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Volume 20 (12); 2024

Research Papers

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Dissection of Targeting Molecular Mechanisms of Celastrol-induced Nephrotoxicity via A Combined Deconvolution Strategy of Chemoproteomics and Metabolomics
Xueying Liu, Qian Zhang, Peili Wang, Xin Peng, Yehai An, Junhui Chen, Jingnan Huang, Shuanglin Qin, Hengkai He, Mingjing Hao, Jiahang Tian, Letai Yi, Ming Lei, Piao Luo, Jigang Wang, Xinzhou Zhang
Int. J. Biol. Sci. 2024; 20(12): 4601-4617. doi:10.7150/ijbs.91751
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SIX4 Activation in Inflammatory Response Drives the Transformation of Colorectal Epithelium into Inflammation and Tumor via Feedback-Enhancing Inflammatory Signaling to Induce Tumor Stemness Signaling
Ziyan Zhang, Huang Huang, Lanzhu Peng, Beixian Zhou, Huiling Yang, Zibo Tang, Weiwei Yan, Weifeng Chen, Zhen Liu, Dayong Zheng, Peng Shen, Weiyi Fang
Int. J. Biol. Sci. 2024; 20(12): 4618-4634. doi:10.7150/ijbs.93411
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Darolutamide-mediated phospholipid remodeling induces ferroptosis through the SREBP1-FASN axis in prostate cancer
Bingheng Li, Bisheng Cheng, Hao Huang, Shanhe Huang, Shunli Yu, Zean Li, Shirong Peng, Tao Du, Ruihui Xie, Hai Huang
Int. J. Biol. Sci. 2024; 20(12): 4635-4653. doi:10.7150/ijbs.101039
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MicroRNA-29b Plays a Vital Role in Podocyte Injury and Glomerular Diseases through Inducing Mitochondrial Dysfunction
Jiafeng Liu, Yabing Xiong, Hongyan Mo, Hongxin Niu, Jinhua Miao, Weiwei Shen, Shan Zhou, Xiaoxu Wang, Xiaolong Li, Yunfang Zhang, Kunling Ma, Lili Zhou
Int. J. Biol. Sci. 2024; 20(12): 4654-4673. doi:10.7150/ijbs.93506
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Genome-wide binding analysis unveils critical implication of B-Myb-mediated transactivation in cancers
Chuntao Tao, Tao Liu, Zongrong Zhao, Xuanqi Dou, Xing Xia, Kailong Du, Xiaofeng Zuo, Yitao Wang, Tingting Wang, Youquan Bu
Int. J. Biol. Sci. 2024; 20(12): 4691-4712. doi:10.7150/ijbs.92607
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Neutrophil extracellular traps trigger alveolar epithelial cell necroptosis through the cGAS-STING pathway during acute lung injury in mice
Han-Xi Sha, Yu-Biao Liu, Yan-Ling Qiu, Wen-Jing Zhong, Nan-Shi-Yu Yang, Chen-Yu Zhang, Jia-Xi Duan, Jian-Bing Xiong, Cha-Xiang Guan, Yong Zhou
Int. J. Biol. Sci. 2024; 20(12): 4713-4730. doi:10.7150/ijbs.99456
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METTL18 functions as a Phenotypic Regulator in Src-Dependent Oncogenic Responses of HER2-Negative Breast Cancer
Han Gyung Kim, Ji Hye Kim, Kyung-Hee Kim, Byong Chul Yoo, Sung-Ung Kang, Young Bong Kim, Sangmin Kim, Hyun-June Paik, Jeong Eon Lee, Seok Jin Nam, Narayanan Parameswaran, Jeung-Whan Han, Balachandran Manavalan, Jae Youl Cho
Int. J. Biol. Sci. 2024; 20(12): 4731-4749. doi:10.7150/ijbs.96487
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Targeting METTL3 enhances the chemosensitivity of non-small cell lung cancer cells by decreasing ABCC2 expression in an m6A-YTHDF1-dependent manner
Rui Zhang, Pu Chen, Yubo Wang, Zekun Zeng, Huini Yang, Mengdan Li, Xi Liu, Wei Yu, Peng Hou
Int. J. Biol. Sci. 2024; 20(12): 4750-4766. doi:10.7150/ijbs.97425
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NUCB2 promotes hepatocellular carcinoma cell growth and metastasis by activating the E2F4/PTGR1 axis
Yuan Wang, Bin Sun, Wei Wei, Tao Han, Jing Ma, Xiaodong Li, Chuanchun Han, Zhikun Lin
Int. J. Biol. Sci. 2024; 20(12): 4767-4780. doi:10.7150/ijbs.97861
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ESM1 facilitates the EGFR/HER3-triggered epithelial-to-mesenchymal transition and progression of gastric cancer via modulating interplay between Akt and angiopoietin-2 signaling
Yi-Chieh Yang, Ko-Hao Ho, Ke-Fan Pan, Kuo-Tai Hua, Min-Che Tung, Chia-Chi Ku, Ji-Qing Chen, Michael Hsiao, Chi-Long Chen, Wei-Jiunn Lee, Ming-Hsien Chien
Int. J. Biol. Sci. 2024; 20(12): 4819-4837. doi:10.7150/ijbs.100276
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NOP2-mediated 5-methylcytosine modification of APOL1 messenger RNA activates PI3K-Akt and facilitates clear cell renal cell carcinoma progression
Junjie Tian, Jianguo Gao, Cheng Cheng, Zhijie Xu, Xiaoyi Chen, Yunfei Wu, Guanghou Fu, Baiye Jin
Int. J. Biol. Sci. 2024; 20(12): 4853-4871. doi:10.7150/ijbs.97503
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METTL3-mediated m6A modification of OTUD1 aggravates press overload induced myocardial hypertrophy by deubiquitinating PGAM5
Kai Huang, Xiaotian Sun, Xiangyang Xu, Jie Lu, Boyao Zhang, Qin Li, Chuyi Wang, Sufan Ding, Xiaolei Huang, Xiaohong Liu, Zhiyun Xu, Lin Han
Int. J. Biol. Sci. 2024; 20(12): 4908-4921. doi:10.7150/ijbs.95707
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Pharmacological manipulation of TRPC5 by kaempferol attenuates metastasis of gastrointestinal cancer via inhibiting calcium involved in the formation of filopodia
Suyun Yu, Rui Deng, Wei Wang, Defang Zou, Liang He, Zhonghong Wei, Yanhong Pan, Xiaoman Li, Yuanyuan Wu, Aiyun Wang, Wenxing Chen, Yang Zhao, Yin Lu
Int. J. Biol. Sci. 2024; 20(12): 4922-4940. doi:10.7150/ijbs.87829
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Serum amyloid A contributes to radiation-induced lung injury by activating macrophages through FPR2/Rac1/NF-κB pathway
Xinglong Liu, Yimeng Song, Songling Hu, Yang Bai, Jianghong Zhang, Guomei Tai, Chunlin Shao, Yan Pan
Int. J. Biol. Sci. 2024; 20(12): 4941-4956. doi:10.7150/ijbs.100823
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NDR1/FBXO11 promotes phosphorylation-mediated ubiquitination of β-catenin to suppress metastasis in prostate cancer
Zuodong Xuan, Chen Chen, Huimin Sun, Kunao Yang, Jinxin Li, Meilin Fu, Yang Bai, Zeyuan Zheng, Yue Zhao, Chunlan Xu, Bin Liu, Tian Li, Chen Shao
Int. J. Biol. Sci. 2024; 20(12): 4957-4977. doi:10.7150/ijbs.98907
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Transcription Factor E2F4 Promote Proliferation, Migration, and Invasion of Gastric Cancer Cells by transcriptionally activating DSCC1
Shantanu Baral, Yantao Yu, Qiannan Sun, Mingrui Jiang, Ruiqi Li, Yifan Cheng, Arawker Mubeen Hussein, Youquan Shi, Yongjun Jiang, Dong Tang, Sen Wang, Daorong Wang
Int. J. Biol. Sci. 2024; 20(12): 4978-4998. doi:10.7150/ijbs.99590
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RUNX1-MUC13 Interaction Activates Wnt/β-Catenin Signaling Implications for Colorectal Cancer Metastasis
Xinyi Chen, Jingyao Tu, Mu Yang, Yuan Wang, Bo Liu, Hong Qiu, Xianglin Yuan
Int. J. Biol. Sci. 2024; 20(12): 4999-5026. doi:10.7150/ijbs.98396
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Reviews

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Versatility of the Zinc-Finger Antiviral Protein (ZAP) As a Modulator of Viral Infections
Ran Shao, Imke Visser, Jelke J. Fros, Xin Yin
Int. J. Biol. Sci. 2024; 20(12): 4585-4600. doi:10.7150/ijbs.98029
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Targeting ferroptosis opens new avenues in gliomas
Yuxin Wei, Yang Xu, Qian Sun, Yu Hong, Shanwen Liang, Hongxiang Jiang, Xinyi Zhang, Shenqi Zhang, Qianxue Chen
Int. J. Biol. Sci. 2024; 20(12): 4674-4690. doi:10.7150/ijbs.96476
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Mechanisms of hepatic and renal injury in lipid metabolism disorders in metabolic syndrome
Jin Rong, Zixuan Zhang, Xiaoyu Peng, Ping Li, Tingting Zhao, Yifei Zhong
Int. J. Biol. Sci. 2024; 20(12): 4783-4798. doi:10.7150/ijbs.100394
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Bridging Chronic Inflammation and Digestive Cancer: The Critical Role of Innate Lymphoid Cells in Tumor Microenvironments
Guanliang Shen, Qi Wang, Zhengrui Li, Jiaheng Xie, Xinda Han, Zehao Wei, Pengpeng Zhang, Songyun Zhao, Xiumei Wang, Xufeng Huang, Min Xu
Int. J. Biol. Sci. 2024; 20(12): 4799-4818. doi:10.7150/ijbs.96338
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Potential Roles and Mechanisms of Curcumin and its Derivatives in the Regulation of Ferroptosis
Yuan Zhang, Chenghao Yu, Cheng Peng, Fu Peng
Int. J. Biol. Sci. 2024; 20(12): 4838-4852. doi:10.7150/ijbs.90798
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Elucidating the evolving role of cuproptosis in breast cancer progression
Zhanyong Zhu, Keyu Zhu, Jun Zhang, Yunhua Zhou, Qi Zhang
Int. J. Biol. Sci. 2024; 20(12): 4872-4887. doi:10.7150/ijbs.98806
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Antioxidant genes in cancer and metabolic diseases: Focusing on Nrf2, Sestrin, and heme oxygenase 1
Jitendra Shrestha, Khem Raj Limbu, Rashmi Bhandari Chhetri, Keshav Raj Paudel, Philip M. Hansbro, Yoon Sin Oh, Dong Jae Baek, Sung-Hwan Ki, Eun-Young Park
Int. J. Biol. Sci. 2024; 20(12): 4888-4907. doi:10.7150/ijbs.98846
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Erratum

Triptolide Suppresses Glomerular Mesangial Cell Proliferation in Diabetic Nephropathy Is Associated with Inhibition of PDK1/Akt/mTOR Pathway: Erratum
Fei Han, Mei Xue, Yunpeng Chang, Xiaoyu Li, Yang Yang, Bei Sun, Liming Chen
Int. J. Biol. Sci. 2024; 20(12): 4781-4782. doi:10.7150/ijbs.101944
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