second messengers and play an important role in malignant transformation and cancer progression. Estrogen can evoke intracellular calcium increases through membrane-initiated effects and activate subsequent kinase cascades within minutes in normal and cancerous epithelial cells. Ca2+-related proteins are expressed in normal epithelial cells or endometrial cancer cells, some of which are upregulated by estrogen. Both estrogen-induced transient calcium increases and long-term changes in protein expression levels may be involved in regulating cancer initiation, progression and metastasis. Calcium channel blockers are reported to regulate both the rapid estrogen-induced intracellular Ca2+ increase and cell proliferation, apoptosis and migration, thus having the potential for pharmacological modulators to be repurposed for the treatment of endometrial cancer.
Huang, T., Zhou, J., Wang, J. (2022). Calcium and calcium-related proteins in endometrial cancer: opportunities for pharmacological intervention. International Journal of Biological Sciences, 18(3), 1065-1078. https://doi.org/10.7150/ijbs.68591.
ACS
Huang, T.; Zhou, J.; Wang, J. Calcium and calcium-related proteins in endometrial cancer: opportunities for pharmacological intervention. Int. J. Biol. Sci. 2022, 18 (3), 1065-1078. DOI: 10.7150/ijbs.68591.
NLM
Huang T, Zhou J, Wang J. Calcium and calcium-related proteins in endometrial cancer: opportunities for pharmacological intervention. Int J Biol Sci 2022; 18(3):1065-1078. doi:10.7150/ijbs.68591. https://www.ijbs.com/v18p1065.htm
CSE
Huang T, Zhou J, Wang J. 2022. Calcium and calcium-related proteins in endometrial cancer: opportunities for pharmacological intervention. Int J Biol Sci. 18(3):1065-1078.
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