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Volume 21 (7); 2025

Editorial

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Is it time for exercise-conditioned plasma to enter human trials?
Patrick Henry Sebastian Sitjar, Jorming Goh
Int. J. Biol. Sci. 2025; 21(7): 2954-2956. doi:10.7150/ijbs.110586
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Research Papers

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De-succinylation-induced accumulation of TRMT10C in the nucleus plays a detrimental role in coronary microembolization via its m1A modification function
Chen-Kai Hu, Wan-Zhong Huang, Lei He, Chen Chang, Yan-Ling Ren, Ri-Xin Dai, Qiang Wu, Qiang Su
Int. J. Biol. Sci. 2025; 21(7): 2891-2920. doi:10.7150/ijbs.107965
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SLC25A33-mediated mitochondrial DNA synthesis plays a critical role in the inflammatory response of M1 macrophages by contributing to mitochondrial ROS and VDAC oligomerization
Daehoon Kim, Jonghwa Jin, Yu-Rim Lee, Dong-Ho Kim, Soo-Young Park, Jun-Kyu Byun, Yeon-Kyung Choi, Keun-Gyu Park
Int. J. Biol. Sci. 2025; 21(7): 2935-2953. doi:10.7150/ijbs.96563
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Pharmacological Activation of AMP-activated Protein Kinase Ameliorates Liver Fibrosis in a Metabolic Dysfunction-Associated Steatohepatitis Mouse Model
Seojeong Kim, Jae-Ho Shin, Minjung Seo, Eun Seon Pak, Kyung-Hwa Jeon, Inhye Moon, Jisoo Kang, Wonhyo Seo, Younghwa Na, Youngjoo Kwon
Int. J. Biol. Sci. 2025; 21(7): 2957-2972. doi:10.7150/ijbs.108731
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SIRT4 Controls Acetyl-CoA Synthesis to Promote Stemness and Invasiveness of Hepatocellular Carcinoma through Deacetylating MCCC2
Tianjiao Sun, Congcong Xu, Qingru Song, Xiaodan Yang, Guo An, Guogui Sun, Zhiqian Zhang
Int. J. Biol. Sci. 2025; 21(7): 2973-2990. doi:10.7150/ijbs.99004
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SIRT3 is required for the protective function of ketogenic diet on neural inflammation and neuropathic pain
Mengqiu Deng, Yuanyuan Fang, Yan Chu, Ruifeng Ding, Xiaoyi Fan, Huawei Wei, Honghao Song, Guowei Jiang, Hailing Zhang, Chaofeng Han, Hongbin Yuan
Int. J. Biol. Sci. 2025; 21(7): 3011-3029. doi:10.7150/ijbs.110921
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Theaflavins attenuate iron overload-induced liver oxidative injury by inhibiting hepatocyte ferroptosis
Junzhou Chen, Mingdao Mu, Xin Lai, Chen Liu, Yuheng Luo, Jun He, Bing Yu, Quyuan Wang, Huifen Wang, Daiwen Chen, Aimin Wu
Int. J. Biol. Sci. 2025; 21(7): 3030-3044. doi:10.7150/ijbs.103971
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The Therapeutic Potential of EGCG and Pro-EGCG in Mitigating Ovarian Hyperstimulation Syndrome: Unraveling the Modulatory Mechanism through the VEGF Pathway
Sijia Wang, Lanlan Fang, Luping Cong, Qiongqiong Jia, Waner Wu, Mingpeng Zhao, Tinchiu Li, Jacqueline Pui Wah Chung, Ka Kei Fung, Vivian Ching Man Lam, Yingpu Sun, Jung-Chien Cheng, David Yiu Leung Chan
Int. J. Biol. Sci. 2025; 21(7): 3045-3060. doi:10.7150/ijbs.98653
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Macrophage-derived S100A9 promotes diabetic cardiomyopathy by disturbing mitochondrial quality control via STAT3 activation
Shengqi Huo, Moran Wang, Min Du, Bowen Ren, Tianshu Yang, Lulu Peng, Yue Jiang, Dewei Peng, Lintong Men, Wei Shi, Junyi Guo, Cuntai Zhang, Jiagao Lv, Sheng Li, Li Lin
Int. J. Biol. Sci. 2025; 21(7): 3061-3080. doi:10.7150/ijbs.111128
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Modulating the Immunosuppressive Tumor Microenvironment and Inhibiting Growth in Mutp53-Driven CRPC via STAT3 Pathway Blockade
Zichen Bian, Jia Chen, Yufan Wang, Chen Jin, Chaozhao Liang, Jialin Meng, Meng Zhang
Int. J. Biol. Sci. 2025; 21(7): 3081-3098. doi:10.7150/ijbs.111732
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Regulating the balance between GSDMD-mediated pyroptosis and CHMP4B-dependent cell repair attenuates calcium oxalate kidney stone formation
Shushuai Yang, Yuanjiong Qi, Yue Chen, Hailong Kong, Bin Han, Zhongsheng Peng, Chenglong Xu, Bohan Wang, Liqun Chen, Shiyong Qi
Int. J. Biol. Sci. 2025; 21(7): 3099-3121. doi:10.7150/ijbs.105415
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VRK1/BANF1/GLI1 Axis Regulates Tumor Development and Progression of Colorectal Cancer
Xu Wang, Yuanmin Xu, Shixin Chan, Hu Zhao, Siwei Huang, Yiming Wang, Yang Yang, Zhenglin Wang, Xiaomin Zuo, Huabing Zhang, Wei Chen
Int. J. Biol. Sci. 2025; 21(7): 3144-3163. doi:10.7150/ijbs.107279
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N-acetylcysteine and raloxifene boost photodynamic therapy against cutaneous squamous cell carcinoma by decreasing TGFβ1 secreted by cancer-associated fibroblasts
María Gallego-Rentero, Luisa María Botella, Marta Mascaraque, Jimena Nicolás-Morala, Virginia Albiñana, Edgar Abarca-Lachen, Yolanda Gilaberte, Salvador González, Ángeles Juarranz, Elisa Carrasco
Int. J. Biol. Sci. 2025; 21(7): 3164-3182. doi:10.7150/ijbs.106642
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Integrated thermal proteome and thermal proximity co-aggregation profiling identifies ATP6V1C1 as a novel anti-cancer drug target
Shuang Zhang, Feng-Ming Li, Jun Wang, Yu Dong, Jing-Fang Luo, Xiao-Fang Huang, Yue Li, Guo-Yuan Zhu, Shi-Qian Qi, Han-Ming Shen, Qing Zhong, Chen Ming, Ke-Wu Zeng, Xiao-Jun Yao, Chris Soon Heng Tan, Jia-Hong Lu
Int. J. Biol. Sci. 2025; 21(7): 3197-3213. doi:10.7150/ijbs.106843
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Skeletal stem/progenitor cell-derived rather than osteoblast-derived IGF2 supports the development and homeostasis of skeletal system via STAT3
Tairan Wang, Kunao Zhu, Yi Tang, Yuxing Xia, Qian Zhang, Rong Cong, Chaoqun Pan, Feiwu Kang
Int. J. Biol. Sci. 2025; 21(7): 3229-3246. doi:10.7150/ijbs.112605
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Neferine Ameliorates Severe Acute Pancreatitis-Associated Intestinal Injury by Promoting NRF2-mediated Ferroptosis
Lilong Zhang, Kunpeng Wang, Wanrong Jiang, Pingan Ding, Weixing Wang, Kailiang Zhao, Chen Chen
Int. J. Biol. Sci. 2025; 21(7): 3247-3261. doi:10.7150/ijbs.112888
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SRGN-mediated reactivation of the YAP/CRISPLD2 axis promotes aggressiveness of hepatocellular carcinoma
Shuqiao Zhang, Hao Hu, Xinyu Li, Qiuxia Chen, Yilu Zheng, Huiting Peng, Zhuomao Mo, Wanting Hu, Yantao Li, Senkai Hong, Bijun Huang, Weihong Kuang, Shijun Zhang, Yang Cao
Int. J. Biol. Sci. 2025; 21(7): 3262-3285. doi:10.7150/ijbs.108151
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Microtubule dynamics is a therapeutic vulnerability in VHL-deficient renal cell carcinoma
Yue Pu, Ziruoyu Wang, Shishi Tao, Eun Ju Yang, Songlin Wu, Guowen Ren, Li-Jie Chen, Xiumei Zhang, Kaeling Tan, Yongjun Dang, Joong Sup Shim
Int. J. Biol. Sci. 2025; 21(7): 3286-3305. doi:10.7150/ijbs.109642
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RNF2 Modulates Lipid Metabolism and Inflammation in Alcohol-associated Liver Disease by Interacting with USP7
Qi Yan, Qi Fang, Zhiang Chen, Lijian Chen, Jian Du
Int. J. Biol. Sci. 2025; 21(7): 3306-3323. doi:10.7150/ijbs.111290
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Pterostilbene Induces Apoptosis in Awakening Quiescent Prostate Cancer Cells by Upregulating C/EBP-β-Mediated SOD2 Transcription
Zhichao Xi, Mengfan Liu, Xue Jiang, Jiling Feng, Rongchen Dai, Wan Najbah Nik Nabil, Xueyang Sun, Jiayi Chen, Hangui Ren, Juan Zhang, Qihan Dong, Man Yuan, Yang Li, Hongxi Xu
Int. J. Biol. Sci. 2025; 21(7): 3379-3396. doi:10.7150/ijbs.106219
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Luteolin improves precancerous conditions of the gastric mucosa by binding STAT3 and inhibiting LCN2 expression
Xinyu Hao, Shouli Yuan, Jing Ning, Yuanfei Zhou, Yanfei Lang, Xiurui Han, Qiao Meng, Ying Xiong, Rongli Cui, Yueqing Gong, Chao Ma, Weichao Xu, Yangang Wang, Xiaohuan Guo, Chu Wang, Jing Zhang, Weiwei Fu, Shigang Ding
Int. J. Biol. Sci. 2025; 21(7): 3397-3415. doi:10.7150/ijbs.111636
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Reviews

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Deciphering Scorpion Toxin-Induced Pain: Molecular Mechanisms and Ion Channel Dynamics
Dangui He, Yining Lei, Haixin Qin, Zhijian Cao, Hang Fai Kwok
Int. J. Biol. Sci. 2025; 21(7): 2921-2934. doi:10.7150/ijbs.109713
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Crosstalk between RNA-binding proteins and non-coding RNAs in tumors: molecular mechanisms, and clinical significance
Shiwen Cui, Qiu Peng, Qianfeng Ma, Xuemeng Xu, Wenlong Zhang, Xianjie Jiang, Shiming Tan, Wenjuan Yang, Yaqian Han, Linda Oyang, Shizhen Li, Jinguan Lin, Jiewen Wang, Longzheng Xia, Mingjing Peng, Nayiyuan Wu, Yanyan Tang, Qianjin Liao, Yujuan Zhou
Int. J. Biol. Sci. 2025; 21(7): 2991-3010. doi:10.7150/ijbs.109593
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Astrocytes Lingering at a Crossroads: Neuroprotection and Neurodegeneration in Neurocognitive Dysfunction
Xiaoxia Xu, Bin Mei, Yue Yang, Junxiong Li, Juntao Weng, Yueyue Yang, Qianyun Zhu, Honghai Zhang, Xuesheng Liu
Int. J. Biol. Sci. 2025; 21(7): 3122-3143. doi:10.7150/ijbs.109315
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Control of Snail1 protein stability by post-translational modifications: the basis for a complex regulation of Snail1 function
Antonio García de Herreros
Int. J. Biol. Sci. 2025; 21(7): 3183-3196. doi:10.7150/ijbs.108903
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Sepsis-associated encephalopathy: Mechanisms, Diagnosis, and Treatments update
Jin Li, Qi Jia, Lin Yang, You Wu, Yuliang Peng, Lixia Du, Zongping Fang, Xijing Zhang
Int. J. Biol. Sci. 2025; 21(7): 3214-3228. doi:10.7150/ijbs.102234
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Heart failure, inflammation and exercise
Qian Luo, Qing Zhang, Youli Kong, Shiqi Wang, Quan Wei
Int. J. Biol. Sci. 2025; 21(7): 3324-3350. doi:10.7150/ijbs.109917
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HSF1 Activation Mechanisms, Disease Roles, and Small Molecule Therapeutics
Bingwei Zhang, Yumei Fan, Ke Tan
Int. J. Biol. Sci. 2025; 21(7): 3351-3378. doi:10.7150/ijbs.110447
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