Department of Ophthalmology, The Second Hospital of Jilin University, Jilin University, Changchun, China
✉ Corresponding author: Yajuan Zheng, Department of Ophthalmology, The Second Hospital of Jilin University, Jilin University, 218 Ziqiang Street, Changchun, Jilin 130041, China. E-mail: yjzhengedu.cn
Citation:
Li Y, Zhao J, Yin Y, Li K, Zhang C, Zheng Y. The Role of IL-6 in Fibrotic Diseases: Molecular and Cellular Mechanisms. Int J Biol Sci 2022; 18(14):5405-5414. doi:10.7150/ijbs.75876. https://www.ijbs.com/v18p5405.htm
Fibrosis is a detrimental outcome of most chronic inflammatory disorders and is defined by the buildup of excess extracellular matrix (ECM) components, which eventually leads to organ failure and death. Interleukin 6 (IL-6) is promptly produced by immune cells in response to tissue injuries and has a wide range of effects on cellular processes such as acute responses, hematopoiesis, and immune reactions. Furthermore, high levels of IL-6 have been found in a variety of chronic inflammatory disorders characterized by fibrosis, and this factor plays a significant role in fibrosis in various organs via Janus kinase/signal transducer and activator of transcription 3 (JAK/STAT3) activation. Here, we review what is known about the role of IL-6 in fibrosis and why targeting IL-6 for fibrotic disease treatment makes sense.
Keywords: Interleukin 6, JAK, STAT3, fibrosis
Citation styles
APA
Li, Y., Zhao, J., Yin, Y., Li, K., Zhang, C., Zheng, Y. (2022). The Role of IL-6 in Fibrotic Diseases: Molecular and Cellular Mechanisms. International Journal of Biological Sciences, 18(14), 5405-5414. https://doi.org/10.7150/ijbs.75876.
ACS
Li, Y.; Zhao, J.; Yin, Y.; Li, K.; Zhang, C.; Zheng, Y. The Role of IL-6 in Fibrotic Diseases: Molecular and Cellular Mechanisms. Int. J. Biol. Sci. 2022, 18 (14), 5405-5414. DOI: 10.7150/ijbs.75876.
NLM
Li Y, Zhao J, Yin Y, Li K, Zhang C, Zheng Y. The Role of IL-6 in Fibrotic Diseases: Molecular and Cellular Mechanisms. Int J Biol Sci 2022; 18(14):5405-5414. doi:10.7150/ijbs.75876. https://www.ijbs.com/v18p5405.htm
CSE
Li Y, Zhao J, Yin Y, Li K, Zhang C, Zheng Y. 2022. The Role of IL-6 in Fibrotic Diseases: Molecular and Cellular Mechanisms. Int J Biol Sci. 18(14):5405-5414.
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